Index Vol. 16-23

The references of the Subject Index are given in the language of the respective contribution. Die Stichworte des Sachregisters sind in der jeweiligen Sprache der einzelnen Beitrage aufgeftihrt.

233

Les termes repris dans la Table des matieres sont donnes selon la langue dans laquelle l'ouvrage est ecrit.

A 17 Abortion, therapeutic 457,460 20 Academic research 169 18 Acanthocheilonema perstans 142 18 Acanthocheilonema streptocerca 142 22 Acaprin® (quinuronium sulfate) 42 20 Acebutolol 33, 36, 229 18 Acedapson (Hansolar®, 4',4"'-sulfonylbis­

acetanilide) 108, 156 17 Acedist® (bromfenofos, Ph 1882) 113, 134,

278 18 Aceperone 437 16 Acetacetat-Decarboxylase 414 17 2-Acetamido-5-nitrothiazole 261 17 Acetanilide 23, 497 20 Acetanilide 400 23 Acetanilide 212 20 Acetazolamide (Diamox®) 209,417 21 - 114 22 Acetohexamide (Dymelor®) 81 17 Acetohydroxamic acid 348 17 Acetone 13, 17 16 Acetophenone 260 17 2-Acetoxy-4' -chloro-3,5-diiodobenzanilide

(clioxanide) 114,135,164,277,281 17 a-Acetoxyheptanoic acid 416 17 7-Acetoxy-4-oxo-dodecanoic acid 416 16 4-Acetylaminobenzenesulfonamide 254 16 3-Acetylaminophenanthrene 259 16 2-Acetylamino-4-phenylthiazole 259 16 4-Acetylaminopropiophenone 254 22 Acetylaranotin 309 16 Acetylcholine 219,335,340 17 Acetylcholine 46 19 Acetylcholine 148 20 Acetylcholine 335, 410 20 Acetylcholine receptor 335 20 Acetylcholine receptor function 337 20 Acetylcholine receptor isolation 336 16 Acetylcholinesterase 219,336,370,410 20 Acetylcholinesterase 108, 324 16 Acetylcholinesterase activity 355 16 Acetylcholinesterases inhibitors 170 16 Acetyl Co-A-Carboxylase 420 20 N-Acetylcysteine 480 16 N-Acetylmuramyl-I-alanine amidase 328 22 N-Acetylneuraminic acid 307 20 Acetylsalicylic acid (Aspirin®) 400

23 Acetylsalicylic acid (Aspirin®) 114 16 O-Acetylserin-Sulfhydrylase A 390 17 Acetylstrophanthidin 35 22 Achromycin® (tetracycline) 53 19 Acidosis 529 18 Acid phosphotase 66 16 Aconitase-Isomerase 436 17 Aconitine 35,46 17 Acranil 119, 152 17 Acrichine® (quinacrine) 119 17 Acridine 295 16 Acriftavin 100 17 Acrolein 358 18 Acronine 440 21 Acrosin 366 21 Acrylamide 186 17 Actamer® (bithionol) 114,297 22 Actamer® (bithionol) 46 16 Actinomycin I 298 16 Actinomycin IV 298 16 Actinomycin V 298 17 Actinomycin C, (actinomycin D) 376 16 Actinomycin D (actinomycin C"

dactinomycin) 89, 118 17 - 273,302,376 20 - 467,474 21 - 199 22 - 132 23 - 38 22 Aculeacin A 131 21 Acute toxicity 212 23 N-Acyl-L-amino acid esters 141, 152 20 5'-O-Acyl-ara-cytidines 588 16 Acyl hydroxylation 231 17 I-Acyl-3-(2-thiocarbamoyl-5-

thiazolyl)urease 262 20 Adalat® (nifedipin) 407 22 Adamantane derivatives 277 19 Adenine 468 21 Adenocarcinoma 243 19 cyclic-Adenosine monophosphate

(adenosine 3',5'-monophosphate, cyclic­AMP) 511

20 - 272,329 23 - 43 16 Adenosin-Desaminase 408 16 Adenosintriphosphatase 412,414,438

234

17 Adenosinetriphosphatase 299 17 Adenosine triphosphate (ATP) 62 19 Adenosine triphosphate (ATP) 511 20 Adenosine triphosphate (ATP) 272 16 AdenosyJmethionin-Decarboxylase 396 19 Adenovirus 280 20 Adenylate cyclase 329 21 Adenylate cyclase 412,414 16 Adenylat-Kinase 390 19 Adenylcyclase 511,567 20 Adenylcyclase 274 16 Adenyl-Succinase 406 20 Adiphenine (Trasentineill» 420 20 Adrenaline 410,418 20 a-Adrenergic blockers 199 19 p-Adrenergic blockers 361 20 p-Adrenergic blockers 222 20 p-Adrenergic receptor 340 16 Adrenocortical microsomes 262 17 Adriamycin 374 18 Adriamycin 441 20 Adriamycin 467, 474 22 Adriamycin 67 18 Adriamycinone 441 18 Aedes aegypti 284 18 Aedes polynesiensis 264 17 A elurostrongylus abstrusus 178 21 AF 1890 [1-(2,4-dichlorobenzyl)-indazole-

3-carboxylic acid] 354 21 AF 1312/TS (I-p-chlorobenzyl-IH-

indazole-3-carboxylic acid) 353 20 Affinity constants 136 20 African trypanosomiasis 445 22 Afridol violet 38 16 Ag-Ab (Antigen-antibody complex) liS 19 Agglutination test 179,556 23 Agglutination test 17 20 Agglutinin 328 23 Agglutinin 16 23 Agglutinogens 21 23 AIPF (anaphylactoid inflammation

promoting factor) 38 16 Alanyl-tRNA-Synthetase 400 17 Alazopeptin 324 22 Albegoill> (camazepam) 242 22 Albucidill> (sulfacetamide) 31 17 Alcohol 94 17 Alcoparill> (bephenium

hydroxynaphthoate) 130 20 Alcoparill> (bephenium

hydroxynaphthoate) 451 22 Alcoparlll> (bephenium

hydroxynaphthoate) 47 22 Aldactoneill> (spironolactone) 76 16 Aldehyde dehydrogenase 246,442 20 Alderinill> (pronethalol) 411 22 Aldocorteneill> (aldosterone) 76 16 Aldolase A 402 16 Aldolase B 402 20 Aldometill> (a-methyldopa) 411 17 Aldophosphamide 357

Index Vol. 16-23

20 Aldophosphamide 468 16 Aldose-Reductase 390 22 Aldosterone (Aldocorteneill» 68, 76 20 Aldosterone antagonists 213 16 Alfalfa Mosaikvirus 384 16 ALG (Antilymphocyte globulin) 102, 123 18 Alkaloids 409 22 Alkeranill> (melphalan) 63 16 Alkohol-Dehydrogenase 388,392,400 23 Alkylammonium compounds 120 17 2-Alkyl-I,2,3,3a,4,5-

hexahydroimidazo[l,5-a]quinolines 254 16 N-(3-Alkyl-5-nitro-4-thiazolin-2-

ylidene)amides 19,20 22 N-Alkylnorpethidines 169 23 N-Alkylpiperidines 171 23 4-Alkylpyridines 103 23 N-Alkylpyridinium compounds 171 23 N-n-Alkyltritylamines 122 23 Allamandin 83 16 Allanosine 90 17 Allantoin 340 20 Allercurill> (clemizole) 426 20 Allergen 589 18 Allergic reaction 255 20 Allergic rhinitis 589 18 Allobarbital 453 19 Allobarbitone 210,225 17 Allopurinol (Zyloprimill» 340 20 - 402 17 Allylthiourea (thiosinamine) 274 22 Alpenill> (ampicillin) 50 22 Alphaprodine (Nisentilill» 172 22 Alprazolam 254, 255 16 Alprenolol 355 20 Alprenolol 33, 36, 226, 229, 230 20 p-Alprenolol 227 16 ALS (Antilymphocyte serum) 101 22 Altafurlll> (furaltadone) 45 19 Aluminium hydroxide 613,618 23 Aluminium hydroxide IS 19 Aluminium phosphate 265 20 Alupentill> (orciprenaline) 419 16 Amantadine (Symmetrelill» 347 20 - 423 22 - 62.277 16 Ambilharlll> (niridazole) 14 20 Ambilharill> (niridazole) 448 22 Ambilharill> (niridazole) 47 17 Amebarsinill> (diphetarsone) 123 18 Amebic disease, pathogenesis 225 22 Amenoroneill> (ethisterone) 73 20 American trypanosomiasis (Chagas

Disease) 446 22 Amethopterinill> (methotrexate) 64 16 w -Amidase 388 22 Amidines 299 17 Amidostomum anseris 171 20 Amidoximes 214 22 Amikacin (Amikinill>, Biklinill» 57 22 Amikinill> (amikacin) 57

Index Vol. 16-23

20 Amiloride (Midamor®) 213,417 17 Amino acids 82 22 Amino acids 308 16 4-Aminobenzenesulfonamide

(sulfanilamide) 259 19 p-Aminobenzoic acid 286 21 p-Aminobenzoic acid 191 17 6-Amino-2,4-bis(trichloromethyl)-1,3-

benzodioxan 286 16 y-Aminobutyric acid 221,222,290,339,

348 20 y-Aminobutyric acid receptor 341 16 e-Aminocaproic acid 88, 118 16 l-Aminocyclopentane carboxylic acid

(cycloleucine) 88 22 6-Amino-6-deoxy-o-glucose 307 17 4-Amino-4-deoxypteroic acid 325 22 5'-Amino-2',5'-dideoxy-5-iodouridine 296 17 2-Amino-5-( diethylamino )phenol 260 17 2-Amino-4,7-dimethoxy-6-

thiocyanatobenzothiazole 272 22 Aminoglutethimide (Elipten®) 77 22 2-Amino-4-hydroxypyrimidines 276 17 5-Aminoimidazole-4-carboxamide 336,

338 16 b-Aminolaevulinsllure-Dehydratase 440 18 2-Amino-5-( l-methyl-5-nitro-2-imid­

azolyl)-1,3,4-thiadiazole 327 17 4-Amino-2-methyl-N-(5-nitro-2-thiazolyl)-

5-pyrimidinecarboxamide 262 17 2-Aminomethyltetrahydroquinolines 252 21 6-Aminonicotinamide 199 17 trans-5-Amino-3-[2-(5-nitro-2-furyl)vinyl]-

1,2,4-oxadiazole (SQ 18506) 267 17 6-Amino-N-(5-nitro-2-thiazolyl)-m-

toluamide 263 16 Aminopeptidase 414 20 Aminophenazone (Pyramidon®) 401 17 N-(p-Aminophenyl)-N',N'-

dimethylacetamidine 309 16 Aminopterin 93, 118 17 Aminopterin 324 18 Aminopterin 107 20 Aminopterin 471 22 6-Aminopyrazolo[4,3-c]pyridin-4(5H)-

one 289 17 4-Aminopyrazolo[3,4-d]pyrimidine 343 17 7-Aminopyrazolo[4,3-d]pyrimidine 343 23 1-(3-Amino-4-pyridyl)-4-aryl-

piperazines 213 17 Aminopyrine 490 17 4-Aminopyrrolo[2,3-d]pyrimidine 344 18 4-Aminoquinolines 101, 104 18 p-Aminosalicylic acid (PAS) 212 22 p-Aminosalicylic acid (PAS) 34 16 d-Aminosllure-Oxidase 396 16 I-Aminosllure-Oxidase 400 21 Aminosidine 129, 179 21 Aminotetralin derivatives 429 17 5-Amino-v-triazole-4-carboxamide 336 22 4-Aminotwistanes 280

18 Amiperone 437 20 Amiphenazole (Daptazole®) 397 20 Amitriptyline (Elavil®, Laroxyl®) 394 16 Amitryptilinemethyliodate 352

235

18 Amodiaquine (Camoquin®) 102, 103, 143 20 - 435 22 - 42 18 Amoebiasis 78,225,278,355 19 Amoebiasis 570 20 Amoebiasis 438 18 Amoebiasis, exfoliative 82 18 Amoebiasis, surgical problems 79 18 Amoebicidal drugs, evaluation 353 20 Amoebicides 438 18 Amoeboma 83 17 Amoebotaenia sphenoides 299 18 Amopyroquine (Propoquin®) 102 22 Amoxicillin (Amoxil®) 50 22 Amoxil® (amoxicillin) 50 20 cyclic-AMP (cyclic adenosine 3',5'­

monophosphate) 272,329,580,585 21 - 414 16 AMP (adenosin monophosphat)

desaminase 410 16 AMP Nucleosidase 398 16 Amphetamine (Benzedrine®) 217,341,346 20 - 397,418 22 Amphetamine derivatives 363 16 d-Amphetamine 347 16 I-Amphetamine 347 18 Amphotericin B 290, 320 20 Amphotericin B 441,443,444 22 Amphotericin B 59, 97, 103, 132 16 Ampicillin (Alpen®, Penbritin®,

Polycillin®) 313 19 - 539 22 - 50 20 Amplivix® (benziodarone) 407 20 Amprotropine (Syntropan®) 420 16 a-Amylase 388 16 p-Amylase 406 20 Amylene hydrate 387 22 Amylobarbitone 360 16 iso-Amylphenylketone 262 22 Anadrol® (oxymetholone) 69 17 Anaemia, haemolytic 64 20 Anaesthetics 386 22 Analgesic antagonists 150 22 Analgesics 150 23 Anaphylactoid inflammation promoting

factor (AIPF) 38 20 Anaphylaxis 589 22 Anavar® (oxandrolone) 70 17 Ancaris® (thenium) 130 22 Ancef® (cefazolin) 53 22 Ancobon® (flucytosine) 36 17 Ancylol® (disophenol) 131 17 Ancylostoma braziliensis 163,184 18 Ancylostoma braziliensis 199 17 Ancylostoma caninum 160 18 Ancylostoma caninum 199

236

19 Ancylostoma ceylanicum 64 16 Ancylostoma duodenale 163, 165 17 Ancylostoma duodenale 160, 161 18 Ancylostoma duodenale 198 19 Ancylostoma duodenale 8,17,25,36,46,64,

70,81,86,90,96, 161, 173 20 Ancylostoma duodenale 453 17 Ancylostoma tubaeforme 163 19 Ancylostomiasis 2, 141 16 ANDA (Abbreviated New Drug

Application) 201 22 Androcur® (cyproterone acetate) 70 17 Androsterone 24 20 Anectine® (suxamethonium) 422 17 Anelmid® (dithiazanine) 127 20 Anergy 361 20 Angina pectoris 36 20 Angioedema 589 18 Angiostrongylosis 196 18 A ngiostrongylus cantonensis 195 18 Angiostrongylus vasorum 196 20 Angiotensin 245 18 Angolamycin 422 23 Anguidin 81 17 Anhydro-7-chlorotetracycline 232 22 Anileridine 169 17 Aniline 17 20 Aniline lost glucuronioe 563 17 Ankilostin® (tetrachlorethylene) 130 22 Anodynin 200 18 Anopheles balbacensis 249 18 Anopheles culicifacies 248 18 Anophelesfunestus 174 18 Anopheles gambiae 174,283 18 Anopheles minimus 101 18 Anopheles philippinensis 248 18 Anopheles stephensi 248 17 Anoplocephala magna 154 22 Anspor® (cephradine) 53 17 Antabuse 360 20 Antazoline (Antistin®) 426 20 Antepar® (piperazine) 451 20 Antergan® (phenbenzamine) 424 16 Anthelmintic activity 168 16 Anthelmintic agents 158 18 Anthelmintic agents 192, 198 17 Anthelmintic agents 110 19 Anthelmintic agents 147, 166 20 Anthelmintic agents 348 19 Anthelmintic agents, screening 48, 55 19 Anthelmintic drugs toxicity 172 17 Anthiolimine (Anthiomaline®) 112, 183 17 Anthiomaline® (anthiolimine) 112,183 22 Anthiphen® (dichlorophene) 46 23 Anthralin 67 16 Anthranilat-Synthetasekomplex 410,436 17 Antiarrhythmic drugs 36 17 Antiarrhythmic drugs, classification 51 17 Antiarrhythmic drugs,

mechanism of action 45 17 Antiarrhythmic effect 36

Index Vol. 16-23

16 Antibacterial action 51 23 Antibacterial activity 217 21 Antibacterial agents 11 22 Antibakterielle Chemotherapie 328 18 Antibiotics 415 19 Antibiotics 186, 450 23 Antibiotics 51 19 Antibiotics tests 574, 598 22 Antibiotika 328 22 Antibiotika, bakterielle Resistenz 334 22 Antibiotika, Beurteilungsgrundlagen 337 22 Antibiotika, Bewertung 327 22 Antibiotika, Bioverfiigbarkeit 339 22 Antibiotika, Dosierung 344 22 Antibiotika, Entwicklung 328 22 Antibiotika, Halbwertzeit 343 22 Antibiotika, Konzentration 343 22 Antibiotika, Mikrobiologie 337 22 Antibiotika, Nebenwirkungen 350 22 Antibiotika, Pharmakokinetik 338 22 Antibiotika, Resistenztypen 336 22 Antibiotika, Wechselwirkungen 352 20 Antibody 14 23 Antibody 13 19 Antibody titres 542 23 Anticancer activity 218 17 Anticancer agents 322 20 Anticancer agents 467 20 Anticancer agents, activation 555 17 Anticancer agents, metabolism 386,387 20 Anticancer agents, toxicity 479 19 Anticholera immune serum 547,551 19 Anticholera immunization 482 19 Anticholera vaccine 584 16 Anticholinergic drugs 342 20 Anticholinergic drugs 420 20 Anticholinergic esters 124 19 Anticholinesterase effect 329 20 Anticoagulants 404 20 Anti-epileptic drugs 424 23 Antifungal activity 211 22 Antifungal agents 93 22 Antifungal agents, drug combinations 132 16 Antigen 70, 72 19 Antigen 180,279,471,475 20 Antigen 14 23 Antigen 13 19 Antigen electrophoresis 122 19 Antigen fractionation 119 19 Antigen purification 125, 128, 131,280 16 Antigen-antibody complex (Ag-Ab) 115 16 Antigen reactive cells (ARC) 70 20 Antihistamines 424 23 Antihistaminic activity 220 20 Anti-humanthymocyte globulin 581 20 Antihyperlipidaemic agents 417 23 Antihypertensive activity 216 20 Antihypertensive agents 198,236,407 20 Antihypertensive chemotherapy 199 20 Antihypertensive combinations drugs 246 23 Anti-inflammatory activity 215

Index Vol. 16-23

17 Antiinflammatory agent 470 18 Anti-leishmanial agents 332 18 Antileprotic agent 159 16 Antilymphocyte globulin (ALG) 102, 123 16 Antilymphocyte serum (ALS) 101 20 Antilymphocyte serum (ALS) 581 23 Antimalarial activity 210 18 Antimalarial drugs 101 20 Antimetabolites, anticancer activity 470 16 Antimicrobial activity 315 20 Antiminth® (pyrantel pamoate) 451 18 Antimonic acid 306 17 Antimony dimercaptosuccinate (Astiban®,

stibocaptate, TWSb/6) 112, 140, 143, 182 17 Antimony sodium gluconate

(Triostam®) Ill, 140 17 Antimony sodium tartrate (Stibunal®,

Emeto-Na®) Ill, 140, 183 17 Antimosan® (stibophen) 112 16 Antineoplastic agents 88 16 Antiproliferative agents 75 16 Antiproliferative drug 86 21 Antipsychotic drugs 412 20 Antipyretics 400 20 Antipyrine (phenazone) 401 16 Antischistosomal drug 14 18 Antischistosomal drug 16 16 Antistaphylococcal drugs 320 20 Antistin® (antazoline) 426 19 Antitetanus immunoglobulin 398 19 Antitetanus serum 210,289,330,362,375,

381,393 20 Anti-thymocyte gammaglobulin 583 16 Antithymocyte globulin (ATG) 74, 124 16 Antithymocyte serum (ATS) 74 19 Antitoxin 324 19 Antitoxin titers 609 18 Antituberculous drugs 213 16 Antitumor action 51 18 Antitumor agents 23 23 Antitumor agents 65 23 Antitumor agents 65 17 Antiverm® (phenothiazine) 131 22 Antiviral agents 267 20 Antrenyl® (oxyphenonium bromide) 420 22 Antrycide® (quinapyramine) 42 17 Antrypol® (suramin sodium) 132 20 - 445 20 Anturan® (sulfinpyrazone) 401 19 Anuria 508 20 Anxiety 38 17 Aphesal 297 22 Aphidicolin 312 16 Apoferritin 380 16 Apomorphine 342 21 Apomorphine 411 21 Apomorphine analogs 425 18 Appendicitis, amoebic 84 20 Apresoline® (hydralazine) 408 20 Apronalide (Sedormid®) 387

17 Ara-A (9-P-o­arabinofuranosyladenine 345

20 Ara-A (9-p-o­arabinofuranosyladenine 478

22 Ara-A (9-P-o­arabinofuranosyladenine 292

17 9-p-o-Arabinofuranosyladenine (ara-A) 345

20 9-p-o-Arabinofuranosyladenine (ara-A) 478

22 9-p-o-Arabinofuranosyladenine (ara-A) 292

17 I-p-o-Arabinofuranosylcytosine (ara-C) 332,341

20 I-p-o-Arabinofuranosylcytosine (ara-C) 472

22 I-p-o-Arabinofuranosylcytosine (ara-C) 293

17 I-p-o-Arabinofuranosylcytosine,5'­adamantoate 335

22 I-p-D-Arabinofuranosylthymine (Ara-T) 294

16 L-Arabinose-Isomerase 414 17 ara-C (l-p-o­

arabinofuranosylcytosine) 332,341 20 ara-C (l-p-o­

arabinofuranosylcytosine) 472 22 ara-C (l-p-o-

arabinofuranosylcytosine) 293 17 Arachidonic acid 430 16 Arachin 380 20 ara-Cytidine 584 22 Aralen® (chloroquine) 42 22 Aranotin 309 22 Ara-T (l-p-o-

arabinofuranosylthymine) 294 16 ARC (antigen reactive cells) 70 16 ARC, stimulation of 75 17 Arecoline 121 20 Afronad® (trimetaphan camsylate) 409 16 Arginase 398,436 18 Arginine 426 16 Arginin-Decarboxylase 418 16 Arginin-Succinase 406 22 Aristocort® (triamcinolone) 75 17 Arrhythmia 34 17 Arsenamide (thiacetarsamide,

Caparside®, Caparsolate®) 122, 181 20 Arsobal® (melarsoprol, Mel B®) 445 22 Arsobal® (melarsoprol, Mel B®) 40 18 Arsphenamine (Salvarsan®) 331 22 - 37 17 Arthrobacter colchovorum 382 18 Arthropod-borne disease 45 16 Arylamidase 408 16 Arylaminedecarboxylase 336 20 Arylbutenes 111 22 3-Arylpiperidines 187 20 Arylpropenes III 20 Arylpyrrolidines 71

237

238

16 Arylsulfatase A 396 17 Arylthiohydantoins 290 22 Anneimittelinteraktionen 352 22 Arzneimittel, klinische

Untersuchungen 329 17 Ascariasis 155 18 Ascariasis 192 19 Ascariasis 15,30, 141, 167 20 Ascariasis 451 20 Ascaris 355 18 Ascaris cuticulum 192 19 A scaris infection 30 16 Ascaris lumbricoides 163, 165,293 17 Ascaris lumbricoides 157 18 Ascaris lumbricoides 191 19 Ascaris lumbricoides 17,29,30,81, 161 16 Ascaris suis (suum) 167 17 Ascaris suis (suum) 155 17 Ascarotrat® (tetramisole) 125 23 Ascites cell 141 16 Ascorbic acid (vitamin C) 284 17 Ascorbic acid (vitamin C) 490 22 Ascorbic acid (vitamin C) 84, 85 23 Ascorbic acid (vitamin C) 51 20 Asian liver fluke disease 450 22 Asparaginase (Crasnitin®) 67 16 L-Asparaginase 110, 128,400,436 20 L-Asparaginase 476 16 Aspartase 404,438 16 Aspartat-Aminotransferase 394, 396,436 16 Aspartat-p-Decarboxylase 418 16 Aspartat-Kinase 398 16 Aspartat-Kinase-I-Homoserin-I-

Dehydrogenase 414 16 Aspartat-Transcarbamylase 412 23 Aspergillus niger 211 16 Aspergillus sclerotiorum 31,37, 57 17 Aspergillus sclerotiorum 245 18 Aspergillus sclerotiorum 16 19 Asphyxia 320 17 Aspidin (polystichin) 120, 148 16 Aspirin® (acetylsalicylic acid) 98 17 Aspirin® (acetylsalicylic acid) 433,470 19 Aspirin® (acetylsalicylic acid) 253 20 Aspirin® (acetylsalicylic acid) 400 21 Aspirin® (acetylsalicylic acid) 199 17 Asthma 462 20 Asthma 589 21 Asthma 243 17 Astiban® (stibocaptate) 112 22 Astiban® (stibocaptate) 47 17 Asuntol® (coumaphos) 129 17 Atabrine® (quinacrine) 119 20 Atarax® (hydroxyzine) 392 17 Atebrin® (mepacrine, quinacrine) 294 20 Atebrin® (mepacrine, quinacrine) 441 22 Atebrin® (mepacrine, quinacrine) 38 20 Atenolol (Tenormin®) 34,36,237,411 16 ATG (Antithymocyte globulin) 74,124 17 Atherosclerosis 39 22 Ativan® (lorazepam) 242

Index Vol. 16-23

17 Atmungsferment 496 20 Atopy 589 22 Atoxyl® (sodium arsanilate) 40 17 ATP (adenosine triphosphate) 62 19 ATP (adenosine triphosphate) 511 20 ATP (adenosine triphosphate) 272 17 ATPase 63 16 ATP-Sulfurylase 414 17 Atrioventricular node 44 20 Atromid-S (clofibrate) 418 16 Atropine 217,341 20 Atropine 335 16 Atropinmethylnitrate 352 16 ATS (antithymocyte serum) 74 22 Aureomycin® (chlorotetracycline) 53 19 Autonomic dysfunction 245 20 Auxins 112 19 Auxotrophic mutants 467 16 Avidin 376 17 A vitellina centripunctata 294 17 A vitellina woodlandi 294 22 Avlosulfone® (dapsone) 33 17 8-Azaadenine 336 18 Azacrine dihydrochloride 146 16 5-Azacytidine 96 17 5-Azacytidine 326 20 5-Azacytidine 471 17 6-Azacytidylic acid 328 17 6-Azacytosine 328 16 8-Azaguanine 94 17 8-Azaguanine 335 17 8-Azaguanosine 336 17 8-Azaguanylic acid 335 17 2-Azahypoxanthine 370 17 8-Azahypoxanthine 336 17 8-Azainosine 336 17 8-Azainosinic acid 336 20 Azamethonium bromide

(Pendiomid®) 201,409 17 5-Azaorotic acid 326 17 5-Azaorotidylic acid 326 18 Azaperone 437 22 Azaribine (Triazure®) 64 16 Azaserine 88 17 Azaserine 323 20 Azaserine 470 16 Azathioprine (Imuran®) 88, 92, 94, 103,

119 17 - 341 20 - 583,584 17 5-Azauracil 326 16 6-Azauracil 96 17 6-Azauracil 327 17 5-Azauridine 326 16 6-Azauridine 98, 123 17 6-Azauridine 327 17 5-Azauridylic acid 326 17 6-Azauridylic acid 327 17 8-Azaxanthine 335 22 Azidocodeine 156 22 Azidomorphine 156

Index Vol. 16-23

16 Azoferredoxin 376 22 Azomycin 45 17 4-Azo-l-naphthylamines 258 21 Azathioprine 351 17 Azotomycin 324

B 17 Bacillus subtilis 370 18 Bacillus subtilis 21 16 Bacitracin 314 22 Bacitracin 59 20 Baclofen (Lioresalill) 423 21 Bacterial agents 176 20 Bacterial infections 355 21 Bacteriostatic agents 167 16 Bacterium subtilis 51 22 Bactocillill (oxacillin) 50 19 Bactonutrient broth 466 22 Bactrimill

(sulfamethoxazole + thrimethoprim) 33 22 Bakterielle Infektionen 328 20 BAL (dimercaptol) 446 20 Balantidiasis 441 20 Balantidium coli 441 17 Banancrisill (thenium) 130 17 Banminthill (pyrantel) 124 22 Banminthill (pyrantel) 48 17 Banminth II (morantel) 124 20 Bamethan (Vasculatill) 411 17 Banocideill (diethylcarbamazine) 127 20 Banocideill (diethylcarbamazine) 455 20 Banthineill (methantelium bromide) 420 17 Barbiturates 76 18 Barbiturates 432 19 Barbiturates 324 22 Barbiturates 366 17 Bathocuproine 14 20 Bayer 2502 (Lampitill) 446 17 Bayer 4059 (brotianide) 284 17 Bayer 9015 (menichlopholan,

Bilevon-MiIl) 278 17 Baytexill (fenthion) 128 16 BCND [bis(chlorethyl)nitrosourea] 86 16 Bean leaves 281 22 Beconaseill (beclomethasone 17,21-

dipropionate) 74 22 Beclomethasone 17,21-dipropionate

(Propadermill, Beconaseill) 74 17 Befeniol® (bephenium

hydroxynaphthoate) 130 17 Bemarsalill (diphetarsone) 123 20 Bemegride (Megimideill) 397 22 Bemidome 171 20 Benactyzine (Suavitilill) 392 20 Benadryli1l (diphenhydramine) 424 20 Bendroflumethiazide (Naturetin®) 417 20 Benemidill (probenecid) 402 18 Benperidol 437 19 Bentonite 75 19 Bentonite flocculation test 76 19 Bentonite suspension 76

21 Bentropine 412 22 Benzalkonium chloride (Zephiran

chlorideill) 29 19 Benzathine penicillin 246 20 Benzedrexill (propylhexedrine) 419 20 Benzedrineill (amphetamine) 397,418 17 Benziform® (carbon tetrachloride) 116 23 Benzilonium n-alkylsulfonates 118 16 Benzimidazoles 159 22 Benzimidazoles 108,281 20 Benziodarone (Amplivixill) 407 22 Benzitramid 195 16 Benzoazolureas 95 20 Benzoctamine (Tacitine®) 393 22 - 362 21 Benzo[6,7]cyclohepta[I,2,3-

de]pyrido[2,I-a]isoquinolines 447 22 Benzodiazepine story 229 22 1,4-Benzodiazepin-2-one 4-oxides 241 17 7,8-Benzoflavone 16 16 Benzofuroxan 95 22 4,5-Benzo[hept-l,2,6-oxdiazines] 232 16 Benzoic acid 260 17 Benzoins 300 23 Benzomorphan 203 22 6,7-Benzomorphans 159 20 Benzomorphan derivatives 110 21 Benzophenone 191 23 Benzophenone 110 23 2H-l,2,4-Benzothiadiazine-l,l­

dioxides 216 16 Benzothiopyrano-[4,3,2-cd]indazoles 40 17 2H-[1]Benzothiopyrano[4,3,2-

cd]indazoles 249 17 Benzphetamine 18 17 3,4-Benzpyrene 494,497 17 Benzpyrene-hydroxylase 495 16 Benzthiazoles 95 23 Benzyldimethylalkylammonium

compounds 185 17 2-Benzylidene-4-cyclopentene-l ,3-

dione 309 16 Benzylmethylketone 262 22 I-Benzylnorpethidine 168 23 Benzyloxyarylacetic acid 220 16 Benzylpropylketone 262 16 Bephenium (Alcopar®, Befeniol®,

Frantin®, Naftamonill) 158, 170 17 - 130, 158, 161, 168, 171, 175

239

19 - 33,36,40,70,73,86,90,92,103,150,166 20 - 451 22 - 47 18 Berberine 290,326 19 Berberine 510,519,520 20 Berberine 444 19 Berberine sulphate 520 20 Berberine sulphate 444 22 Berenil® (diminazene) 42,45 23 Betacoccus arabinosacerus 30 19 Betamethasone (Betnelan®,

Celestoneill) 374, 380

240

20 Betamethasone (Betnelan®, Celestone®) 446,456

22 - 74 22 Betamethasone 17-valerate (Betneval®) 74 20 Bethanidine (Esbatal®) 215,410 21 - 357 22 Betnelan® (betamethasone) 74 22 Betneval® (betamethasone 17-valerate) 74 18 BHC (l,2,3,4,5,6-hexachlorocyclo-

hexane) 248,267 16 Bicillin 319 16 Bicuculline 222 18 Bikaverin 323 22 Biklin® (amikacin) 57 22 Bilarcil® (metrifonate) 47 23 Bile salts 118 17 Bilevon® (hexachlorophene) 114 17 Bilevon-M® (Bayer 9015,

menichlopholan) 278 18 Bilharsiasis 15,200 23 Bilinear model 168 17 Bilirubin 489 17 Bilirubin synthesis 489 17 Bindschedler's Green 260 20 Biochemical blockade 15 22 Biochemical pharmacology II 20 Biochemistry 17 20 Bioisoterism 12 20 Biological activity 12 23 Biological activity 98, 148,200 20 Biological cell systems 262 16 Biological evaluation 199 17 Biological membrane 88 21 Biological response 117 21 Biological response quantification 107 20 Biological stereoselectivity 104 20 Biological transport mechanism II 20 Biomembrane 263 20 Biomembrane processes 275 21 Biophase 108 18 Biopterin 299 20 Bioreceptors 14 20 Biosynthesis 13 19 Biotin (vitamin H) 286 22 Biotin (vitamin H) 86 16 Biotincarboxylase 436 23 Biphenyl 110 17 2,2'-Bipyridine 14,18 21 Birnberg bow 329 17 2,2' -Bis-(p-acetamidophenoxy)ethyl ether

(diamfenethide, diamphenethide, Coriban ®) 118, 137, 286

17 2,4-Bis( 4-arylpiperazino )-3-pentanones 252

21 N,N'-Bis(dichloroacetyl)-1,8-octanediamine (WIN 18446) 352

16 Bis(chlorethyl)nitrosourea (BCNU) 86 17 1,3-Bis(2-chloroethyl)-I-nitrosourea 367 17 Biscomate® (bitoscanate) 131 17 Bishydroxycoumarin 25 17 Bis(2-hydroxy-3-nitro-5-

chlorophenyl)sulphide 280

Index Vol. 16-23

17 1,5-Bis(p-methylaminophenoxy)-pentane dihydrochloride 286

17 Bithin® (bithionol) 114 17 Bithionol [Actamer®, Bithin®, Bitin®, 2,2'­

thiobis(4,6-dichlorophenol)] 114, 148, 149, 152, 153, 154,278,297

20 - 447,451 22 - 46 17 Bithionol sulfoxide (Bitin-S) 114, 134, 149,

150,278,297 17 Bitin® (bithionol) 114 20 Bitin® (bithionol) 447 17 Bitin-S (bithionol sulfoxide; 2,2'­

sulphinyl(4,6-dichlorophenol) 114,278, 297

16 Bitoscanate (Biscomate®, Jonit®, 1,4-phenylenediisothiocyanate, phenylene thiocyanate) 158, 171

17 - 131, 158, 163 19 - 2,6,23,52,60,64,70,71,81,86,90,

91,96, 166 22 - 49 17 Bitriben® (hexachloroparaxylol) 117 22 Blenoxane® (bleomycin) 67 20 Bleomycin (Blenoxane®) 474 22 Bleomycin (Blenoxane®) 67 17 Bleomycin A 379 17 Bleomycin B 379 20 Blockadren® (timolol) 36 20 P-Blocking agents 28 20 P-Blocking agents, contraindications 38 20 P-Blocking agents, investigation 29 20 P-Blocking agents, pharmacology 31 20 P-Blocking agents, side actions 39 19 Blood examination 129 20 Blood glucose concentration 548 23 BOL-148 (2-bromo-d-Iysergic acid

diethylamide) 40 22 Bonaid® (buquinolate) 34 23 Bondapak C-18® 125 22 Bonaphthone 278,301 19 Bordetella bronchiseptica 181,260 19 Bordetella para pertussis 181,257 19 Bordetella pertussis 178, 257, 348 23 Bordetella pertussis 12, 15,45 19 Bordetella pertussis serotypes 260, 348 20 Bovine pleuropneumonia 355 16 Bovine serum albumin (BSA) 107 19 Bowel 473 16 Brain 212,282,354 19 Brain tissue 302 20 Brethine® (terbutalin) 419 21 Brethylium 357 20 Brinaldix® (clopamide) 417 16 BRL 1288 (2-[Ethyl-n-propylamino]ethyl-

a,a-diphenylglycolate HCI) 342 22 Bromazepam (Lexotanil®) 250, 262 16 Bromegrass Mosaikvirus 382 21 17 P -Bromoacetoxy-19-nortestosterone 336 16 Bromfenofos (bromofenfos, Acedist®,

Ph 1882) 168

Index Vol. 16-23

17 Bromfenofos (bromofenfos, Acedistill, Ph 1882) 113, 134, 168,278

21 16a-Bromoacetoxyprogesterone 336 22 5-Bromodeoxycytidine 296 21 2-Bromo-a-ergocryptine 432 22 5-Bromo-2'-deoxyuridine 295 23 2-Bromo-d-lysergic acid diethylamide (Bol-

148) 40 17 4'-Bromo-y-resorcylanilide (resorantel,

Terenol®) 284, 298 17 Brotianide (3,4'-dibromo-5-

chlorothiosalicylanilide acetate, Bayer 4059,I>irian®) 115,136,284

17 Broxolin® (glycobiarsol) 123 20 Brucella abortus 356 18 Brucellosis 279 19 Brucellosis 280 20 Brufen® (ibuprofen) 402 17 Brugia malayi 180 18 Brugia malayi 142, 174,201 20 Brugia malayi 455 18 Brugiapahangi 151 16 BSA (Bovine serum albumin) 107 17 Buban® (bunamidine) 121,302 19 Bubonic plague 347 22 Buclosamide 129 18 Bufalin 431 20 Bufetolol 226 22 Buformin (Silubin®) 80 19 Bulbar Tetanus 220 16 Bulbocapnine 346 20 Bumetanide (Burinex®) 211,417 17 Bunamidine (Buban®, Scolaban®) 121,

148, 149, 152, 154, 155,302 20 a-Bungarotoxin 335,339 20 Bunitrolol 227 20 Bunolol 34, 36, 228 20 Bupicomide 241 20 Bupranolol 226 20 Buprenorphine (Temgesic®) 55 22 - 156,157,211 22 Buquinolate (Bonaid®) 34 20 Burirnnamide 427 20 Burinex® (bumetanide) 417 16 Bushy stunt-Virus 384 16 Busulfan (Myleran®) 86 17 - 337,365 20 - 469 22 - 64 21 Butaclamol 415,417 17 Butanol 74 20 Butazolidine® (phenylbutazone) 401 20 Butidrine 32 18 Butirosin A 422 18 Butirosin B 422 20 Butorphanol 62, 89 22 Butorphanol 163 20 Butoxamine 28, 32, 227 18 Butropipazone 437 17 4-Butylaminobenzofg)quinoline 295 20 Butydrin 225

16 2-n-Butyloctadecanoic acid 236 16 2-n-Butyltetradecanoic acid 236 16 y-Butyrobetaine 290 16 y-Butyrolactone 348 16 Butyrophenone 262 21 Butyrophenone 411 21 Butyrophenone derivatives 449 20 Butyrylcholinesterase 108 17 Butyrylperazine 75 17 B.W.65-54[DL-erythro-a-(3,4-

dichlorophenyl)-p -(t-butylamino)­propanol HCI) 25

17 Bymix® (coumaphos) 129

C 21 Cadmium 353 19 Caffeine 521 20 Caffeine 396 22 Caffeine 367 23 Caffeine 114 22 Calcitonin 77 16 Calcium 338 17 Calcium arsenate 293 22 Calcium elenolate 306 22 Camazepam (Albego®) 242 16 Cambendazole 159, 160

241

17 Cambendazole 126, 157, 163, 167, 169, 177 18 Camolar® (cycloguanil pamoate, CI-

501) 107, 156 20 Camolar® (cycloguanil pamoate, CI-

501) 435 22 Camolar® (cycloguanil pamoate, CI-

501) 44 18 Camoquin® (amodiaquine) 102, 143 22 Camoquin® (amodiaquine) 42 22 Camptothecin 313 22 Canaline 308 20 Cancer 36, 362, 364, 466 20 Cancercell 482,532 20 Cancer cell glycolysis 548 20 Cancer chemotherapy 465 20 Cancer combination chemotherapy 484 20 Cancer multistep therapy (CMT) 536 20 Cancer therapy 532 20 Cancer tissue capillaries 553 20 Cancer tissue overacidification 550, 553,

563 20 Cancerostatica effects 524 20 Cancerostatica molecular weight 543 20 Cancerostatica concentration 544 20 Cancerostatica side effects 524 20 Cancerostatic drugs 523, 533, 551 20 Cancerostatic drugs, combinations 532 20 Cancerostatic drugs, action 523 20 Cancerostatic drugs, cycle phase

specificity 527 20 Cancerostatic drugs, dosage 535 20 Cancerostatic drugs, effective dose 547 20 Cancerostatic drugs, pharmacokinetic

aspects 540 20 Cancerous tissue 525 20 Cancerous tissue, damage 551

242

22 Candicidin 105 16 Candida bogoriensis 265 22 Candidin 95 22 Canesten® (c1otrimazole) 36 16 Cannabis 224 17 Canopar® (thenium) 130 17 Caparside® (arsenamide,

thiacetarsamide) 122 17 Caparsolate® (arsenamide,

thiacetarsamide) 122 17 Capillaria feliscati 159 19 Capillaria hepatica 58 17 Capillaria obsignata 159 17 Capillaria philippinensis 159 18 Capillaria philippinensis 195 20 Capillaria philippinensis 454 17 Capillariasis 159 18 Capillariasis 196, 202 20 Capillariasis 454 18 Capreomycin 212 22 Caprokol® (hexylresorcinol) 46 20 Captagon® (fenetylline) 396 20 Caramiphen (Panparnit®) 420 16 Carbachol 219,343 18 Carbamazepine (Tegretol®) 459 20 - 394 16 Carbamylphosphat-Synthetase 410 22 Carbenicillin (Pyopen®, Geopen®) 51 22 Carbimazole (Neomercazole®) 77 20 Carbinoxamine (Clistin®) 424 20 Carbochromen (Intensain®) 407 21 Carbon disulfide 187 17 Carbon tetrachloride (tetrachloromethane,

Benziform®, Necatorina®) 116, 136,276 22 - 46 22 Carbopol 273 16 Carboxydismutase 416 17 2-( 6-Carboxyhexyl)-3-octylcyc1opent-2-

enone 417 16 Carboxylesterase 370,404 16 Carboxypeptidase G, 436 22 Carbutamide (Nadisan®, Invenol®) 80 21 Carcinoma 317 16 Carcinostatic activity 51 20 Cardiac agents 404 18 Cardiac arrhythmia 393 19 Cardiac arrhythmia 247 17 Cardiac cells 34 17 Cardiac glycosides 66 20 Cardiazol® (pentetrazole) 397 17 Cardiolipine 78 20 Cardiomyopathy 37 17 Caricide® (diethylcarbamazine) 127 20 Carisoprodol 392 22 Carmustine 64 16 Carnitine 290 23 Carrageenan 33, 34 19 Casoni's Test 77 20 Catapresan® (clonidine) 413 16 Catatonia 345 17 Catecholamine 35

Index Vol. 16-23

16 Catechol-O-methyltransferase 345 18 Catharanthus roseus 414 18 Catharosine 411 17 Cation transport 65 22 Cefazolin (Ancef®, Kefzol®) 53 22 Cefoxitin(Mefoxin®) 53 22 Celbenin® (methicillin) 50 22 Celestone® (betamethasone) 74 20 Cell cycle 482, 523 16 Cell proliferation 74,75,76 16 B cells 73 16 T cells 73 20 Cell transport mechanisms 263 16 Cellular immunity 73 19 Cell-wall antigen 612 19 Cell-wall antigen preparation 620 22 Celospor® (cephacetrile) 53 21 Centchroman 324 16 Central nervous system (CNS) 195 19 Central nervous system (CNS) 301 20 Central nervous system (CNS)

stimulants 396 22 Cephacetrile (Celospor®) 53 22 Cephalexin (Ceporex®, Kefiex®) 53 19 Cephalic tetanus 443 19 Cephalic tetanus, clinical data 444 19 Cephalic tetanus, diagnosis 444 19 Cephalic tetanus, EMG data 447 19 Cephalic tetanus, treatment 444 22 Cephaloglycin (Kafocin®) 53 22 Cephaloridine (Ceporin®, Loridine®) 53 22 Cephalosporin C 52 16 Cephalothin (Kefiin®) 314 22 - 53 22 Cephradine (Anspor®, Velosef®) 53 22 Ceporex® (cephalexin) 53 22 Ceporin® (cephaloridine) 53 16 Ceruloplasmin 378 17 Cestodes 119 17 Cetarsol® (drocarbil) 121 16 CFR (Code of Federal Regulations) 196,

207 20 Chabertia 350 20 Chagas Disease (american

trypanosomiasis) 446 21 Chemical sterilization 343 23 Chemical structure 98, 200 23 Chemical structure 200 22 Chiniofon (Yatren®) 42 16 Chinolinsaure-Phosphoribosyl-

Transferase 402 20 Chiral centers 123 20 Chlamydial infections 355 20 Chloralhydrate 387 17 Chlorambucil (Leukeran®) 349 20 - 584 21 - 351 22 - 63 22 Chloramine T 29 16 Chloramphenicol (Chloromycetin®) 90,

1I8,318

Index Vol. 16-23

17 Chloramphenicol (Chloromycetinlll» 26, 488

18 - 331 19 - 511,519 21 - 174 22 - 54 16 d-Chloramphetamine 347 16 l-Chloramphetamine 347 18 Chlorasquin 116 17 Chlorcyclizine 25 22 Chlordantoin 131 18 Chlordiazepoxide (Libriumlll» 434 20 - 393 22 - 230,238,362 22 Chlordiazepoxide, degradation 238 18 Chlorguanide 107,328 22 Chlorhexidine 301 21 a-Chlorhydrin 355 20 Chlorisondamine (Ecolidlll» 202, 409 21 Chlormadinone acetate

(Gestafortinlll» 300, 308 22 - 74 22 Chlormethine (Dichiorenlll» 63 22 Chlormidazole 109 16 4-Chloroacetanilide 254,256,257,259 16 Chloroambucil 118 16 4-Chloroaniline 257 21 I-p-Chlorobenzyl-lH-indazol-3-carboxylic

acid (AF 1312/TS) 353 17 4-Chloro-a ,a' -bis( 5-chloro-2-

hydroxyphenyl)-2,6-xylenol (0-610) 295 17 5-Chloro-N -( 6-chloro-l ,2,3-

benzothiadiazol-7-yl)salicylamide 299 17 3' -Chloro-4' -(p-chlorophenoxy)-3,5-

diiodosalicylanilide (rafoxanide, Flukanidelll>, Novazolelll>, Ranidelll» 115, 135,165,272,282,283,298

17 3-Chloro-4-(p-chlorophenoxy)-4'­nitrocarbanilide 273

16 Chlorocruorin 382 17 7-Chloro-5a,l1a-dehydro-6-

epitetracycline 222 17 7-Chloro-6-demethyl-tetracycline 231 17 11a-Chloro-6-demethyltetracycline 218 16 6-Chloro-5-diethylaminoethylamino-8-

hydroxymethyl-quinoline 58 16 6-Chloro-5-diethylaminoethylamino-8-

methyl-quinoline 58 17 6-Chloro-5-{[2-( diethylamino )ethyl]­

amino}8-methylquinoline (RD 12.869) 254

17 8-Chloro-2-[-2-( diethylamino )ethyl]-2H­[ 1]benzothiopyrano[4,3,2-cd]indazole-5-methanol 249

17 4' -Chloro-3,5-diiodosalicylanilide, acetate of (2-acetoxy-4' -chloro-3,5-diiodobenzanilide, clioxanide, Tremeradlll» 114,135, 164,277,281

17 1-(2-Chloroethyl)aziridine 353 20 1-(2-Chloroethyl)aziridine 468 17 1-(2-Chloroethyl)-3-cyclohexyl-l­

nitrosourea 367

17 2-Chloroethyl isocyanate 367 17 1-(2-Chloroethyl)-3-(trans-4-

methylcyclohexyl)-l-nitrosourea 367 17 Chloroform 76 23 Chloroform 104 16 4-Chloroglycolanilide 256

243

22 Chloroguanide (proguanil, Paludrinelll» 44 16 Chlorolactanilide 252 22 Chioromycetinlll> (chloramphenicol) 54 17 2' -Chloro-4' -nitrosalicylanilide 297 16 4-Chlorooxanilic acid 256; 258 16 4-Chlorooxanilid 256, 258 18 Chloropentafiuoroethane 390 29 Chlorophene 29 16 Chlorophenesin 99 16 4'-ChlorophenyIacetanilide 263 16 p-Chlorophenylalanine 220 18 1-(p-Chlorophenyl)-3-[4-amino-6-(tri­

fiuoromethyl)-2-pyrimidinyl]guani­dines 147

18 1-(p-Chlorophenyl)-3-( 4-{[2-( diethyl­amino )ethyl]amino}-6-methyl-2-pyrimidinyl)guanidine (ICI-3,349) 132

17 1-(p-Chlorophenyl)-3- • pentanimidoylurea 307

16 4-Chloropropionanilide 251,253 17 6-Chloropurine 340,347 20 Chloropyramine (Synopenlll» 426 16 Chloroquine (Aralenlll» 100 18 - 103,184,249,324,363 19 - 52 20 - 435,439 22 - 42 18 Chloroquine diphosphate 102 22 Chlorotetracycline (Aureomycin®) 53 20 Chlorothiazide (Diurillll» 210,417 16 3-Chlorothioxanthenone 35 17 Chlorothricin 69 17 N' -(3-Chloro-p-tolyl)-N ,N-

diethylethylenediamine (mirasan) 250 22 Chlorotrianisene (Tracelll» 72 20 Chlorozotocin 480 22 Chlorphenesin 130 16 Chlorpheniramine (Chlor-Trimeton®) 342,

347 20 - 426 18 Chlorphenoxamide 361 16 Chlorpromazine (Largactil®) 91,344,345 17 - 23,25,490 18 - 433,455 19 - 210,225,246,289,323,330,362,439 20 - 389 21 - 413 23 - 117 22 Chlorpropamide (Diabineselll» 81 23 - 38 20 Chlorprothixene (Taractan®) 389 22 Chlorquinaldol 128 17 Chlortetracycline (7-chlortetracycline) 211,

214,217,228,231,234 18 - 331

244

20 Chlorthalidone (Hygroton4O) 210,417 20 Chlor-Trimeton4O (chlorpheniramine) 426 17 Chloxyle4O (hexachloroparaxylol) 117 17 Choanotaenia infundibulum 299,300 22 Cholecalciferol (vitamin 0 3) 86 18 Cholera 45 19 Cholera 347,352,471,519,542,578 23 Cholera 12 19 Cholera antiserum 516,550 19 Cholera antitoxin 604 19 Cholera bacteriology 514 19 Cholera biotypes 517 19 Cholera carrier 594 19 Cholera colonization 564 19 Cholera control 503 19 Cholera diagnosis 513 19 Cholera diarrhoea 543 19 Cholera enterotoxin 471,478 19 Cholera epidemiology 510,578,594 19 Cholera immunity 612 19 Cholera incidence 579 19 Cholera infection 471,490,564, 594 23 Cholera infection 13 19 Cholera pandemic 513 19 Cholera pathophysiology 563 19 Cholera research 503 19 Cholera sereotypes 353,517 19 Cholera therapeutics 563 19 Cholera toxin 504,519 20 Cholera toxin receptor 342 19 Cholera toxoid 602 19 Cholera toxoid lot 00101 603 19 Cholera toxoid lot 11201 605 19 Cholera toxoid purification 605 19 Cholera toxoid research 602 19 Cholera treatment 503 19 Cholera vaccines 275,277,278,353,481,

503,509,547,550,554,602 23 Cholera vaccines 13 23 Cholera vibrios 13 16 Choleragen 430 16 Cholesterin-Esterase 414 17 Cholesterol 72, 77 20 Cholesterol 287,296 20 Cholestyramine (Questran4O) 418 16 Cholinacetylase 335 16 Cholinergic mechanisms 335 16 Cholinesterase 336 19 Cholinesterase 329 19 Cholinesterase inhibitor 329 16 Choriogonadotropin 374 16 Chorismatmutase-Prephenat-

Dehydrogenase 390 21 Chronic toxicity 135, 164 16 Chymotrypsin 112, 388 23 Chymotrypsin 141, 152 16 Chymotrypsin-Inhibitor 374 17 CI-407 (5-(4-{l2-

(diethylamino )ethyllamin<l-I­naphthylazo )uracil) 255

Index Vol. 16-23

18 CI-50l (cycloguanil pamoate, Camolar4D) 107, 156

18 CI-679 (2,4-diamino-6-[(3,4-dichloro­benzyl)nitrosamino lquinazoline acetate) 151

22 CIBA 190640 (thiambutosine) 36 22 Cibazol4O (sulfathiazole) 31 22 Cicloperox 128 20 Cimetidine 427 23 Cimetidine 54 16 Cinanserin 99 20 Cinchocaine (Nupercaine4O) 403 20 Cinnarizine (Stutgeron4O) 426 21 Cinnoline derivates 46 21 Cinoxacin 46 16 Citral acid 242 16 Citrat-Oxalacetat-Lyase 442 16 Citrat-Synthase 394,410 19 Citric acid 284 16 d-Citronellic acid 242 22 Clavulanic acid 53 18 Cleavamine 413 20 Clemastine (Tavegyl4O) 424 20 Clemizole (Allercur4O) 426 22 Cleocin4O (clindamycin) 59 20 Clindamycin (Cleocin4O) 436 22 - 59 23 Clinical dextran 30, 33 20 Clinical evaluation 151 20 Clinical pharmacology 17, 151 22 Clinical pharmacology II 22 Clinical research 18 22 Clinical studies 10 21 Clinical trials 246 20 Clinoril4O (sulindac) 402 22 Clioquinol (Vioform4O) 42 16 Clioxanide (2-acetoxy-4'-chloro-3,5-

diiodobenzanilide, 4' -chloro-3,5-diiodosalicylanilide acetate, Tremerad4O) 172

17 - 114,135,164,277,281 20 Clistin40 (carbonoxamine) 424 22 Clobazam (Urbanyl4O) 258 22 Clofazimine (Lamprene4O) 38 20 Clofibrate (Atromid-S) 418 18 Clofluperidol 437 21 Clogestone 308,321 22 Clomid4O (clomiphene) 72 22 Clomiphene (Clomid4O) 72 22 Clomipramine 365 22 Clonazepam (Clonopin4O) 261 20 Clonidine (Catapresan4O) 220,413 23 - 217 22 Clonopin4O (clonazepam) 261 17 Clonorchiasis 138,276 17 Clonorchis sinensis 138, 276 18 Clonorchis sinensis 196 20 Clonorchis sinensis 450 17 Clont4O (metronidazole) 125 20 Clopamide (Brinaldix4O) 210,417

Index Vol. 16-23

21 Cloprostenol 326 22 Clorazepate (Tranxene®) 245 20 Clorexolone 210 20 Clorindione (Indalitan®) 404 19 Clostridium diphtheriae 241, 336 16 Clostridium histolyticum 293 19 Clostridium tetani 241,392 19 Clostridium tetani growth 384,386 19 Clostridium tetani spores 388 19 Clostridium welchii 546 22 Clotiazepam 257 22 Clotrimazole (Canestan®, Lotrimin®) 36,

109, 117 16 Cloxacillin (Orbenin®, Tegopen®) 314 22 - 50 22 Cloxazolam (Sepazon®) 252 20 Clozapine (Leponex®) 391 21 - 413 20 CMT-Selectines 553 16 CNS (Central nervous system) 195 23 CNS activity 212 16 Coagulase 314 17 Cocaine 75 20 Cocaine 403 20 Coccidosis 438 16 Code of Federal Regulations (CFR) 196,

207 22 Codeine 152 23 Codeine 116 22 Codeinone 152 22 Colcemid® (demecolcin) 64 16 Colchicine 85, 86 20 Colchicine 403, 585 21 Colchicine 351 22 Colchicine 64 19 Coliform bacilli 280 16 Collagen 378 16 Collagen biosynthesis 292 16 Collagenase 293 23 Collander equation 102 23 Colocynthin 68 20 Combantrin® (pyrantel pamoate) 451 18 Communicable diseases 44,278 18 Communicable diseases control 44,46,

243,278 19 Complement fixation test 124, 133 19 Complement fixing antibody 179 16 Concanavalin A 112,370, 376,430 20 Concanavalin A 328 23 Concanavalin A 33, 35, 38, 139 22 Congasine (Surfen C®) 42 22 Conteben® (thiacetazone) 34 21 Contraception 295 17 Contraceptive 457 21 Contraceptive action 309 21 Contraceptive pill 244 21 Contraceptive vaccines 359 23 Convolvulin 71 19 Convulsions 305 21 Copper Lippes Loop 332 21 Copper seven 331

21 Copper T 330 17 Co-Ral® (coumaphos) 129 20 Coramine® (nikethamide) 397 23 Corasil C-18® 125 17 Coriban® (diamphenethide,

diamfenethide) 118,286 17 Coronary occlusion 39 17 Corpus luteum 458 16 Corticosteroids 91 20 Corticosteroids 584 21 Corticosteroids 243 22 Corticotropin 79 18 Cortisol (hydrocortisone) 429 22 Cortisol (hydrocortisone) 68, 74 18 Cortisone 429 20 Cortisone 454, 475 22 Cortisone 74 22 Cortivazol (Diaster®) 75 16 Corynebacterium diphtheriae 287 19 Corynebacterium diphtheriae 283 23 Corynebacterium parvum 15 17 Corystibin® (stibophen) 112 22 Cosmegen® (dactinomycin) 67 17 Cotugnia digonopora 294 20 Coumadin® (warfarin) 404 16 Coumaphos (Baymix®, Co-Ral®,

Asuntol®) 168 17 - 129,158,159,163 17 Coumarin 493 17 Coumarin metabolism 493 22 Crasnitin® (asparaginase) 67 18 Crilhidiajasciculata 299 20 Crohn's disease 361 20 Cromolyn sodium (lntal®) 427 23 Crotepoxide 77 16 Crotonase 402 16 a-Crustacyanin 380 16 p-Crustacyanin 380 16 y-Crustacyanin 380 18 Culexjatigans 174,271,284 18 Culex pipiens 260 19 Curare 250,296,324 19 Curarisation 248 17 Cyanacethydrazide (Cydrazin®,

Dictycide®, Neohydrazid®) 131,177 17 Cyanide 496 22 Cyanidol 312

245

17 4-Cyano-2-iodo-6-nitrophenol (nitroxynil, Trodax®) 117,136,278,280

17 Cyanuric acid 361 17 Cyclase reaction, modulators of 468 20 Cyclazocine 76,81,93 22 Cyclazocine 160 20 Cyclazocine glucuronide 77 20 Cyclizine (Marezine®) 426 22 Cyclocytidine 294 18 Cycloguanil pamoate (Camolar®, CI-

501) 107, 156,327,328 20 - 435,444 22 - 44 23 Cyclohexane 105

246

17 Cyclohexylisocyanate 367 16 Cycloleucine (I-aminocyclopentane

carboxylic acid) 88 22 Cyclooctylamine hydrochloride (SKF

23880A) 279 20 Cyclopenthiazide (N avidrex®) 417 16 Cyclophosphamide (Cytoxan®,

Endoxan®) 86,103,117 17 - 305,306,350 20 - 468,583 21 - 199,351 22 - 64 17 I'C-Cyclophosphamide 356 18 Cyclophosphoramide 23 23 Cycloprotobuxine-C 86 20 Cyclorphan 60 18 Cycloserine (Seromycin®) 212 22 - 55 20 Cyclothiazide 210 17 Cydrazin® (cyanacethydrazide) 131 20 Cyproheptadine (Periactin®) 426 23 - 40 21 Cyproterone 22 Cyproterone acetate (Androcur®) 70 18 Cyrofluorane

(dichlorotetraftuoroethane) 378 16 Cystathionase 438 16 Cystathionin-Synthetase 410 16 Cystathionin-)l-Synthetase 402 16 Cysteamin-Oxygenase 394 20 L-Cysteine 480 16 Cystein-Synthetase 412 18 Cysticercosis 279 20 Cysticercosis 448 22 Cytarabine (Cytosar®) 64 16 ara-Cytidine 96, 103, 123 16 Cytidintriphosphat-Synthetase 396 20 Cytochalasin B 586 22 Cytochalasin B 311 19 Cytochrome 308 17 Cytochrome a, 492 16 Cytochrome bs 248 17 Cytochrome bs 497 16 Cytochrom cc' 432 16 Cytochrom f 378 16 Cytochrom C-Oxydase 404 16 Cytochrome P-450 248,306 17 Cytochrome P-450 489 19 Cytochromeoxidase 319 17 Cytoplasm 63 16 Cytoplasmaprotein 432 22 Cytosar® (cytarabine) 64 17 Cytosine arabinonucleotide 334 20 Cytostatic therapy 357 20 Cytotoxicity 482 22 Cytoxan® (cyclophosphamide) 64 17 Cytoxylamine 351

D 22 Dacarbazine 64 22 Dactin® 29

Index Vol. 16-23

17 Dactinomycin (actinomycin, Cosme-gen®) 376

22 - 67 22 Daktarin® (miconazole) 36 21 Dalkon® shield 334 22 Dalmane® (llurazepam) 261 21 Danazol 349 20 Danilone® (phenindione) 404 20 Dantrium® (dantrolene) 422 20 Dantrolene (Dantrium®) 422 22 Daoni\® (glibenclamide) 81 18 Dapolar® (acedapson + cycloguanyl

pamoate) 108, 157 18 Dapsone (Avlosulfone®) 155, 159 20 - 435 22 - 33 20 Daptazole® (amiphenazole) 397 20 Daraprim® (pyrimethamine) 435 22 Daraprim® (pyrimethamine) 44 21 Darbid® 357 20 Darvon® (dextropropoxyphene) 399 22 - 189 22 Daunoblastine® (daunorubicin) 67 18 Daunomycin 441 20 Daunomycin 474 18 Daunomycinone 441 17 Daunorubicin (Daunoblastin®) 373 22 - 67 17 Daunorubicinol 374 17 Davainea proglottina 299 20 DCI (dichbroisoproterenol) 28,32,224 16 dCMP (Deoxycytidin Monophosphat)

Aminohydrolase 398 16 DDT [I, 1,1-Trichloro-2,2-bis-(p-chloro­

phenyl)ethane; dichlorodiphenyltrichlo­roethane 1 351

17 - 497 18 - 248,267,284 21 -.124, 185 16 DDT-dehydrochlorinase 436 16 DDVP (Dichlorvos) 158, 168 17 Deacetylcolchicine 381 18 Deacetylvindoline 411 20 Death, causes of 501 20 Death statistics 494 17 7-Deazainosine 345 22 Debenal® (sulfadiazine) 31 20 Debrisoquine (Declinax®) 215,410 22 - 356 18 DEC (diethylcarqamazine) 142,179,201,

260,275 22 Decadron® (dexamethasone) 74 22 Deca-Durabolin® (nandrolone deca-

noate) 69 19 Deca-methonium succinylcholine 296 16 Decane-I, IO-dioic acid 235 16 Decanoid acid 244,246 19 Decarboxylase media 516 19 Decarboxylase tests 515 16 Decarboxylation 277 20 Decaserpyl® (methoserpidine) 408

Index Vol. 16-23

20 DeclinaxllD (debrisoquine) 410 22 DecodermllD (tluprednylidene acetate) 75 22 DecortilenllD (prednylidene) 75 16 Decosanoic acid 267 23 Decumbrin 88 16 2-Decylcitrat-Synthetase 436 17 Dedimethylamino-7-chloroanhydro-tetra­

cycline 224 17 Dedimethylamino-12a-deoxyanhydro-6-

demethyltetracycline 224 17 Dedimethylamino-6,12a-dideoxyde-car­

boxamido-7-chlorotetracycline 224 17 Dedimethylamino-6,12a-dideoxy-6-deme-

thyltetracycline 224 19 Dehydration 504 17 5a, lla-Dehydro-7-chlorotetracycline 232 17 Dehydroemetine 113, 133, 141, 144 18 Dehydroemetine 360 20 Dehydroemetine 450 18 2-Dehydroemetine 325 16 Dehydrogenation 287 17 ll-Dehydroprostaglandin Fl. 439 17 DekeIminllD (methyridine) 123 22 DelalutinllD (hydroxyprogesterone

caproate) 73 22 Delta-9-tetrahydrocannabinol 365 22 DelvexllD (dithiazanine) 48 17 Demeclocycline (6-demethyl-7-chlorote-

tracycline) 211, 228, 236 22 Demecolcin (ColcemidllD) 64 17 6-Demethyl-6-deoxytetracycline 224 17 6-Demethyltetracycline 216 18 Dengue 284 18 Dengue fever 45 23 De Novo model 201 17 3'-Deoxyadenosine 345 17 12a-Deoxyanhydrotetracycline 226 17 2'-Deoxy-5-azacytidine 326 22 Deoxycorticosterone 76 17 6-Deoxy-6-demethyltetracycline 218 17 2'-Deoxy-5-tluorocytidine 332 17 2'-Deoxy-5-tluorouridine 329 17 2'-Deoxy-5-tluorouridylic acid 329 23 2-Deoxyglucose 40 22 2-Deoxy-o-glucose 306 23 Deoxyharringtonine 86 17 3'-Deoxyinosine 345 17 p-6-Deoxytetracycline 218 17 2'-Deoxy-6-thioguanosine 341 17 2'-Deoxy-5-tritluoromethyluridine 332 20 DepakinellD (sodium dipropylacetat) 424 21 Depomedroxyprogesterone acetate

(DMPA) 302 22 Dequalinium chloride 129 20 Dermatitis 589 16 DES (Drug Efficacy·Study) 200 16 Desaggregierung 367 17 Desaspidin (RosapinllD) 120, 148 16 Deserpidine (HarmonylllD) 352

20 - 208,408 16 DESI (DES Implementation) 201 16 DES Implementation (DESI) 201 16 Desipramine 340, 352 22 Desipramine 364 22 Desmethyldiazepam (MadarllD) 262 17 Desmethylimipramine 25 22 N-Desmethylmethadone 190 22 Desoxymethasone (TopisolonllD) 74 16 Desoxynucleotid:Polymerase 388 19 Desperidine 153 16 Dethiobiotin-Synthetase 388 19 Deworming 136 19 Dexamethasone (DecadronllD) 362 22 - 74 20 Dexamisole 349 16 Dexamphetamine 346 22 Dexamphetamine 364 23 Dextran 28,30,41 23 Dextrin 47

247

22 Dextromoramide (PalfiumllD, letriumllD) 189 20 Dextropropoxyphene (DoloxenellD, Dar-

vonllD, DistalgesicllD) 399 22 - 189 22 Dezocine 207 20 Diabetes, insulin resistance of 329 22 DiabinesellD (chlorpropamide) 81 17 3',5' -Di-O-acetyl-2' -deoxy-5-tluorouri­

dine 331 17 Diacetylphenylurea bis(guanyl-hydra-

zone) 377 16 Diacetyl-Reductase 396 17 3',5'-Di-O-acetylthymidine 331 17 2,2'-Diacyloxybenzanilides 298 17 N-[(Dialkylamino )alkyl)-I,4-naphthalene­

diamines 258 16 a-Dialkylaminosaure-Amino-Trans­

ferase 438 17 N,N-Dialkyl-N'-(I-naphthyl)alkylene­

diamines 256 17 N,N-Dialkyl-N'-phenyl-N'-[(I,I,2,2-

tetrachloro-2-tluoroethyl)thio )sulph­amides 308

17 Diamfenethide (CoribanllD) 286 18 2,4-Diamino-6-[(N-alkylanilino )methyl)­

quinazolines 116 18 2,4-Diamino-6-[(anilino)methyl)quinazo­

lines 116 18 2,4-Diamino-6-[(aryl and heterocyclic)sul­

finyl)quinazolines 121 18 2,4-Diamino-6-[(aryl and heterocyclic)sul­

fonyl)quinazolines 121 18 2,4-Diamino-6-[(aryl and heterocyclic)­

thio )quinazolines 121 22 Diaminobenzophenones 274 18 2,4-Diamino-6-[(p-chloroanilino)­

methyl)quinazolines 118 18 2,4-Diamino-6-[(p-chlorobenzyl)oxy)­

quinazoline 120

248

18 2,4-Diamino-5-(p-chlorophenoxy)-6-methylpyrimidine 109

18 2,4-Diamino-6-(p-chlorophenoxy)quin­azoline 121

18 2,4-Diamino-6-[(p-chlorophenyl)thio)­quinazoline (WR-135,403) 129

18 2,4-Diamino-6-[(3,4-dichlorobenzyl)ami­no)quinazolines 115, 118

18 2,4-Diamino-6-[(3,4-dichlorobenzyl)ami­no)quinazoline (PAM-l,392) 110

18 2,4-Diamino-6-[(3,4-dichlorobenzyl)nitros­amino)quinazoline acetate (CI-679) 151

18 2,4-Diamino-6-(3,4-dichlorophenoxy)­quinazoline 121

18 Diaminodiphenyl sulfone (4,4'-sulfonyl­dianiline, dapsone) 108, 155

22 2,7-Diaminoftuorenone 274 18 2,4-Diamino-6-(heterocyclic )quinazo­

lines 119 18 2,4-Diamino-6-(2-naphthylsulfonyl)quin-

azoline (WR-158,122) 130 22 Diamorphine 211 20 Diamoxlll> (acetazolamide) 417 17 Diamphenethide (Coribanlll» 118, 137,286 22 Diamthazole hydrochloride 130 22 Dianabollll> (methandienone) 6,68 17 Diarrhea 460 19 Diarrhoea 482,491,504,519,526,527,570 19 Diarrhoea syndroms 528 19 Diarrhoea therapy 527 19 Diarrhoea treatment 532 22 Diasterlll> (cortivazol) 75 18 Diaveridine 108 22 Diazaditwistane 209 18 Diazepam (Valiumlil ) 434 19 - 210,225,246,297,362,379 20 - 393,422 22 - 230,242,356 16 N-Diazoacetyl-glycine amide 88 17 5-Diazoimidazole-4-carboxamide 341 16 6-Diazo-5-oxo-L-norleucine (DON) 88 17 6-Diazo-5-oxo-L-norleucine (DON) 323 20 6-Diazo-5-oxo-L-norleucine (DON) 470 20 Diazoxide 232, 233, 244 20 Dibenamine 414 20 Dibenzepin (Noverillll» 394 21 Dibenzodiazepine derivatives 442 17 Dibenzoxazepine derivatives 469 21 Dibenzoxazepine derivatives 442 19 Dibenzylamine 155 17 3,4' -Dibromo-5-chlorothiosalicylanilide,

acetate of (Bayer 4059, brotianide, Dirianlil ) 115, 136,284

17 N, N-Di-n-butyl-4-n-hexyloxy-l-naph-thamidine (bunamidine, Scoloban lil ) 302

17 Di-n-butyltin dichloride 294 17 Di-n-butyltin oxide 293 17 Dicestallil (dichlorophene) 121 21 Dichlofenthion 179 22 Dichlorenlil (chlormethine) 63 20 Dichlorisoprenaline 225,411

Index Vol. 16-23

17 N-(2,4-Dichlorobenzylidene)-N' -[2-( di­ethylamino )ethyl)-I ,4-naphthalene­diamine 256

21 1-(2,4-Dichlorobenzyl)-indazole-3-carbox­ylic acid (AF 1890) 354

18 Dichlorodiftuoromethane 384 17 5,5' -Dichloro-3,3' -dinitro-2,2' -biphenyldiol

(menichlopholan, Bilevonlll>, Bayer 9015) 278

20 Dichloroisoproterenol (DCI) 28, 32, 224 16 Dichloromethotrexate 93 17 Dichloromethotrexate 324 18 Dichloromethotrexate 23 18 Dichloromonoftuoromethane 374 17 2',5-Dichloro-4' -nitrosalicylanilide (niclos­

amide, phenasal, Yomesanlll» 119, 138, 139,148-154,296,297

17 Dichlorophen(e) (Anthiphenlll>, Dicestallll>, Theniathanelil , Vermiplexlll» 121, 152, 155, 295

20 - 447 22 - 46 17 DL-erythro-a-(3,4-Dichlorophenyl)-p-(t­

butylamino)-propanol HCL (B.W. 65-54) 25

18 1-(3,4-Dichlorophenyl)-3-(4-{3-[(diethyl­amino )methyl)-p-anisidino}-6-( triftuorome­thyl)-2-pyrimidinyl)guanidine (FI-345) 150

18 1-(3,4-Dichlorophenyl)-3-{4-[( l-ethyl-3-piperidyl)amino )-6-methyl-2-pyrimidinyl}­guanidine (WR-81,844) 140

17 2,4-Dichloro-6-phenylphenoxyethylamine HCl (DPEA, Lilly 32391) 19

17 2,4-Dichloro-6-phenyl-phenoxyethyl-di­ethylamine HBr (Lilly 18947) 19

17 6,8-Dichloro-2-phenyl-a-(2-piperidyl)-4-quinolinemethanol (SN-IO,275) 270

17 7,l1a-DichlorotetracycIine 217 18 Dichlorotetraftuoroethane (cyroftuo­

rane) 378 17 2,2-Dichlorovinyl methy14-phenylbutyl

phosphate 306 17 2,2-Dichlorovinylphosphates 306 17 Dichlorovos (see Dichlorvos) 307 16 Dichlorvos (DDVP, Atgardlil , Tasklil ,

Vaponalll» 158, 168 17 - 128, 157, 161, 164, 167, 170, 175,307 17 Dichlosale 148 20 DicIofenac sodium (Voltaren lil ) 401 22 Diconallll> (cyclizine+dipipanone) 189 20 Dicoumarol (Dicumanlll» 404 17 Dicrocoeliasis 132, 276 17 Dicrocoelium dentriticum 276 17 Dicrodenlil (hetolin) 118 17 Dictycidelll> (cyanacethydrazide) 131 17 Dictyocauliasis 176 20 Dictyocaulus 350 17 Dictyocaulus filaria 176 17 Dictyocaulus viviparus 176 20 Dicumanlil (dicoumarol) 404 17 Dieldrin 24

Index Vol. 16-23

21 Dieldrin 181 21 Dienestrol 319 17 5-( 4-{(2-(Diethylamino )ethyl]amino }-I­

naphthylazo)uracil (CI-407) 255 17 N -( 4-{(2-(Diethylamino )ethyl]amino }-I­

naphthyl)octanamide 257 17 6-{(2-(Diethylamino )ethyl]amino }-1,2,3,4-

tetrahydro-12H-benzo[a]thioxanthen-12-one 250

17 2-DiethylaminoethyI2,2-diphenylvalerate HCI (SKF 525-A) 13

17 2-[2-(Diethylamino )ethyl]-5-methyl-2H­[1]benzothiopyrano[4,3,2-cdJindazole 249

16 Diethylcarbamazine (Banocide®, Carici­de®, Ditrazin®, Loxuran®, Notezine®, Hetrazan®) 173

17 - 127, 176, 178, 180, 181, 182, 183, 185 18 - 142,179,201,260,275 19 - 50, 151 20 - 455 22 - 48 21 1-(N,N-Diethylcarbamyl-methyl)-2,4-dini­

tropyrrole (ORF 1616) 352 17 Diethyldithiocarbamate 24, 496 17 O,O-Diethyl-3-methoxy-2-quinoxalinyl

phosphorothioate 307 17 N,N-Diethyl-N' -(4-nitroso-I-naphthyl)-

ethylenediamine 258 20 Diethylstilbestrol 475 21 Diethylstilbestrol 243,318 22 Diethylstilbestrol 72 23 Diethylstilbestrol 57 17 I, I-Difluoro-2,2-dichloroethyl methyl

ether (methoxyflurane) 16 18 Difluoroethane 391 20 Digitoxin 404 17 Digoxin 47,306 21 Digoxin 115, 116 17 Dihomo-y-linolenic acid 430 20 Dihydralazine (Nepresol®) 205,409 17 Dihydroaldrin 24 20 Dihydroergocornine 415 20 Dihydroergocristine 415 20 Dihydroergocryptine 415 17 Dihydrofluorouracil 329 23 Dihydrofolate reductase 60 22 Dihydrogesterone (Duphastone®) 74 22 2,3-Dihydro-IH-imidazo[I,2-b]pyra-

zole 288 22 Dihydro-isoquinolines 286 17 5,8-Dihydro-5,8-methano-I,4-naphtho-

quinonedialkanesulphonimides 309 17 Dihydro-prostaglandin EI 446 17 Dihydroprostaglandin E, 452 17 13, 14-Dihydroprostaglandin EI 441 17 13, 14-Dihydroprostaglandin F2a 444 22 Dihydrotachysterol 84 22 Dihydrothebainone 153 17 9a, lla-Dihydroxy-15-oxoprost-5-enoic

acid 453 17 Sa,7a-Dihydroxy-II-oxo-tetranorprosta-

1,16-dioic acid 452

17 Sa,7a-Dihydroxy-ll-oxo-tetranorprosta-noic acid 433, 445, 452

21 Dihydroxyphenylacetic acid 414 16 Dihydroxyphenylalanine 220 16 3,4-Dihydroxyphenylglycol 348 22 Diiodohydroxyquine (Diodoquin®) 42 20 Diiodohydroxyquinoline (Diodo-

quin®) 438

249

17 2,6-Diiodo-4-nitrophenol (disophenol, An­cylol®, DNP, Disofen®) 131,162,171,177, 278,280

16 Diisopropyl-fluorophosphate 219 16 Diisopropyl-phosphofluoridate 343 16 Diisopropyl-phosphorofluoridate 356 17 4,4'-Diisothiocyanatodiphenyl sul-

phone 301 17 trans-I,4-Di[ (2-isothiocyanato )ethyl]cyclo­

hexane (R.P. 14015) 300 16 Dilantin® (diphenylhydantoin, pheny-

toin) 123 20 Dilantin® (diphenylhydantoin) 387 17 Dilantin® (diphenylhydantoin) 224 18 Diloxanide 361 20 Diloxanide fuorate (Furamide®) 438 17 Dimercaprol 244 20 Dimercaptol (BAL) 446 20 Dimethindene (Fenostil®) 426 18 Dimethisterone 449 16 2,2-Dimethyladipic acid 237 16 y-(Dimethylamino) -butyric acid 290 17 7-Dimethylamino-6-demethyl-6-deoxyte­

tracycline 220 22 4-Dimethylamino-2,2-diphenylvaleric

acid 191 17 5-(Dimethylamino )-2-nitrosophenol 260 16 7,12-Dimethylbenz[a]anthracene

(DMBA) 98 16 2,2-Dimethylgluratic acid 237 16 2,2-Dimethylheptane-I,7-dioic acid 237 17 O,O-Dimethyl-I-hydroxy-2,2,2-trichloro-

ethylphosphonate (Dipterex®; trichlor­phon; metrifonate) 268

16 [8- 14C]-3,6-Dimethyloctanoic acid 239, 284,285

16 2,2-Dimethyloctanoic acid- J-14C 245 23 2,4-Dimethylpentane 127 21 16,16-Dimethyl-PGE, 372 22 2,6-Dimethyl-4-phenylpiperidin-4-o1 177 17 3,3-Dimethyl-l-phenyltriazene 368,369 17 Dimethylsulfoxide (DMSO) 16 21 Dimethylsulfoxide (DMSO) 186 16 5,6-Dimethyl-4,5,6,7-tetrahydro-

pterine 284 17 N,N -Dimethyl-2-thiophenepropionami­

dine 308 17 5-(3,3-Dimethyl-I-triazeno )imidazole-4-

carboxamide 369 19 4-a-Dimethyl-tyramine 149 18 Diminazene (Berenil®) 320 22 - 42 17 Dinactin 68

250

17 4,4' -Dinitrocarbanilide 273 16 Dinitrochlorobenzene (DNCB) 88 17 Dinitrofluorobenzene 70 17 Dinitrophenol 65 17 a-Dinor-prostanoic acid 420 22 N,N-Dioctadecyl-N',N'-bis(2-hydroxy­

ethyl)-propanediamine 275 20 Diodoquin® (diiodohydroxyquine, diiodo­

hydroxyquinoline) 438 22 Diodoquin® (diiodohydroxyquine, diiodo-

hydroxyquinoline) 42 16 Dioleylgiyceryl-3-phosphoryicholine 248 20 1,3-Dioxolane derivatives 109 16 Dipeptidyl-Transferase 404 18 Dipetalonema perstans 201,260 18 Dipetalonema witei 261 20 Diphemanil (Prantal®) 420 20 Diphenhydramine (Benadryl®) 424 20 Diphenhydramine derivatives 220 20 Diphenhydramine derivatives 108 16 p-Diphenol-Oxidase 390 22 Diphenoxylate (Lomotil®) 195 22 1,2-Diphenylethylpiperazines 206 16 Diphenylhydantoin (phenytoin, Dilan-

tin®) 123,213,223 17 - 47,51 18 - 456 20 - 387 23 - 114 16 Diphenylhydramine 342 22 2,6-Diphenyl-3-methyl-2,3-dihydroimida-

zo-[2,I-b)thiazole 288 17 4,7-Diphenyl-I,IO-phenanthroline 14 22 3,3-Diphenylpropylamine derivatives 189 20 Diphenylpyraline (Hispril®) 424 17 2,2-DiphenylvaJeric acid (SKF 2314) 18 16 Diphetarsone (Amebarsin®, Bemarsal®,

Rodameb®) 173 17 - 123,174 19 - 36 20 - 453 16 Diphezyl (difesyl, difesil) 170 17 Diphezyl (difesyl, difesil) 130, 175 19 Diphtheria 241, 256, 336, 347, 356, 412,

452 23 Diphtheria II, 17 19 Diphtheria, age incidence 425,452 19 Diphtheria, age profile 412 19 Diphtheria, bacteriological studies 427 19 Diphtheria, clinical type 426 19 Diphtheria, complications 428 19 Diphtheria, death 429 19 Diphtheria, diagnosis 419,452 19 Diphtheria, epidemiology 336 19 Diphtheria, immunization 358, 4!4, 455 19 Diphtheria, mortality 423 19 Diphtheria, seasonal incidence 434, 452 19 Diphtheria strains 241,428 19 Diphtheria symptoms 426 19 Diphtheria toxin 283 19 Diphtheria toxin production 284

Index Vol. 16-23

19 Diphtheria toxoids 274 19 Diphtheria vaccines 229 17 Diphyllobothriasis 148 17 Diphyllobothrium latum 148,292 18 Diphyllobothrium larum 198 20 Diphyllobothrium latum 447 22 Dipipanone 189 20 Diprenorphine 88 22 Diprenorphine 156 17 Dipterex® (metrifonate, trichlorfon) 268 22 Dipterex® (metrifonate, trichlorfon) 47 17 Dipylidiasis 149,293 17 Dipylidium caninum 300 17 Dipyridamole (Persantin®) 74 20 - 406 17 a,a'-Dipyridyl 496 17 Dirian® (3,4' -dibromo-5-chlorothiosali­

cylanilide acetate, Bayer 4059 brotia­nide) liS, 136,284

18 Dirofilaria immitis 143,261 19 Dirofilaria immitis 128 17 Dirofilariasis 181 20 Diseases, international classification 492 16 Diskelektrophorese 366 20 Disodium cromoglycate (DSCG) 589 23 Disodium cromoglycate (DSCG) 42 17 Disofen® (disophenol) 131 17 Disophenol (2,6-diiodo-4-nitrophenol, An­

cylol®, DNP, Disofen) 131,162,171,177, 278,280

21 Disopyramide 112 16 Dissoziation 367 16 Dissoziationsmittel 366 22 Distalgesic® (dextropropoxyphene) 189 16 Distoma haematobium 12 20 Distomer 105 17 N ,N-Disubstituted-N' -(5-nitro-2-thia-

zolyl)oxamides 263 16 Disulfidbriicken 367 17 Disulfiram 24, 26 16 Disulphiram 220, 349 17 Dithiazanine (Anelmid®, Dizan®, Tel-

mid®) 127,170,171,175 19 Dithiazine (Delvex®) 154 22 - 48 17 Dithiocarbamic acid esters 288 17 Ditrazin® (diethylcarbamazine) 127 20 Diuretics 208, 243, 415 20 Diuril® (chlorothiazide) 417 17 Dizan® (dithiazanine) 127 16 DMBA (7,12-dimethylbenz[a)an-

thracene) 98 17 DMSO (dimethylsulfoxide) 16 21 DMSO (dimethylsulfoxide) 186 16 DNCB (dinitrochlorobenzene) 88 20 Dogrnatil® (sulpiride) 391 20 Dolantin® (meperidine, pethidine) 398 22 Dolantin® (meperidine,

pethidine) 168 22 Doloxene® (dextropropoxyphene) 189 22 Domar® (pinazepam) 262 16 DON (6-diazo-5-oxo-L-norleucine) 88

Index Vol. 16-23

17 DON (6-diazo-5-oxo-L-norleucine) 323 20 DON (6-diazo-5-oxo-L-norleucine) 470 16 Dopa 346 16 L-Dopa 340,343,344,349 20 L-Dopa 423 23 L-Dopa O-methyl ester 78 16 Dopamine 336, 345 17 Dopamine 491 19 Dopamine 149 20 Dopamine 423 21 Dopamine 410 21 Dopamine analogs 422 16 Dopamine-p-hydroxylase 338, 345 21 Dopamine receptors 410 21 Dopamine receptor agonist 422 21 Dopamine receptor antagonist 438 21 Dopamine synthesis 411 16 Dopaminergic receptors 346 20 Dopram® (doxapram) 397 20 Doriden® (glutethimide) 387 21 Dowtherm A ® 36 20 Doxapram (Dopram®) 397 20 Doxepin (Sinequan®) 394 22 Doxorubicin (adriamycin) 67 17 Doxycycline (Vibramycin®) 211, 212, 228,

236 22 - 53 17 DPEA (Lilly 32391, 2,4-dichloro-6-phenyl-

phenoxyethylamine HCl) 19 17 DPH (diphenylhydantoin) 47,51 18 Dracontiasis 202 20 Dracontiasis 548 17 Dracunculiasis 178 18 Dracunculus medinensis 195 20 Dracunculus medinensis 458 23 Dreiding models 222 17 Drocarbil (Cetarsol®, Larumen®, Neumu-

ral®, Tenoban®) 121, 149, 154 22 Drolban® (drostanolone propionate) 69 20 Droleptan® (droperidol) 391 22 Dromoran® (Ievorphanol) 166 22 Droncit® (praziquantel) 49 18 Droperidol (Droleptan®) 437 20 - 391 22 - 185 22 Drostanolone propionate (Drolban®) 69 20 Drug abuse 22 22 Drug abuse 23 17 Drug action 66 21 Drug adverse reactions 233,237 21 Drug adverse reactions, causality 274 21 Drug adverse reactions, data 239,276 21 Drug adverse reactions, evaluation 238 21 Drug adverse reactions, mechanism 274 21 Drug adverse reactions, reports 264 21 Drug adverse reactions, severity 274 21 Drug concentration 113, 127 22 Drug consumer 21 20 Drug delivery 160, 175 21 Drug delivery systems 380 16 Drug development 196

20 Drug development 155, 160, 175, 182 16 Drug discovery 198 20 Drug discovery 160, 174, 184 23 Drug discovery 51 20 Drug efficacy 19 16 Drug efficacy study (DES) 200 19 Drug introduction 182 22 Drug manufacturer 18 17 Drug metabolism 12 20 Drug metabolism 11, 477 23 Drug metabolism 100 17 Drug metabolism inhibition 12, 18,21 17 Drug metabolism inhibitors 20 21 Drug monitoring 237 21 Drug monitoring centres 256 21 Drug monitoring characteristics 259 21 Drug monitoring concepts 240 21 Drug monitoring systems 239,282 23 Drug partitioning 156 20 Drug receptor 324 23 Drug receptor 99, 205 20 Drug receptor interaction 128 20 Drug receptor isolation 325 23 Drug receptor 205 20 Drug regulation 18 22 Drug-regulatory agency 19 20 Drug research, influences on 160 16 Drug research 195 20 Drug research 10, 160, 182 22 Drug retailer 19 16 Drug selection 198 20 Drug side effects 10 20 Drug structures 14 21 Drug terminology 273 21 Drug therapy 233 23 Drug transport 150 23 Drug transport, kinetic models 161 16 Duanomycin 91 17 Duazomycin A 324 22 Duphastone® (dihydrogesterone) 74 22 Durabolin® (nandrolone phenylpro-

pionate) 69 22 Durenat® (sulfamethoxydiazine) 31 22 Dydrogesterone (Duphaston®) 74 17 Dymanthine (Thelmesan®) 131, 151, 158,

162, 175 19 - 103 22 DymelorGP (acetohexamide) 81 20 Dyrenium® (triamterene) 417 19 Dysphagia 199,218

E

251

16 EAE (experimental allergic encephalomye-litis) 87

20 Ecarazine 205 18 Echenostoma ilocanum 196 20 Echinococcus 448 17 Echinococcus granulosus 149,293,303,306 18 Echinococcus infection 193 17 Echinococcus multilocularis 149,295,305 20 Ecolid® (chlorisondamine chloride) 409

252

22 Econazole 109, 119 17 Ectoral® (ronnel) 128 20 Edecrin® (ethacrynic acid) 417 23 Egg-white 37 17 11, 14-Eicosadienoic acid 437 17 Eicosa-5,8, 11, 14, 17-pentaenoic acid 430 17 5,8,11, 14-Eicosatetraenoic acid 433 17 5-cis-8-cis-12-trans-l4-cis-Eicosatetraenoic

acid 433 17 Eicosa-8,1l,I4-trienoic acid 431,434 17 8-cis-12-trans-l4-cis-Eicosatrienoic

acid 433 16 Eiweiss, gruppenspezifisches 374 20 Elavil® (amitriptyline) 394 16 Electrical stirn ulation 214 22 Electroencephalogram 358 19 Electrolyte loss 530 23 Electronic parameters 206 17 Electrophoresis 81 16 Electroshock 349 16 Elektrophoresemethoden 327 18 Elephantiasis 178, 260, 270 23 Elephantin 80 22 Elipten® (aminoglutethimide) 77 17 Emetine 113, 133, 134, 150 18 Emetine 86, 325, 355, 360 20 Emetine 439,451 17 17(- )-Emetine 24 17 Emeto-Na® (antimony sodium tar-

trate) III 20 Emivan® (etamivan) 397 16 Endocarditis 323 19 Endogenous pyrogen 403 22 p-Endorphin 199 23 Endorphins 60 16 Endotoxin 111,128 19 Endotoxin 402,471 19 Endotoxin fever 408 17 Endoxan® (cyclophosphamide) 305 22 Endoxan® (cyclophosphamide) 64 19 Energy metabolism 151 20 Enkephalin 95,334 22 Enkephalin 198 23 Enkephaline 60 16 Enolase 392,394 18 Entamoeba dispar 225 18 Entamoeba hartmanni 78 17 Entamoeba histolytica 150, 263 18 Entamoeba histolytica 78,225, 354 20 Entamoeba histolytica 438 18 Entamoeba polecki 78 16 Enterobius vermicularis 165 17 Enterobius vermicularis 172 18 Enterobius vermicularis 191 19 Enterobius vermicularis 21,29,48 20 Enterobius vermicularis 452 19 Enterotoxin 471,473 23 Enterotoxin 13 22 Entobex® (phanquinone) 42 20 Envacar® (guanoxane) 410 16 Enzymatic systems 344

Index Vol. 16-23

16 Enzyme 287,310,365 17 Enzyme 19 20 Enzyme 13 20 Enzyme induction 298 17 Enzyme inhibition 26 20 Enzyme inhibitors 13 23 Enzyme inhibitors 60 16 Enzyme, kiiltesensitive 367 16 Enzyme,oligomere 366 17 Enterobiasis 171 18 Enterobiasis 202 19 Enterobiasis 21 20 Enterobiasis 452 20 Eosinophiles 576 19 Ephedrine 521 20 Ephedrine 418,419 22 Epidemiological pharmacology 11 16 Epilepsy 212 17 Epinephrine 46 20 Epinephrine 200 21 Epinephrine 420 22 Epipolythiodiketopiperazines 309 17 Epitetracycline 213 17 trans-( - )-14, 15-Epoxygeranylgeraniol 274 16 cis-d,l-9, IO-Epoxyhexadecanoic acid 290 16 trans-d,l-9, IO-Epoxyoctadecanoic acid 290 20 Equanil® (meprobamate) 392 23 Equilibrium concentrations 102 22 Equilin sulfate 71 22 Equimate® (fluprostenol) 84 20 Eraldin® (practolol) 411 18 Ergometrine 414 21 Ergonovine maleate 374 22 Erimin® (nimetazepam) 262 23 Erythema 30 20 Erythroblastosis fetalis 584 16 Erythrocruorin 382,432 17 Erythrocyte 60 17 meso-Erythrol 71 16 Erythromycin 313,318 21 Erythromycin 175 22 Erythromycin 58 18 Erythromycin B 419 22 Erythromycin estolate 58 22 Erythromycin stearate 58 18 Erythronolide B 419 17 Erythronolide B boronyl esters 273 20 Esbatal® (betanidine) 410 16 Escherichia coli 51 18 Escherichia coli 22 19 Escherichia coli 460, 546, 574 21 Escherichia coli 167 23 Escherichia coli 61, 218 23 Escherichia coli 218 19 Escherichia coli infections 570 16 Eserine 217 19 Eserine 149 22 Estazolam (Eurodin®) 255 20 Estradiol 475 22 Estradiol 68 22 Estradiol benzoate 71

Index Vol. 16-23

17 Estradiol-17P 24 22 Estrone 71 20 Etamivan (Emivan®) 397 17 Ethacrynic acid (Edecrin®) 66 . 20 Ethacrynic acid (Edecrin®) 212,417 18 Ethambutol (Myambutol®) 212 22 - 36 17 Ethanol 16 20 Ethchlorvynol (Placidyl®) 387 17 Ether 94 16 Ethidium® bromide (homidum bro-

mide) 99 22 - 38 22 - 38 20 Ethinamate (Valmid®) 387 21 Ethinyloestradiol 300,318 22 Ethinylestradiol 71 18 Ethionamide (Trecator-SC®) 212 22 Ethionamide (Trecator-SC®) 36 22 Ethisterone (Amenorone®) 73 17 p-Ethoxyacetanilide 490 17 2-EthylaminoethyI2,2-diphenylvalerate

HBr (SKF 8742-A) 24 16 Ethylbenzene 261 16 6-Ethyldecanoic acid 239 22 5-Ethyl-deoxyuridine 297 17 Ethylenediaminetetraacetic acid 496 19 Ethylenediaminetetraacetic acid 284 21 Ethylene dimethane sulphonate (EDS) 351 17 Ethylene-l,2-dimethanesulphonate 274 17 Ethylene glycol 71 21 Ethylene glycol dimethyl ether 189 22 Ethylestrenol (Maxibolin®, Orabolin®) 70 16 3-Ethylheptanoic acid 238 21 13-Ethyl-17-hydroxy-18,19-dinor-17d­

pregn-4,9,II-trien-20-yn-3-one (R2323) 308, 322, 350

17 Ethyl isocyanide 12 17 N-Ethylmaleimide 73 21 N-Ethylmaleimide 183 17 Ethylmorphine 23,24 17 3-Ethyl-l-(5-nitro-2-thiazolyl)hydan­

toin 262 17 3-Ethyl-l-(5-nitro-2-thiazolyl)hydroura-

cil 262 16 2-Ethyloctadecanoic acid 236 16 4-Ethyloctanoic acid 239 16 2-[Ethyl-n-propylaminoJethyl-a,a-diphe-

nylglycolate HCl) (BRL 1288) 342 18 Ethyl stibamine (Neostibosan®) 310, 312 20 - 442 16 2-Ethyltetradecanoic acid 236 20 Ethyl urethan 387 18 Ethynodiol diacetate (Femulen®) 449 21 - 308 22 - 74 20 Etophamide 438,441 20 Etorphine 88 22 Etorphine 156 17 Etreno!® (hycanthone) 116

22 Etrenol® (hycanthone) 47 17 Eubothrium crassum 293 20 Eudismic affinity 105 20 Eudismic-aftinity correlations 136 20 Eudismic-aftinity quotient 105 20 Eudismic index 105 20 Eudismic relations 133 22 Euglucon® (glibenclamide) 81 23 Eupacunin 78 23 Euparotin 78 23 Eupaserrin 78 23 Eupatocunin 78 23 Eupatorin 83 22 Eurodin® (estazolam) 255

253

22 Eusaprim® (sulfamethoxazole + thrimetho-prim) 33

20 Eutomer 105 23 Exotoxin 13 16 Experimental allergic encephalomyelitis

(EAE) 87 22 Experimental pharmacology 11 21 Extrapyramidal syndrome 412 20 Eyes infection 361

F 16 F-3OO66 (furapromidium; N-isopropyl-5-

nitro-furanacrylamide) 60 17 - 266 20 Fabahistin® (mebhydroline) 426 19 Facial muscles 445 19 Facial weakness 446 18 Falciparum malaria 155 21 Family planning programs 296 20 Fanasil® (sulfadoxine, sulformethox-

ine) 436 22 - 31 17 Fasciola hapatica 134,270 20 Fasciola hapatica 451 17 Fasciola gigantica 134, 277 17 Fascioliasis 133, 276 20 Fascioliasis 451 17 Fasciolin® (hexachloroethane) 116 17 Fasciolopsiasis 137 20 Fasciolopsiasis 451 18 Fasciolopsis 194 17 Fasciolopsis buski 137,277 19 Fasciolopsis huski 137 20 Fasciolopsis huski 451 22 Fasigyne® (tinidazole) 46 16 w-Fatty acid-oxygenase 246 16 Fatty acids 233,239 16 Fatty acids, a-substituted 236 16 Fatty acids, P-substituted 238 16 FDA (Food and Drug Administration) 196 16 FDA Papers 208 16 FDC Reports 208 16 Federal Food, Drug and Cosmetic Act

(FDC Act) 207 16 Federal Register 208 16 Federal Regulations 207

254

20 Federal Trade Commission (FTC) 161 17 Fe(II)-ethylenediaminetetraacetic acid-

complex 490 21 Female reproduction 297 22 Femulen® (ethynodiol diacetate) 74 17 Fenchlorphos (ronnel) 128 20 Fenetylline (Captagon®) 396 20 Fenfluramine (Ponderal®) 419 22 - 363 20 Fenostil® (dimethindene) 426 20 Fentanyl (Leptanal®, Sublimaze®) 398,

399 22 - 185,211 16 Fenthion (Baytex®, Talodex®, Tigu-

von®) 168 17 - 128, 167, 182 16 Fermentation 272 17 Fermentation 229 23 Fermentation broths 55 23 Fermentation programs 55 16 Ferredoxin 430 19 Ferric ammonium citrate 546 17 Fertility control 458 23 Fertility control 56 17 Fertility, male 459 16 Fettsliure-Synthetase-Komp1ex 420 19 Fever pathogenesis 402 18 FI-345 (1-(3,4-dichlorcphenyl)-3-(4-{3-

[( diethylamino )methyl]-p-anisidino )-6-( tri­fluoromethyl)-2-pyrimidinyl)guani-dine) 150

16 Fibrinogen 380 16 Fibroin 380 17 Fibrosis 39 19 Filaria brugia 58 18 Filaria control 270 18 Filarial infection 178 19 Filarial infection, immunodiagnosis 128 17 Filariasis 180 18 Filariasis 45,174,201,260,270,284 19 Filariasis 128 20 Filariasis 455 18 Filariasis, control of 179, 188,265 18 Filariasis, distribution of 174 17 Filipin 67 18 Filipin 418 22 Filipin 95 19 Filter membranes 467 17 Flagyl® (metronidazole) 125 20 Flagyl@ (metronidazole) 438,439 22 Flagyl@ (metronidazole) 46 19 Flaxedil@ (gallamine) 296 20 Flaxedil@ (gallamine) 422 22 Fletazepam 249 22 Filixic acid 46 22 Florenal 303 22 Floxymesterone (Halotestin@, Ultan­

dren@) 69 18 Fluanisone 437 20 Flucytosine (5-Fluorocytosine, Anco­

bon@) 444

Index Vol. 16-23

22 - 36, 120, 132 22 Fludanaline (3-fluoro-D-alanine) 55 17 Flufenamate 470 17 Flufenamic acid 75 17 Flukanide@ (rafoxanide) 115,282 21 Flumequine 34 22 Flumethasone 17-trimethyl acetate (Loca-

corten@) 74 22 Flunitrazepam (Rohypnol@) 262, 360 22 Fluocinolone acetonide (Synalar@) 75 22 Fluocortolone 21-capronate (Ultralan@) 74 21 Fluoroacetamide 353 22 3-Fluoro-D-alanine (fludalanine) 55 17 5-Fluorocytosine (flucytosine) 331 22 5-Fluorocytosine (flucytosine) 444 16 5-Fluorodeoxyuridine 123 17 1-Fluoro-2,4-dinitrobenzene 73 17 5-Fluoroorotic acid 332 18 Fluoropipamide 437 17 5-Fluoropyrimidin-2(1H)-one 332 17 5-Fluoropyrimidin-4( IH)-one 332 21 Fluorouracil 174, 199 22 Fluorouracil 64,297 16 5-Fluorouracil 96, 123 17 5-Fluorouracil 329 20 5-Fluorouracil 469 17 5-Fluorouridine 329 17 5-Fluorouridylic acid 329 21 a-Flupenthixol 417 18 Fluphenazine (Prolixin@) 455 20 - 389 21 - 416,417 22 Fluprednylidene acetate (Decoderm@) 75 21 Fluprostenol (Equimate@) 326 22 - 84 22 Flurazepam (Daimane@) 261,361 20 Fluspirilene (Imap®) 391 16 Folic acid 93 17 Folic acid 324 18 Folic acid 107 19 Folic acid 108 20 Folic acid 471 22 Folic acid 86 17 Folic acid antagonists 324 16 Folinic acid 93 16 Follikelstimulierendes Hormon 374 16 Food and Drug Administration (FDA) 196 20 Food and Drug Administration (FDA) 18,

161, 164, 187, 193 21 Food and Drug Administration (FDA) 304 22 Formaldehyde 29 22 Formo-Cibazol@ (formosulfathiazole) 31 22 Formosulfathiazole (Formo-Cibazol@) 31 17 Formycin B 343 16 Formyl-Tetrahydrofolat-Synthetase 408 20 Fortral® (pentazocine) 398, 399 22 Fortral@ (pentazocjne) 160 22 Fosazepam 367 23 Fosfomycin 54 17 Frantin® (bephenium pamoate) 158 23 Free-Wilson analysis 202

Index Vol. 16-23

23 Free-Wilson model 101,202 23 - 202 17 Freon BU 277 17 Freon 112 277 23 Fructose 28 16 Fruktose-Diphosphatase 396, 398 17 Fuadin® (stibophen) 112 22 Fuadin® (stibophen) 47 21 Fucidin 175 22 Fulvicin® (griseofulvin) 55 16 Fumarase 404 22 Fungizone® (amphotericin B) 59 20 Furacin® (nitrofural, nitrofurazone) 446 22 Furacin® (nitrofural, nitrofurazone) 33 22 Furadantin® (nitrofurantoin) 33 22 Furaltadone (Altafur®) 45 20 Furarnide® (diloxanide fuorate) 438 16 Furapromidium (F-30066; N-isopropyl-5-

nitro-2-furanacrylarnide) 60 17 - 266 21 Furo[2,3-b)pyridines 91 17 Furosemide (Lasix®) 67 20 - 210,417 20 Fusaric acid 240 20 Fusarium oxysporum 241 16 Fusidic acid 314,318 22 Fusidic acid 59

G 17 G-61O (4-chloro-a,a'-bis(5-chloro-2-

hydroxyphenyl)-2,6-xylenol) 295 23 Galactose 33,41 23 o-Galactose 40 20 p-Galactosidase 328 16 Galaktose-l-Phosphat-Uridyl-Trans-

ferase 392 16 p-Galaktosidase 416,442 20 Gallamine (Flaxedil®) 422 23 Gambogic acid 71 16 Ganglia, basal 335 20 Ganglionic blockers 200 22 Gantanol® (sulfamethoxazole) 31 22 Gantrisin® (sulfisoxazole) 31 22 Garamycin® (gentamycin) 56 18 Gaschromatography 439 17 Gastric acid secretion, inhibitors of 460 17 Gastroenteritis 164 19 Gastroenteritis 490,519,572,578,586 19 Gastroenteritis, clinical evaluation 492 19 Gastroenteritis, diagnosis 594 19 Gastroenteritis, epidemiology 494,573 19 Gastroenteritis, features 574 19 Gastroenteritis, incidence 573,595 19 Gastroenteritis, investigations 572 19 Gastroenteritis, treatment 576 16 Gehirnprotein 374 17 Gel filtration 81 18 Gentamicin C I 423 18 Gentamicin CIa 423 18 Gentamicin C2 423

22 Gentamycin (Garamycin®) 56 16 Gentisic acid 98 22 Geopen® (carbenicillin) 51 16 Geranic acid 242 16 Gerinnungsfaktor VIII 432 16 Gerinnungsfaktor XIII 430 17 Germanin® (suramin sodium) 132 22 Germanin® (suramin sodium) 38 22 Gestafortin® (chlormadinone acetate) 74 19 Giardia lamblia 81 20 Giardia lamblia 441 20 Giardiasis 441 18 Gibberella/ujikuroi 323 17 Gibbs-Donnan equilibrium 62 22 Glibenclamide (Daonil®, Euglucon®) 81 22 Gli1lumide 80 22 Gliotoxin 309 22 Glisoxepide (Pro Diaban®) 80 22 Glitisol® (thiamphenicol) 54 22 Globucid® (sulfaethidole) 34 16 a 2-Globulin 108 16 )I-Globulin (immunoglobulin G) 378 20 Glomerulonephritis 584 20 Glucagon receptor 340 23 a-l,6-Glucan 29 20 Glucanthine® (N-methylglucamine anti-

moniate) 442 16 Glucokinase 436 22 Glucophage® (metformin) 80 22 o-Glucosamine 307 17 Glucose 70 23 Glucose 28,41 20 Glucose infusion 553 17 Glucose metabolism 62 20 Glucose metabolism 537 16 Glucose-6-phosphat-Dehydrogenase 410,

438 20 Glucose transport permease 329 23 o-Glucose 40 17 Glucuronic acid 488, 497 20 Glucuronic acid 563 20 a-Glucuronic acid lactone 563 18 Glucuronidase 18 16 p-Glucuronidase 440 20 p-Glucuronidase 559 16 Glutamat-Decarboxylase 412 16 Glutamat-Dehydrogenase 414 16 Glutamat-Mutase 402 16 Glutamic acid 221 16 Glutamic acid hydrazide 223 16 Glutamin-Aminotransferase 436 17 Glutamine antagonists 323 16 Glutaminphosphoribosyl-pyrophosphat-

Aminotransferase 406 16 Glutamin-Synthetase 416 22 Glutamyl guanidine 308 22 Glutaraldehyde 130 16 Glutathion-Peroxidase 392 16 Glutathion-Reductase 398 17 Glutethimide (Doriden®) 25

255

256

20 Glutethimide (DoridenGl) 387 22 - 366 23 DL-Glyceraldehyde 40 16 d-Glycerat-Dehydrogenase 390 16 Glycerinaldehyd-3-phosphat-Dehydroge-

nase 400, 436 16 Glycerin-Dehydrase 406 16 Glycerin-Kinase 408 16 Glycerin-3-phosphat-Dehydrogenase 390,

434 17 Glycerol 71 17 Glycero-phospholipid 77 16 Glycinase 328 20 Glycine receptors 341 16 Glycinin 432 16 Glycobiarsol (BroxolinGl, MilibisGl,

ViaseptGl) 173 17 - 123, 174 16 Glycogen-Phosphorylase 440 16 Glycolic acid 277 16 Glycolipids 264 17 Glycolipids 72 16 3-Glycoloyl-6-methyl-2,3-dihydropyran-

2,4-dione 261 17 Glycolysis 66 16 Glycopeptide 327 20 Glycoprotein 328 23 Glycoprotein extract 15 16 a 2-Glycoprotein 105 16 Glycosylation 297 16 Glycyl-tRNA-Synthetase 408 16 Glykogen-Phosphorylase A 414 16 Glykogen-Phosphorylase B 414 16 Glykogen-Synthetase 414 16 Glykolsiiure-Oxidase 412 16 Glykoprotein 374 20 Glycopyrrolate (Robinul®) 420 22 Glymidine (Redul®) 81 16 Glyoxylat-Carboligase 408 16 Glyoxylsiiure-Reductase 394 22 Glyprothiazol 80 20 cyclic-GMP (guanosine 3',5'-mono-

phosphate) 329,580 17 Gold chloride 70 23 Gonococcal vaccine 20 19 Gonorrh(o)ea 281 23 Gonorrhoea 20 16 Graft-versus-host (GVH) 89 17 Gramicidin 67 17 Gramicidin S 68 22 Griseofulvin (Fulvicin4!» 55, 122 18 Griseofulvins 415 20 Guaiphenesin (Resyl®) 392 19 Growth hormone 267 22 Growth hormone 360 19 Growth test 467 20 Guanabenz 216 20 Guanacline 215 20 Guancydine 216,240 20 Guanadrel 216

Index Vol. 16-23

17 Guaneran 341 20 Guanethidine (Ismelin4!» 214,410 21 - 357 16 Guanidin 366 22 Guanidines 79, 299 16 Guanidinoacetat-Kinase 394 20 Guanoclor (Vatensol4!» 215,410 20 Guanoctine 240 20 Guanosine 3',5'-monophosphate (cyclic

GMP) 329 20 Guanoxane (Envacar4!» 215,410 20 Guanylate cyclase 329 18 cis, trans, cis-tetrakis-(4-Guanylphenyl)

cyclobutane 317 16 Gurkenmosaik-Virus 382 21 Guthion 190 16 GVH (Graft-versus-host) 89

H 16 HA-966 (l-hydroxy-3-amino-pyrrolid-

one-2) 348 22 Hachimycin 107 19 Haemagglutination Test 77,123,131,268 17 Haemoglobin 62, 92 17 Haemolysis 75,92 17 Haemolysis, reversibility 94 16 Haemonchus contortus 161, 163 17 Haemonchus contortus 164 20 Haemonchus contortus 350 18 Haemorrhage 81 22 Haldrone4!> (paramethasone acetate) 75 22 Haliconllll (triazolam) 254,255 16 Hallucinogenic action 224 16 Haloperidol (Serenace4!» 342,346 17 - 25 18 - 437 20 - 390 21 - 414 22 Haloprogin (Halotex®) 29, 127 22 Halotestinllll (floxymesterone) 69 22 Halotex4!> (haloprogin) 29 17 Halothane (1,1, I-trifluoro-2-chloro-2-bro­

moethane) 16,76 16 Haloxon (Helmiron®, Loxon®) 158,168 17 - 129,158,160,164,168,170,

173, 175 16 Hiimagglutinin 376,380,382 16 Hiimerythrin 376 23 Hammett constant 101,206 16 Hiimocyanin 382,432 16 Hiimoglobin 382,376,432 16 Hiimoproteide 367 22 Hamycin 106 23 Hansch model 101 18 Hansolar® (acedapson), 4',4"'-sulfonyl-

bisacetanilide) 108, 156 16 Haptoglobin 1-1 376 16 Harmaline 353 16 Harmine 353 20 Harmonyl® (deserpidine) 408

Index Vol. 16-23

16 Hamstoff 366 16 Health, Education and Welfare

(HEW) 207 20 Health statistics 499 20 Heart diseases 506 17 Heart diseases, hypertensive 39 17 Heart diseases, rheumatic 39 17 Heart muscle 39 16 Hefe-Enolase 370 16 Hefe-Hexokinase 370 16 Hefe-Phosphofruktokinase 370 22 Helenine 272 17 Helmatac® (perbendazole) 159 22 Helmatac® (perbendazole) 49 17 Helmetina® (phenothiazine) 131 19 Helminthiasis 11,48 19 Helminthiasis, chemotherapy of 158, 162 19 Helminthiasis, intestinal 158 19 Helminth infections 119, 155, 160 19 Helminth physiology 147 17 Helmiron® (haloxon) 129 18 Hemagglutinin 255 17 Hemoglobin 492 17 Hepadist® (hexachlorophene) 114 23 Heparin 43 19 Hepatitis 281 17 Heptachlor epoxide 24 16 Heptane-l,7-dioic acid 235 19 Herd immunity 252 22 Heroin 151 17 Heterophyiasis 138 18 Heterophyes heterophyes 196 17 Hetol® (hexachloroparaxylol) 117,270 20 Hetol® (hexachloroparaxylol) 450 17 Hetolin (l-methyl-4-[3,3,3-tris(p-chloro­

phenyl)propionyl]piperazine hydrochlo­ride, Dicroden®) 118, 133, 287

17 Hetrazan® (diethylcarbamazine) 127 20 Hetrazan® (diethylcarbamazine) 455 22 Hetrazan® (diethylcarbamazine) 48 16 HEW (Health, Education and Wel-

fare) 207 18 1,2,3,4,5,6-Hexachlorocyclohexane

(BHC) 248, 267 17 Hexachloroethane (carbon hexachloride,

Fasciolin®) 116, 132, 136, 139, 277 17 3,3',5,5', 6,6'-Hexachloro-2'-hydroxysali­

cylanilide 283 17 Hexachloroparaxylol (a,a,a,a',a',a'-hexa­

chloro-p-xylene, Bitriben®, Chloxyle®, Hetol®) 117, 132, 133, 136-138,270,277

20 - 450 17 Hexachlorophene (hexachlorophane, Bile­

von®, Hepadist®, Hexosan®, pHiso-hex®) 114,135,153,278,295

22 - 29, 128 16 Hexadecanoic acid 244 16 [lo-'4]-cis-Hexadec-9-enoic acid 288 16 2,4-Hexadienoic acid 240 16 2,4-Hexadienoic acid amide 241,246 16 2,4-Hexadienoic acid methylamide 241

17 2,3,4,4a,5,6-Hexahydro-IH-pyrazino­[1,2-a]quinolines 254

23 2,3,4,4a,5,6-Hexahydro-IH-pyrazino­[1,2-a]quinolines 217

16 Hexamethonium chloride (Vegoly-sen®) 219

20 - 200,409 17 Hexamethylmelamine 362 20 Hexamethylmelamine 476 17 Hexamethylphosphoramide 274 22 Hexetidine 130 17 Hexobarbital 23,490 16 Hexokinase 396 16 Hexosaminidase 328 22 Hexosan® (hexachlorophene) 29 16 n-Hexylphenylketone 262 19 Hexylresorcinol (Caprokol®) 36 22 - 46 16 Hildebrandt acid 242 17 Hilomid 114, 135, 139,282 16 Hippocampus 212 16 Hippuric acid 260,261 22 pHisohex® (hexachlorophene) 29 20 Hispril® (diphenylpyraline) 424 20 Histamine 414 23 Histamine 31,39,43 16 Histidin-Ammonium-Lyase 406 16 Histidin-Decarboxylase 404 16 Histidinol-Dehydrogenase 392 16 Histidinolphosphat 388 17 HN2 (nitrogen mustard, mechloreth-

amine) 349 17 nor-HN2 353 20 Homatropine 420 16 Homidium bromide (Ethidium®) 99 22 - 38 22 Homobenzomorphans 165 22 4-Homo-isotwistane 279 17 Homomycin 302 17 w-Homo-prostanoic acid 420 16 Homoserin-Dehydrogenase 400 16 Homovanillic acid 336 21 Homovanillic acid 414 17 Hookworm 160 18 Hookworm 45, 280 19 Hookworm 40,81 20 Hookworm 355 19 Hookworm anaemia 108 19 Hookworm disease 6,36,44,81,86 19 Hookworm infection 2, 17,23,64,70,90,

99, 108, 170 20 Hookworm infection 453 20 Hormones 475 23 Hormones 51 21 Hospital monitoring 245 16 HSA (human serum albumin) 108 16 Hiillprotein 376 21 Human chorionic gonadotrophin 359 21 Human chorionic sommatomammotro-

phin 365 16 Human serum albumin (HSA) 108

257

258

17 Humatin® (paromomycin) 122 20 Humatin® (paromomycin) 447 16 Humoral immunity 73 22 Hyalodendrin A 310 21 Hyaluronidase 366 16 Hycanthone (Etrenol®) 32,33,35,36,37,

47,49 17 - 116,142,144,147,245,246 18 - 16 20 - 448 22 - 47 18 Hycanthone, clinical results 19 16 Hycanthone acid 32 16 Hycanthone aldehyde 32,35 16 Hycanthone methanesulfonate 49 16 Hycanthone sulfoxide 36 22 Hydantoin derivatives 287 19 Hydatid disease 75 20 Hydatid disease 448 20 Hydergin® 415 20 Hydracarbazine 409 17 Hydracrylic acid 353 20 Hydralazine (Apresoline®) 203, 204, 205,

408 16 a-Hydrazinohistidine 99 18 Hydrocele 260,270 20 Hydrochlorothiazide 210 17 Hydrocortisone 24, 25 16 Hydrogenase 388,434 17 15-Hydroperoxy-8, II, 13-eicosatrienoic

acid 435 23 Hydrophilicity 136 23 Hydrophobic interaction 99 23 Hydrophobic parameters 205 17 o-Hydroxyacetanilide 497 17 p-Hydroxyacetanilide 490,497 16 w-Hydroxyacetophenone 261 16 Hydroxy acid dehydrogenase 245,247 17 N-Hydroxyadenine 346 16 I-Hydroxy-3-amino-pyrrolidone-2 (HA-

966) 348 18 IIP-Hydroxy-androstenedione 430 22 14-Hydroxyazidomorphine 156 16 y-Hydroxybutyric acid 348 21 y-Hydroxybutyric acid 411 17 3-Hydroxycoumarin 494 17 4-Hydroxycoumarin 494 17 5-Hydroxycoumarin 495 17 6-Hydroxycoumarin 494 17 7-Hydroxycoumarin (umbelliferone) 494 17 8-Hydroxycoumarin 494 17 N-Hydroxycyc1ophosphamide 358 17 4-Hydroxycyclophosphamid 357 20 4-Hydroxycyclophosphamid 468 17 3-D-Hydroxydecanoic acid 437 16 IO-Hydroxydecanoic acid 306 16 p-H ydroxydecanoyl-Thioester-Dehy­

drase 434 17 7a-Hydroxy-5,II-dioxo-tetranor-prosta-

1, 16-dioic acid 452

Index Vol. 16-23

17 7a-Hydroxy-5,II-dioxo-tetranor-prosta­noic acid 452

21 6-Hydroxydopamine 412 17 II-Hydroxy-12-trans,l4-cis-eicosadienoic

acid 437 17 II-Hydroxy-8, 12, 14-eicosatrienoic

acid 439 17 15-Hydroxy-8, 11, 13-eicosatrienoic

acid 435, 439 17 4-[(2-Hydroxyethyl)amino ]-2-(5-nitro-2-

thienyl)quinazoline 308 17 N-(2-Hydroxyethyl)-N'-(3-hydroxy­

propyl)ethylenediamine 352 17 12-H ydroxy-8-trans, lO-trans-heptadeca­

dienoic acid 439 16 d-2-Hydroxyhexadecanoic acid, biosynthe-

sis of 280 16 5-Hydroxyindolacetic acid 340 16 Hydroxyindol-O-Methyltransferase 390 17 4-(2-Hydroxy-3-isopropylaminopropoxy)-

acetanilide (l.e.1. 50172) 53 17 Hydroxylase 14 17 Hydroxylation, aromatic 12 17 Hydroxylation, enzymatic 490 16 w-l-Hydroxylation 246 16 5-Hydroxylysine 296 17 5-[( 4-Hydroxy-3-methoxy)benzylidene ]-2-

imino-l-methyl-4-imidazolidinone 291 20 I4-Hydroxymorphine derivatives 56 16 1-6-Hydroxynicotin-Oxidase 394 20 I4-Hydroxynorrnophinone 57 16 2-Hydroxyoctadecanoic acid 281,289 16 [12, 13-3H]-9-d-Hydroxyoctadecanoic

acid 289 17 o-Hydroxy-phenylacetic acid 493 17 o-Hydroxy-phenyllactic acid 493 17 o-Hydroxy-phenylpyruvic acid 493 17 5-Hydroxypicolinaldehyde thiosemicarba­

zones 347 17 17-Hydroxyprogesterone 499 22 Hydroxyprogesterone caproate (Delalu-

tin®) 73 17 Hydroxyproline 491 16 l-trans-4-Hydroxyproline 296 17 15-Hydroxy-prostaglandin dehydroge-

nase 447 17 19-Hydroxyprostaglandin AI 450,451 17 20-Hydroxyprostaglandin AI 450 17 19-Hydroxyprostaglandin BI 451 17 19-Hydroxyprostaglandin B2 451 17 I5-Hydroxyprostaglandin dehydrogenase

substrate, specificity of 448 23 4-Hydroxyquinoline-3-carboxylates 139 17 Hydroxystilbamidine 377 18 Hydroxystilbamidine 319 22 Hydroxystilbamidine 125 16 2-Hydroxy tetracosanoic acid 282 17 5-Hydroxytetracycline 217,227 22 4' -Hydroxy-5,6, 7,8-tetramethoxyfla­

vone 304

Index Vol. 16-23

16 Hydroxytryptamin (5-HT, serotonin) 221, 336,341

19 5-Hydroxytryptamin (5-HT, serotonin) 149 20 5-Hydroxytryptamin (5-HT, serotonin) 426 23 5-Hydroxytryptamin (5-HT, serotonin) 31,

39,43 16 5-Hydroxy-tryptophan 220,340 17 Hydroxyurea 348 20 Hydroxyurea 473 21 Hydroxyurea 199 20 Hydroxyzine (Atarax®) 392 20 Hygroton® (chlorthalidone) 417 17 Hymenolepiasis 150 19 Hymenolepiasis 13,55 17 Hymenolepis carioca 294,301 17 Hymenolepis diminuta 298,302 18 Hymenolepis diminuta 198 19 Hymenolepisfratema 55 17 Hymenolepis nana 150,292,294 18 Hymenolepis nana 191 19 Hymenolepis nana 13,81, 106 20 Hymenolepis nana 447 17 Hyostrongyliasis 163 17 Hyostrongylus rubidus 163 23 Hyperglycaemia 37 19 Hypersensitivity fever 407 17 Hypertension 464 20 Hypertension 37, 198 21 Hypertension 317 20 Hyperthermia 552 20 Hypnotics 386 19 Hypoalbuminaemia 110 22 Hypochlorite 28, 29 19 Hypoferremia 551 16 Hypoglycemia 341 19 Hypoglycemia 530 23 Hypoglycemia 37 19 Hypophysis 306 16 Hypoprolinemia 343 18 Hypotension 394 19 Hypothalamus 306, 406 16 Hypothermia 342 21 Hypovitaminosis 314 16 Hypoxanthin-Guanin-Phosphoribosyl­

Transferase 434

I 20 Ibidomide 238 20 Ibuprofen (Brufen®, Motrin®) 402 18 ICI-3,349 (1-(p-chlorophenyl)-3-(4-{[2-(di­

ethylamino )ethyl]amino }-6-methyl-2-pyri­midinyl)guanidine) 132

17 I.C.I. 50172 [( 4-(2-hydroxy-3-isopropylami-nopropoxy)acetanilide)] 53

22 Idoxuridine (Stoxil®) 61 17 Ifosfamide 359 16 IgA (Immunoglobulin type A) 76 16 IgD (Immunoglobulin type D) 76 16 IgE (Immunoglobulin type E) 76 16 IgG (Immunoglobulin type G) 74,76, 102 16 IgM (Immunoglobulin type M) 76, 382

20 Ildamen® (oxyfedrin) 406 17 Ileum 460 20 Illnes, prognosis of 495 20 Imap® (fiuspirilene) 391 16 Imidazole 278 16 Imidazolylacetophosphat-Amino-Trans­

ferase 434 16 2-Imino-5-nitrothiazolinylacetic acid

derivatives 18 17 Imipramin (Tofranil®) 25 20 - 394 22 - 365 16 Immune process 72 16 Immune reactions 73 16 I=une system 70 23 Immunity indicators 17 19 Immunization 252,263,274,476 20 Immunization 574 23 Immunization 10, 56 19 Immunization progress 276 19 Immunization, response to 263 19 I=unization test 509 20 I=unochemical research 574 16 Immunogen 70 16 Immunogen reactive cells (IRC) 70 19 Immunoglobulin 552 20 I=unoglobulin 577, 579 16 Immunoglobulin A (IgA) 76 23 Immunoglobulin A (IgA) 17 16 Immunglobulin-A-Myelomprotein 378 16 Immunoglobulin D (IgD) 76 16 Immunoglobulin E (IgE) 76 20 Immunoglobulin E (IgE) 589 16 Immunoglobulin G (IgG) 74,76, 102 23 Immunoglobulin G (IgG) 18 16 Immunoglobulin M (IgM) 76, 382 23 Immunoglobulin M (IgM) 18 20 Immunoinfiammatory disease 583 19 Immunological mechanisms 155 19 Immunological research 282 16 Immunologic tolerance 77 20 Immunology 573 16 Immunosuppression 69,70,74,76 16 Immunosuppression, biological tests 80 16 Immunosuppressive activity 101 16 Immunosuppressive agents 71,82 20 I=unosuppressive agents 582, 583 16 Immunosuppressive therapy 74, 78 20 Immunosuppressive therapy 583 22 Imodium® 195 17 Imuran® (azathioprine) 341 23 Inaba vaccine 14 16 IND (Notice of Claimed Investigational

Exemption for a New Drug) 196 20 Indalitan® (clorindion) 404 20 Inderal® (propranolol) 36, 411 20 Indocid® (indomethacin) 402 17 Indomethacine (Indocid®) 75,433,470 19 - 526 20 - 402 20 Indoramin 242,415

259

260

20 Industrial drug research 16, 143 20 Infant mortality 500 18 Infection 278 19 Infection immunity 475 18 Influenza 253,281 23 Influenza 13 19 Influenza vaccine 276 23 Influenza vaccine 18 18 Influenza virus 253 18 Influenza virus, Hong Kong strain 253 21 Inhibin 378 22 Inorganic complexes 304 17 Inosine 63 20 Insect stings 589 20 Insidon® (opipramol) 394 22 Insomnia 367 16 Insulin 374 20 Insulin 327 22 Insulin 79, 82 23 Insulin 37,38 20 Insulin receptor 327 20 Insulin receptor interaction 329 20 Intal® (cromolyn sodium) 427 20 Intensain® (carbochromen) 407 22 Interferon 63,269 23 Interferon 60 19 Intestinal antibodies 565 19 Intestinal malabsorptiol1 108 21 Intrauterine devices 369 22 Invenol® (carbutamide) 80 20 Inversine® (mecamylamine) 409 16 Invertase 406 23 Invert sugar 28 18 Iodine 274 20 Iodochlorohydroxyquin 439 17 7-Iodo-6-demethyl-6-deoxytetracy-

cline 221 22 5-Iododeoxycytidine 296 22 5-Iodo-2'-deoxyuridine 295 20 Ionizing radiation 533 17 Ion permeability, passive 71 17 Ion regulation 62 17 Ion selectivity 64 17 Ion transport 71 17 Iprindole 25 16 Iproniazid (Marsilid®) 220 20 - 217,395 16 IRC (Immunogen reactive cells) 70 22 Irgasan DP300® (triclosan) 29 19 Iron 283 19 Iron deficiency 110 20 Irradiation 486 20 Ismelin® (guanethidine) 410 18 Isobutane 382 16 Isocitrat-Lyase 406 20 Isocyclorphan 60 17 Isoniazid (Neoteben®, Rirnifon®) 26 18 - 212 22 - 34 16 Isonicotinic acid hydrazide 224 17 Isonicotinic acid hydrazide 25

Index Vol. 16-23

16 1-Isopentenyl adenosine 95 20 Isophosphamide 480 20 Isoprenaline (Isuprel®) 28,411,419 22 Isoprinosine 297 17 4-(2-Isopropylamino-I-hydroxyethyl)­

methanesulfonanilide HCI (MJ 1999) 35, 53

17 2-[(lsopropylamino )methyl]-6-methyl-7-nitro-I,2,3,4-tetrahydroquinoline (UK 3883) 253

16 p-Isopropylmalat-Dehydrogenase 390 16 Isopropylmalat-Synthetase 400 20 Isopropylmethoxarnine 28 17 N -Isopropyl-5-nitro-2-furanacrylamide

(furapromidium, F-30066) 266 20 Isopropylphosphothionates 107 17 Isoprostane 423 17 Isoptin® (verapamil) 46 20 Isoptin® (veraparni1) 406 22 Isoquinazepon 250 17 I-Isoquinolinecarboxaldehyde thiosernicar-

bazone 347 20 Isospora belli 438 20 Isospora hominis 438 20 Isoterism II 17 Isothiocyanates 287, 300 17 Isothiocyanatodiphenylamines 30 I 17 2-(4-Isothiocyanatophenyl)benzimidazole

hydrochloride 272 17 2-( 4-Isothiocyanatophenyl)-5-chlobenz­

imidazole 288 17 2-[2-( 4-Isothiocyanatophenyl)ethyl]-5-

methoxybenzimidazole 288 17 4-(3-Isothiocyanatophenyl)thiazole 288 17 2-( 4-Isothiocyanatostyryl)benzimid­

azole 288 22 Isoxyl® (thiocarlide) 36 20 Isuprel® (isoprenalin) 419

J 23 Jatrophone 83 17 Jaundice 93 19 Jenner's vaccine 276 22 Jetrium® (dextromoramide) 189 17 Jonit® (bitoscanate) 131 19 Jonit® (bitoscanate) 64,90,91 22 Jonit® (bitoscanate) 49

K 22 Kafocin® (cephaloglycin) 53 20 Kala Azar (Visceral Leishmaniasis) 442 21 Kanamycin (Kantrex®) 131,176 22 Kanamycin (Kantrex®) 56 22 Kantrex® (kanamycin) 56 16 Kartoffelvirus X 384 16 Katalase 408 22 Keflex® (cephalexin) 53 22 Keflin® (cephalothin) 53 22 Kefzol® (cefazolin) 53 22 Kelfizina® (sulfalene) 31 22 Kenacort® (triamcinolone) 75

Index Vol. 16-23

22 Ketazolam 253 20 Ketocyclazocine 82 16 4-Ketocyclophosphamide 88 17 4-Ketocyclophosphamide 354,356 16 2-Keto-3-desoxy-phosphogluconat-Aldo-

lase 390 16 Ketoglutarat-Dehydrogenasekilmplex 420 16 [l-14C]-2-Ketooctadecanoic acid 284 20 Ketoprofen (OrudisS) 402 17 15-Keto prostaglandin reductase 450 16 a-Ketosiiure-Reductase 434 16 p-Keto-Thiolase 404 20 KetrexS (levamisole) 452 20 Khellin 427 17 Klebsiella pneumoniae 275 19 Klebsiella pneumoniae 546 16.Kohlensiiure-Anhydratase 404 16 Kreatin-Kinase 392 16 a-Kristallin 382

L 17 Labor, induction of 456 16 Lactat-Dehydrogenase 370,400 16 L-Lactat-Dehydrogenase 408 16 Lactat-Oxidase 410 17 Lactic acid 62 20 Lactic acid 548 19 Lactoferrin 552 16 p-Lactoglobulin 374 16 Lactose-Repressor 430 16 y-Laevulinsiiure-Dehydratase 410 18 Lagosin 418 20 LampitS (Bayer 2502; nifurtimox) 446 22 LampitS (Bayer 2502; nifurtimox) 45 22 LampitS (nifurtimox) 45 22 Lamprenes (clofazimine) 38 18 Lankamycin 420 20 Largactils (chlorpromazine) 389 20 Laroxyls (amitriptyline) 394 17 Larumens (drocarbil) 121 17 Larva migrans 184 18 Larva migrans 193 20 Larva migrans 455 20 Lasixs (furosemide) 417 16 Learning 216,355 16 Learning test 357 17 Lecithianase A 440 17 Lecithin 75, 78

·17 Lecithin-cholesterol-acyl transferase 77 22 LedercortS (triamcinolone) 75 22 LederkynS (sulfamethoxypyridazine) 31 21 Left ventricular ejection time (L VET) 107 21 Left ventricular injection time index

(LVE-TI) 115 18 Leishmania braziliensis 291,293 18 Leishmania chamaeleonis 298 18 Leishmania donovani 293 18 Leishmania enrietti 297 18 Leishmania mexicana 293 18 Leishmania tarentolae 298 18 Leishmania tropica 291,292

18 Leishmaniasis 290 19 Leishmaniasis 281 18 Leishmaniasis chemotherapy 301 20 Leponexs (clozapine) 391 18 Lepra cells 57 19 Leprospirosis 281 18 Leprosy 25,44,54,159,274 19 Leprosy 281,331 18 Leprosy epidemiology 25 18 Leprosy neuropathology 54, 72 18 Leprosy pathogenesis 58 20 Leptanals (fentanyl) 398, 399 22 Leptanals (fentanyl) 185 18 Leptospirosis 280 16 Leucinaminopeptidase 370,410,414 22 Leucine-enkephaline 198 23 Leuconostoc mesenteroides 30 16 Leucyl-tRNA-Synthetase 436 20 Leukemia 584 22 Leukerans (chlorambucil) 63 18 Leurosidine 413 18 Leurosine 414 20 Levallorphan 59,81 22 Levallorphan 166 16 Levamisole (KetrexS, LevasolS) 162 17 - 156,178,181 18 - 182,193,202 19 - 32,33 20 - 347,349,357,452,588 22 - 48,49,288 22 Levanxols (temazepam) 242,261 22 Levasols (levamisol) 48 22 Levorphanol (DromoranS) 166 23 - 117 22 Lexotanils (bromazepam) 250, 262 20 Libriums (chlordiazepoxide) 393 22 Libriums (chlordiazepoxide) 230,238 22 Lidaprims (sulfametrole + trimetho-

prim) 31 17 Lidocaine (XylocaineS) 50,51,75 20 - 403 17 Lilly 18947 (2,4-dichloro-6-phenyl­

phenoxyethyl-diethylamine HBr) 19

261

17 Lilly 32391 (DPEA, 2,4-dichloro-6-phenyl-phenoxyethylamine Hel) 19

22 Lincocins (lincomycin) 59 16 Lincomycin (LincocinS) 318 22 - 59 23' Lincomycin analogs 180 23 Linear free energy related model 204 17 Linoleic acids 433 20 Lioresals (baclofen) 423 17 Lipids 76 16 Lipoamid-Dehydrogenase 396 23 Lipophilicity 98, 213 23 Lipophilicity optimum 151 23 Lipopolysaccharides 14 16 p-Lipoprotein 432 16 Lipoprotein, high-density 378 17 Liposolubility 84 16 a-Lipovitellin 380

262

16 P-Lipovitellin 380 21 Lippes Loop 329 19 Listeria monocytogenes 546 18 Litomosoides carinii 143,261 19 Litomosoides carinii 128 18 Liver abscess 85, 234 20 Liver abscess 440 16 Liver microsomes 253, 259 17 Liver cell 488 19 Loa loa 128 20 Loa loa 457 20 Loaiasis 457 22 Locacorten® (flumethasone 17-trimethyl

acetate) 74 20 Local anaesthetics 403 23 Lochnericine 86 19 Lockjaw 219 16 Lombricin-Kinase 392 17 Lombristop® (thiabendazole) 125 22 Lomidine® (pentamidine) 45 22 Lomotil® (diphenoxylate) 195 22 Lomustine 64 20 Lopresor® (metoprolol) 411 22 Lorazepam (Ativan®) 242 23 Lorenz-Lorenz equation 207 22 Loridine® (cephaloridine) 53 22 Lotrimin® (clotrimazole) 36 17 Loxon® (haloxon) 129 17 Loxuran® (diethylcarbamazine) 127 16 Lucanthone (Miracil D®, Nilodin®, Tixan-

tone®) 24, 36 17 - 115,141,144,147,245 18 - 16 19 - 154 20 - 448 22 - 47 16 Lucanthone, metabolism of 29,36 16 Lucanthone sulfoxide 36 16 Luciferase 388,392,394 20 Ludiomil® (maprotilin) 394 20 Luminal® (phenobarbital) 387 18 Lung tuberculosis, chronic 217 17 Lungworm 178 18 Lungworm 195 20 Luteinizing hormone (LH) 285 21 Luteinizing hormone (LH) 302 16 Luteinisierungshormon 374 21 Luteolytic agents 325 20 Lymphocytes 577 23 Lymphocytes 38 16 Lymphoid atrophy 85 22 Lynestrenol (Orgametril®) 74 16 Lysin-2,3-Aminomutase 412 22 Lysodren® (mitotane) 77 17 Lysolecithin 78,81 20 Lysosomal cytolysis 551 20 Lysosomal enzymes 551 20 Lysosomal mechanisms 551 16 Lysostaphin 310,313,318 16 Lysostaphin biosynthesis 310 16 Lysotaphin immunology 326

Index Vol. 16-23

16 Lysostaphin resistance 325 16 Lysostaphin toxicology 327 16 Lysozyme resistance 325 16 Lysyl-tRNA-Synthetase 438 16 Lytic activity 318

M 16 a 2-Macroglobulin 432 20 Macrophages 577 22 Madar® (desmethyldiazepam) 262 22 Madribon® (sulfadimethoxine) 31 16 Magnesium 215 19 Magnesium deficiency 531 19 Magnesium sulphate 521 16 Magnesium pemoline 348 16 Major tranquilizers 91 16 Makromolekille 365 19 Malabsorption studies 110 18 Malaria 47,101,184,246,283 19 Malaria 281 20 Malaria 435 18 Malaria control programme 246 18 Malaria eradication 246 20 Malaria prophylaxis 437 16 Malat-Dehydrogenase 388,400,402,418,

434 23 Malate dehydrogenase inhibition 141 18 Malathion 249 21 Male contraception 378 21 Male reproduction 346 21 Malformations 242 19 Malic acid 286 20 Malignant tumours 508 19 Malnutrition 136,267 20 Management 184, 188 20 Mandelic acid nitrile glucuronide 566 23 Mannan 30, 33, 40 16 Mannitol 86 16 Mannomustine 86 23 Mannose 30,41 23 D-Mannose 40 18 Mansonia uniformis 179 18 Manzonella ozzardi 142,260 20 Maprotiline (Ludiomil®) 394 22 Marboran® (methisazone) 63 17 Maretin® (naphthalophos) 129 20 Marezine® (cyclizine) 426 21 Margulies spiral 329 16 Marihuana 224 22 Marijuana 365 20 Marsilid® (iproniazid) 395 16 Maskierung 367 19 Mass immunization 255,366 18 Mass spectrometry 400,401,408,439 20 Mast cells 576 23 Mast cells 43 19 Mastomys natalensis 58 19 Mastomys unguiculatus 58 22 Maxibolin® (ethylestrenol) 70 23 Maytansine 87 20 Mazindol (Sanorex®) 420

Index Vol. 16-23

19 M&B 938 (diamidino diphenylamine dihy-drochloride) 259

16 MeA (3-Methylcholanthrene) 98 18 Measles 28,241,281 19 Measles vaccine 279,347 16 Mebendazole (Telminill>, Vermoxill» 159,

160 17 - 126, 170-172 18 - 193,202 19 - 32,41,152,166 20 - 447,452 22 - 49 20 Mebhydroline (Fabahistinill» 426 20 Mecamylamine (Inversineill» 202, 409 17 Mechlorethamine (HN2, nitrogen mus-

tard) 349 17 Medofenamate 470 22 Medazepam (Nobriumill» 249,261 20 Medical practice 493 20 Medical practitioners 195 20 Medicinal chemistry 16, 144 20 Medicinal drugs 17 20 Medicinal research 10, 182, 511 23 Medicinal research 52 16 Medrolill> (methylprednisolone) 103 22 Medrolill> (methylprednisolone) 74 21 Medroxyprogesterone 320,348 16 Medroxyprogesterone acetate

(Proveraill» 92 21 - 308 22 - 73 20 Mefenamic acid (Ponstanill» 401 20 Mefioquine (WR 142.490) 437 22 Mefioquine (WR 142.490) 42 22 Mefoxinill> (cefoxitin) 53 22 Megace® (megestrol acetate) ;3 18 Megalomycin A 419 21 Megestrol acetate (Megaceill» 305 22 - 73 20 Megimideill> (bemegride) 397 18 Meglumine antimoniate 308 17 Melarsen® (melarsonyl potassium, trime-

larsen, Mel Will» 123, 179, 182 17 Melarsonyl potassium (Mel Will» 123 20 - 446 20 Melarsoprol (Mel Bill>, Arsobalill» 445 22-40 20 Mel Bill> (melarsoprol) 445 22 - 40 16 Melengestrol acetate (MGAiII» 92 20 - 586 21 - 335 20 Melitracen (Trausabunill» 394 20 Mellerilill> (thioridazine) 389 17 Melphalan (Alkeranill» 349 20 - 468 22 - 63 20 Melsedinill> (methoqualone) 389 17 Mel Will> (melarsonyl potassium) 123 20 - 446 20 Membrane drug receptor 323 19 Membrane filters 461,467

17 Membrane permeability 84 17 Membrane potentials 64 17 Membrane stabilization 75 17 Membrane structure 64,86 16 Memory 355 22 Menadione 86 17 Menichlopholan (Bayer 9015, Bilevon-

Mill» 278,281 18 Meningitis 281 23 Meningitis 18 23 Meningococcal meningitis 13 19 Meningococcus meningitis 280 20 Meningo-encephalitis 441 17 Mepacrine (quinacrine, Atebrinill» 294 22 - 38 20 Meperidine (pethidine, Dolantin®) 398 22 - 168 19 Mephenesin (Myanesin®) 290,297,362 20 - 392,422

263

19 Meprobamat (Equanilill» 210,225,289,297 20 - 392 23 Mepyramine 39 22 Merbromin (Mercurochrom lll) 29 22 Mercaptoalkylamines 276 19 2-Mercapto-ethanol 543 22 Mercaptopurine (Purinethollll) 64 16 6-Mercaptopurine 77,94, 103, 119 17 6-Mercaptopurine 336,339 20 6-Mercaptopurine 470, 473, 583 20 6-Mercaptopurine glucuronide 563 16 3-Mercaptopyruvatsulfurtransferase 388,

434 17 Mercuric chloride 70 22 Mercuric chloride 129 22 Mercurochrom (merbromin) 29 20 Mercurous chloride (calomel) 415 21 Mercury 124 22 Merfenill> 29 19 Meriones unguiculatus 58 16 Meromyosin 378 17 Mesocestoides lineatus ISS 22 Mesoridazine 357,368 22 Mesterolone (Pro-Vironlll) 69,70 21 Mestranol 299,348 22 Mestranol 71 20 Metabolic inhibitors 272 16 Metabolism 272 17 Metabolism 322 20 Metabolism 272 17 Metabolism inhibitors 65 17 Metabolism (oxidative) of drugs 488 20 Metabolite antagonist 12 20 Metabolites IS 20 Metalol 32 22 Metandrenlll (17a-methyltestosterone) 69 17 Metastrongylus apri 178 22 a-Metazocine 160 22 Metformin (Glucophagelll ) 80 17 Methacycline (6-demethyl-6-deoxy-5-

hydroxy-6-methylene-tetracycline) 211, 212,228,236

22 a-Methadol 193

264

20 Methadone (Polamidon®) 398 22 - 189 21 Methallibure 350 16 Methamphetamine 347 22 Methandienon (Dianabol®) 68 18 Methandrostenolone 453 20 2,6-Methano-3-benzazocines 62 20 Methantelinium bromide (Banthine®) 420 18 Methaqualone (Melsedin®) 461 20 - 389 18 Methasquin 116 16 Methazolamide 220 22 Methenamine (Urotropin®) 29 22 Methenolone acetate (Primobolan®) 69 16 Methici1lin (Celbenin®, Staphicillin®) 313,

314,317,323 22 - 50 22 Methimidazole (Tapazole®) 77 19 Methionine 468 23 L-Methionine S-adenosyltranferase 143 20 Methionine-enkephaline 398 22 Methionine-enkephaline 198 16 Methionyl-tRNA-Synthetase 394,404,434 22 Methisazone (Marborane®) 63 19 Methocarbamol 290,297 20 Methoserpidine (Decaserpyl®) 408 16 Methotrexate (Amethopterin®) 92, 103,

118 17 - 324 18 - 107 20 - 470,471,583 22 - 64 18 Methotrimeprazine 455 20 Methoxamine 28, 32 17 2-Methoxy-6-chloro-9-aminoacridine 295 17 2-Methoxy-6-chloro-9-[(hydroxyethyl )ami-

no ]acridine 295 16 6-Methoxy-I,9-dimethyl-9H-pyrido[3,4-

b ]indole 100 17 Methoxyflurane (I, l-difluoro-2,2-dichlo-

roethyl methyl ether 16, 76 17 d-3-Methoxy-N-methylmorphinan 23 17 1-3-Methoxy-N-methylmorphian 23 17 6-Methoxy-4-(morpholinoamino )quinal-

dine 271 18 Methoxypromazine 433 22 Methscopolamine 368 22 N-Methyl-2-adamantyl-3' -spiropyrroli-

dine 278 16 Methyl p-alkoxypropionates 272 16 Methylasparatat-Aminotranferase 396 17 2-Methyl-I,2-bis(3-pyridyl)-I-propanone

(metyrapone, SU-4885) 15 16 3-Methylcholanthrene (MCA) 98,249,254 17 - 17,372,497 20 Methylc10thiazide 210 16 p-Methylcrotonamide 241 21 Methyl-cyanoacrylate 345 21 p-Methyldigoxin 113 16 6-Methyl-2,3-dihydropyran-2,4-dione-3-

carboxylic acid 261 16 5-Methyldodecanoic acid 239

Index Vol. 16-23

20 a-Methyldopa (Aldomet®) 218,220,411 20 a-Methyldopamine 413 16 Methyl 11-eicosenoate 268 22 Methylene blue 37 18 Methylene chloride 378 22 3-Methylene oxindole 286 16 Methyl erucate 268 23 p-Methyl escalutin 71 21 2-Methyl-2-ethyl-4-phenyl-4-cyc1ohexene

carboxylic acid (ORF 3858) 322 22 3-Methylfentanyl 186 16 5-Methyl-2-furanacrylamide 242 22 N-Methylfuryl-6.7-benzomorphans 164 20 N-Methylglucamine antimoniate (Glucan-

thine®) 442 16 N-Methylglutamat-Synthetase 414 17 Methylglyoxal bis(guanylhydrazone) 376 17 7-Methylguanine 369 16 Methyl heneicosate 270 16 16-Methylheptdadecanoic acid 304 16 15-Methylhexadecanoic acid 304 16 Methyl2-hydroxyhexadecanoate 281 16 Methyl12-hydroxy octadecanoate 270 16 Methylmalonat-Semialdehyd-Dehydroge-

nase400 19 Methyl malonic acid 286 16 Methylmalonyl CO-A-Mutase 402 17 Methylmelamine 362 22 5-Methylmethadone 194 18 I-Methyl-methylergometrine 414 16 MethyI3-methylnon-2-enoate 243 16 MethyllO-methyloctadecanoate 270 20 N-Methylmorphian 398 21 I-Methyl-5-nitroimidazole 352 19 N-Methyl-N' -nitro-N-nitrosoguani-

dine 466 17 I-Methyl-I-nitrosourea 366 16 3-Methylnonanoic acid 238 20 a-Methylnoradrenaline 413 20 a-Methylnorepinephrine 220 16 Methyl 9-octadecanoate 274 22 a-Methyl-paratyrosine 368 22 Methyl-patricin 132 16 14-Methylpentadecanoic acid 304 18 Methylphenidate (Ritalin®) 438 20 - 397 23 Methylphenobarbital 114 21 15-Methyl-17-phenyl-18,19,20-trinorpros­

taglandin Fa. 32 16 Methylprednisolone (Medrol®, Urba-

son®) 103 20 - 584 22 - 74 21 15-Methyl-prostaglandin Fa. 326,371 16 Methylscopolamine 342 22 9-Methylstreptimidone 311 17 6-(Methylsulfinyl)-8-oxopurine 340 17 6-(Methylsulfinyl)purine 340 22 17a-Methyltestosterone (Metandren®) 69 17 5-(Methylthio )-2,4-dithiocyanatothio-

phene 302 17 6-(Methylthio )-8-oxopurine 340

Index Vol. 16-23

17 6-(Methylthio )purine 338 17 6-(Methylthio)purine ribonucleoside 337 17 6-(Methylthio )purine ribonucletide 337 17 1-Methyl-4-[3,3,3-tris(p-chlorophenyl)pro­

pionyl)piperazine hydrochloride 118, 133, 287

16 a-Methyl-m-tyramine 347 16 a-Methyltyrosine 220,357 16 a-Methyl-p-tyrosine 337 16 3-Methylvaleric acid 284,285 18 Methymycin 418 20 Methyprylon (Noludar®) 387 16 Methyridine (Dekelmin®, Mintic®, Pro-

mintic®) 158, 171 17 - 123, 159, 165, 169, 174, 176 19 - 150 22 - 49 21 Metioxate 33 20 Metolazone 210 22 Metopirone® (metyrapone) 77 20 Metoprolol (Lopresor®) 33, 229, 230, 411 16 Metrazol 219,349 20 Metrifonate (Bilarcil®, Dipterex®) 448 22 - 47 17 Metronidazole (Clont®, Flagyl®, Tricha-

zol®) 125, 179 18 - 327,359,363 19 - 539 20 - 438,439 22 - 46 17 Metyrapone [SV-4885, 2-methyl-l ,2-bis(3-

pyridyl)-propanone, Metopirone®) 15,24 22 - 77 23 Mezereine 86 16 MGA® (melengestrol acetate) 92 20 MGA® (melengestrol acetate) 586 16 MIC (minimal inhibitory concentra-

tion) 313 17 Michaelis-Menton equation 19 22 Miconazole (Daktarin®) 36, 109, 114 18 Microbacterium leprae 54 16 Microbiological oxidation 57 16 Micrococcaceae 330 16 Micrococcus lysodeikticus 310,328 17 Microelectrode techniques 38 18 Microfilaria 270 19 Micro filaria 148 22 Microlut® (norgestrel) 74 17 Microorganisms 228 20 Midamor® (amiloride) 417 22 Midicel® (sulfamethoxypyridazine) 31 19 Milk supply 571 19 Minimal agar plates 467 16 Minimal inhibitory concentration

(MIC) 313 20 Migraine 38 20 Migration inhibitory factor 585 17 Milibis® (glycobiarsol) 123 22 Minocin® (minocycline) 53 22 Minocycline (Minocin®) 53 , 20 Minoxidil 234,415

17 Mintezol (thiabendazole) 125 20 Mintezol (thiabendazole) 452 22 Mintezol (thiabendazole) 49 17 Mintic® (methyridine) 123 16 Miracil A 24,25 16 Miracil A congeners 27 16 Miracil B 24,25,37 16 Miracil C 24,25 16 Miracil D® (lucanthone) 24 17 Miracil D® (lucanthone) 115, 141, 144,

147,245 18 Miracil D® (lucanthone) 16 19 Miracil D® (lucanthone) 154 22 Miracil D® (lucanthone) 47 16 Miracil D sulfone 31 16 Miracil D sulfoxide 31 16 Miracil X 31 16 Miracils schistosomicidal activity 26 16 Mirasan (N'-(3-chloro-p-tolyl)-N,N-

diethylethylenediamine) 52 17 - 250 16 Mirasan analogs 53,56 17 Mithramycin 378 20 Mithramycin 474 17 Mitomycin A 364 17 Mitomycin B 364 16 Mitomycin C 89 17 Mitomycin C 364 19 Mitomycin C 467 20 Mitomycin C 468 22 Mitotane (Lysodren®) 77 20 Mitotic inhibitors 473

265

17 MJ 1999 [4-(2-isopropylamino-l-hydroxy-ethyl)methanesulfonanilide HCI) 35, 53

20 Mogadon® (nitrazepam) 389,393 22 Mogadon® (nitrazepam) 261 23 Molar refractivity 135 23 Molar volume 135 23 Molecular connectivity 126, 209 23 Molecular connectivity index 126, 209 20 Molecular modification 11, 15, 145 23 Molecular orbital 209 20 Molecular pharmacology 101 16 Mol-Gewichtsbestimmung 367 17 Moniezia benedeni 151 17 Moniezia expansa 151,294 17 Monieziasis 151 22 3-Monoacetylmorphine 154 22 6-Monoacetylmorphine 154 17 Monoamineoxidase inhibitors 24 20 Monoamineoxidase inhibitors 216 22 Monoamineoxidase inhibitors 364 16 Monoamine-oxydase 336,344 16 Monoamino-Oxidase 404,412 18 Monochlorodifluoroethane 381, 387 18 Monochlorodifluoromethane 387 20 Monocytes 577 17 Monoiodoacetic acid 65 20 Monomycin 444 17 Monomycin A® 122 17 Monopar® (stilbazium iodide) 124

266

17 Monosaccharides 69 16 L-trans-4-Monotritioproline 296 21 Montanoa tomentosa 325 18 Moperone 437 16 Morantel (Banminth II) 164 17 Morantel (Banminth II) 124, 160, 165, 172 17 Moranyl® (suramin sodium) 132 20 - 445 20 Morbidity statistics 495 23 Morphinan 204 20 Morphinan derivatives 59 23 Morphinan derivatives 165, 166 17 Morphine 469 20 Morphine 82,333,398 22 Morphine 151,211 23 Morphine 116 18 Mosquitoes 181,270,283 20 Motrin® (ibuprofen) 402 22 Moxestrol 71 22 Mucidin 131 20 Mucous membranes, infection of 361 17 Muellerius capillaris 178 17 Multiceps multiceps 153 19 Mumps 280 18 Murine tuberculosis 218 19 Muscle relaxants 296 20 Muscle relaxants 420 19 Muscle rigidity 305 19 Muscle spasms 250 22 Myambutol® (ethambutol) 36 20 Myanesin® (mephenesin) 392 22 Mycifradin® (neomycin) 56 23 Mycobacterium arthritidis 47 18 Mycobacterium leprae 27,54,57, 159 18 Mycobacterium tuberculosis 33, 155,215 23 Mycobacterium tuberculosis 47 22 Mycophenolic acid glucuronide 132 17 Myleran® (busulfan) 365 22 Myleran® (busulfan) 64 17 Myleran analogs 366 18 Myocardial depression 393 17 Myocardial infarction 39 19 Myocarditis 416 19 Myocardium 307 22 Myolastan® (tetrazepam) 250 17 Myometrium 454 16 Myosin 380 20 Mysoline® (primidone) 387 19 Mytolon 296 17 Myxin 302

N 16 NADH-Cytochrom bs-Reductase 440 22 Nadisan® (carbutamide) 80 16 Na-Dodecylsulfat (SDS) 366 17 Naftamon® (bephenium hydroxynaph-

thoate) 158 17 Nagronol® (suramin sodium) 132 20 Nalbuphine 58, 89 21 Nalidixic acid (Negram®, NegGram®,

Nogram®) 11,62

Index Vol. 16-23

22 Nalidixic acid (Negram®, NegGram®, Nogram®) 34

22 Nalorphine 157 20 Naloxone 56, 78, 93, 333 22 Naloxone 151 23 Naloxone 117 20 Naltrexone 58,78,93 23 Naltrexone 117 22 Nandrolone decanoate (Deca-Durabo­

lin®) 69 22 Nandrolone phenylpropionate (Durabo-

lin®) 69 20 Naphazoline (Privine®) 220, 420 23 Naphthalene 110 16 Naphthalophos (Maretin®, Rametin®,

phthalophos) 158, 168 17 - 129, 158, 168, 170 22 3-a-N aphthyl-5-diethylcarbamoyl-I,2,4-

oxadiazole 288 21 1,5-Naphthyridines 48 21 1,6-Naphthyridines 49 21 1,7-Naphthyridines 51 21 1,8-Naphthyridines 51 20 Naprosyn® (naproxen) 402 20 Naproxen (Naprosyn®) 402 20 Narcotic antagonists 46 20 Narcotic antagonists agonist actious 46 20 Narcotic antagonists chemistry 51 20 Narcotic antagonists clinical studies 89 20 Narcotic antagonists metabolism 75 20 Nardil® (phenelzine) 395 16 NAS (National Academy of Sciences) 201 16 Nasal flora 324 22 Natamycin 107 16 National Academy of Sciences (NAS) 201 20 National Academy of Sciences (NAS) 171 23 National Economic Development Office

(NEDO) 51 20 National Institutes of Health (NIH) 20,

164 19 National Nutrition Programmes 136 16 National Research Council (NRC) 201 20 National Research Council (NRC) 171 20 Natural products 144 23 Natural products analogs 53 18 Natural products metabolism 440 23 Natural products research 51 20 Naturetin® (bendroflumethiazide) 417 20 Navidrex® (cyclopenthiazide) 417 16 NDA (New Drug Application) 196 22 Nebcin® (tobramycin) 56 16 Necatoramericanus 163,165 17 Necator american us 160 18 Necator american us 199 19 Necator american us 17,25,29,36,46,56,

64,70,81,86,90,96, 161, 170, 173 20 Necator american us 453 17 Necatorina® (carbon tetrachloride) 116 22 Negram® (nalidixic acid) 34 21 NegGram® (nalidixic acid) II 22 NegGram® (nalidixic acid) 34 17 Neguvon® (trichlorfon) 128

Index Vol. 16-23

17 Nema8 (tetrachlorethylene) 130 16 Nematocidal activity 166 16 Nematodes 158 17 Nematodes 122, 155 20 Nematodes 350 16 Nematodiasis 158 17 Nematodirus battus 165 17 Nemazine8 (phenothiazine) 131 20 Nembutal8 (pentobarbital) 387 17 Nemural® (drocarbil) 121 18 Neoarsphenamine 331 17 Neoascaris vitulorum 157 19 Neo Bedermin® 103 17 Neocuproine 14 17 Neohydrazid® (cyanacethydrazide) 131 22 Neomercazole® (carbimazo1e) 77 16 Neomycin (Mycifradin®) 314 20 - 444 22 - 56 22 Neomycin B 56 18 Neomycin E 422 18 Neomycin F 422 22 Neopinone 152 16 Neoplasia 80 20 Neoplasm, drug resistance 480 20 Neostibosan® (ethylstibamine) 442 19 Neostigmine 329,521 20 Neosynephrine® (phenylephrine) 419 22 Neoteben® (isoniazid) 34 20 Nepresol® (dihydralazine) 409 16 Nervenwachstumsfaktor 374, 378 20 Nethalide® (pronethalol) 28 18 Neuramidinase 255 20 Neuramidinase 328 17 Neuraminic acid 79 20 Neurochemical systems 301 16 Neurochemistry 354 19 Neuromuscular irritability 216 19 Neuromuscular mechanisms 148 16 Neuron 216 21 Neuron 411 16 Neuronal activity 212 19 Neuronal membranes 303 20 Neuropeptides 285 16 Neurophysin 374 16 Neurotoxin 378 20 Neurotransmitters 288 20 Neutrophiles 577 16 New Drug Application (NDA) 196 16 Nialamide 343 20 Nialamide 217 17 Nicarbazin 273 20 Nicergoline 235 17 Nic1ofolan (menichiophoIan, Bayer 9015,

Bilevon-M®) 134 17 Nic10samide (2', 5-dichioro-4' -nitrosalicyI­

anilide, phenasaI, Yomesan®) 119, 138, 139,148-154,296,297

18 - 198 20 - 447 22 - 46

16 Nicotinamidase 436 17 Nicotinamide 24 16 Nicotine 217 20 Nicotine 200, 335 19 Nicotinic acid 521 22 Nicotinic acid 86 20 Nifedipin (Adalat®) 241,407 20 Nifenalol 32, 225 18 Nifurtimox (Lampit®) 323 22 - 45 17 Nigericin 68 20 Nikethamide (Coramine®) 397 18 Nilevar® (norethandrolone) 451 22 Nilevar® (norethandrolone) 70 17 Nilodin® (lucanthone) 115 17 Nilverm® (tetramisole) 125 17 Nilzan 166 22 Nimetazepam (Erimin8 ) 262 20 Nimorazole 441 23 Nippostrongylus brasiliensis 48 16 Niridazole (Ciba 32644-Ba; Ambil-

har®) 14, 16,22 17 - 117,138,142,145-147,178,182,261 18 - 327 19 - 153, 154 20 - 448,587 22 - 47 16 Niridazole, Cl4-labelled 21 16 Niridazole congeners 16, 17 16 Niridazole hydroxylamino derivatives 21 16 Niridazole schistosomicidal action 19 16 Niridazole side effects 22 22 Nisentil® (alphaprodine) 172 17 Nistatin 67 20 Nitrazepam (Mogadon®) 389, 393 22 - 261,356,366 20 Nitrimidazine 439 19 Nitroblue tetrazolium test 245 17 7-Nitro-6-demethyl-6-deoxytetracy-

cline 222 22 Nitrofural (nitrofurazone, Furacin®) 33 16 Nitrofurans 60 21 Nitrofurantoin (Furadantin®) 351 22 - 33 20 Nitrofurazone (Furacin®) 446 21 - 352 17 Nitrogen mustard (HN2, mechlor-

ethamine) 349 20 - 467,480 23 - 38 20 Nitroglycerin 406 17 Nitromin 349 17 5-Nitro-I,10-phenanthroline 14 17 1-{3-[(4-Nitroso-I-naphthyl)amino]pro-

pyl}piperidine 259, 268 20 Nitrosoureas 469 16 Nitrothiazoles 15 17 5-Nitro-4-thiazolines 264 16 (5-Nitro-4-thiazolin-2-ylidene) ureas 15,

18 17 1-(5-Nitro-2-thiazolyl)hydantoin 270

267

268

17 1-(5-Nitro-2-thiazolyl)-2-pyrro­lidinone 261

17 2-[2-(5-Nitro-2-thiazolyl)vinyl)pyri­dine 264

17 2-(5-Nitro-2-thienyl)benzimidazoles 307 17 Nitroxynil (4-cyano-2-iodo-6-nitrophenol;

Trodax®) 117,136,278,280 16 NLT (Normal lymphocyte transfer) 102 22 Nobrium® (medazepam) 249,261 22 Nocardicin A 53 21 Nogram® (nalidixic acid) II 20 Noludar® (methyprylon) 387 17 Nonactin 69 19 Non-agglutinable vibrios 508 16 Nonane-I,9-dioic acid 235 16 Nonanoic acid 244 17 Non-electrolytes, transport of 69 17 Noradrenalin 491 20 Noradrenalin 410 22 Noradrenalin 368 20 Noradrenaline 410 20 6-Noralkyl-Ilp-methyl-2,6-methano-3-

benzazocines 63 20 Noramidopyrinium methansulfonate

(Novalgin®) 401 20 Norcyclazocine 77 20 Norcyclazocine glucuronide 77 16 Norepinephrine 220,336,346 19 Norepinephrine 149 20 Norepinephrine 219,220 21 Norepinephrine 420 20 Norepinephrine biosynthesis 218,219 18 Norethandrolone (Nilevar®) 451 21 - 348 22 - 70 21 Norethindrone (Norlutin®) 298 22 - 72 18 N orethisterone 449 21 Norethisterone 324,250 21 N orethisterone acetate 300 21 Norethisterone oenanthate 303 18 Norethynodrel 449 21 Norethynodrel 298,348 22 Norethynodrel 72 18 Norgestrel (Microlut®) 449 21 - 308,311 22 - 74 21 d-N orgestrel 300 21 Norgestrienone 308,321 22 Norlutin® (norethindrone) 72 16 Normal lymphocyte transfer (NLT) 102 20 Normatensyl® 409 22 D-Normorphinan 167 22 Normorphine 154 20 Nornaloxone 78 20 Noroxymorphone 56 20 Northebaine 53 18 Nortriptyline 457 19 Notatin 286 20 Notezine® (diethylcarbamazine) 455

Index Vol. 16-23

16 Notice of Claimed Investigational Exemp­tion for a New Drug (IND) 196

20 Novalgin® (noramidopyrinium methansul-fonate) 401

17 Novazole® (rafoxanide) liS 20 Noveril® (dibenzepin) 394 16 Novobiocin 318 21 Novobiocin 177 20 Novocaine® (procaine) 403 20 Novonal 387 16 NRC (National Research Council) 201 18 Nucleocapsid 253 16 Nucleosid-Diphosphat-Kinase 390 20 Nupercaine® (cinchocaine) 403 18 Nystatin 322,418 22 Nystatin 97, 101

o 16 Octadecanoic acid 244 16 [J-I4C)-cis, cis-Ll9, 12-0ctadecadienoic

acid 288 16 cis-Octadec-9-enoic acid 287 16 [J-I4C)-trans-Octadec-9-enoic acid 289 18 Octafluorocyclobutane 382 20 Octahydrobenzofg)quinolines 74 23 1,2,3,4,6,7,12, 12a-Octahydropyrazino-

[2', I': 6, l)pyrido(3,4-b)indoles 214 16 Octane-I,8-dioic acid 235 17 1,2, 8-0ctanetricarboxylic acid 416 16 Octanoic acid 243 23 n-Octanol 102 17 Octyl-(7 -carbomethoxyheptyl )butyrolac-

tone 418 23 Oedema 30 17 Oesophagostomum columbianum 165 21 Oestradiol 323, 333 21 Oestradiol cyclopentyl propionate 319 21 Oestriol 302 21 Oestrogen 298,318,348 23 Ogawa vaccine 14 21 Oleandomycin 175 22 Oleandomycin 58 17 Onchocerca volvulus 183 18 Onchocerca volvulus 142,260 19 Onchocerca volvulus 128 20 Onchocerca volvulus 456 17 Onchocerciasis 182 18 Onchocerciasis 44 20 Onchocerciasis 456 22 Oncovin® (vincristine) 64 17 Oochoristica symmetrica 303 23 Opacity test 16 20 Opiate dependence, treatment of 93 20 Opiate receptor 79 22 Opiate receptor 211 20 Opiate receptor isolation 79 20 Opiate receptor models 82 20 Opioid narcotic drugs 330, 332 22 Opioid pep tides 195 20 Opioid receptor 330

Index Vol. 16-23

20 Opioid receptor interaction 333 20 Opioid receptor, sodium effect on 331 20 Opipramol (Insidon®) 394 17 Opisthorchiasis 138, 276 20 Opisthorchis 450 17 Opisthorchis felineus 138, 276 17 Opisthorchis viverrini 138, 288 19 Opisthotonus 201 22 Opium alkaloids 151 22 Orabolin® (ethylestrenol) 70 21 Oral contraceptives 313 22 Orbenin® (cloxacillin) 50 20 Orciprenaline (Alupent®) 419 21 ORF 1616 [l-(N,N-diethy1carbamyl­

methyl)-2,4-dinitropyrrole] 352 21 ORF 3858 (2-methyl-2-ethyl-4-phenyl-4-

cyc10hexene carboxylic acid) 322 22 Orgametril® (lynestrenol) 74 22 Orinase® (tolbutamide) 80 22 Oripavin 152 22 Orisul® (sulfaphenazole) 31 16 Ornithin-Aminotransferase 400 18 Ornithine 426 23 Ornithine decarboxylase (ODC) 90 20 Orudis® (ketoprofen) 402 17 Osmosis 93 17 Osmotic pressure 92 17 Ostertagia ostertagi 165 16 17p-Ostrol-Dehydrogenase 370,394 20 Otrivine® (xylometazoline) 420 17 Ouabain 35,67 16 Ovalacin 91 23 Ovalbumin 45 21 Overpopulation 295 23 Ovomucoid 33 21 Ovulation inhibition 298 21 Ovum transport 323, 373 16 Oxacillin (Bactoci11®, Prostaphlin®, Stape-

nor®) 314,322 22 - 50 17 Oxamniquine (UK 4271) 253 20 - 448 22 Oxandrolone (Anavar®) 70 20 Oxanthel pamoate 453 17 Oxaprostaglandins 468 17 7-0xa-13-prostynoic acid (compound

19396) 469 18 Oxazepam (Serax®, Serenid®) 434 20 - 393 22 - 242 22 Oxazolam (Serenal®) 252 20 Oxedrin (Sympatol®) 411 16 a-Oxidation, mechanism of 278 16 w-Oxidation 232,233,243 20 Oxilorphan 62, 83 22 Oxilorphan 163 22 Oxine 128 20 Oxisuran 587 17 Oxoallopurinol 340 17 15-0xo-dihydroprostaglandin E, 441,446 17 15-0xo-13,14-dihydroprostaglandin E2 444

17 15-0xo-13,I4-dihydroprostaglandin F1a 444

22 Oxolin 302 21 Oxolinic acid 31 17 15-0xoprostaglandin E, 445,446 16 Oxotremorine 346,350 20 Oxprenolol (Trasicor®) 34,36,221,226,

229,230,411 20 p-Oxprenolo1 227 22 Oxyamylose 273 17 Oxyclozanide (3,3',5,5' ,6-pentachloro-2'­

hydroxysalicylanilide; Zanil®) 115, 135, 281

269

20 Oxyfedrin (Ildamen®) 406 17 Oxyformycin B 344 20 Oxygen metabolism 537 17 Oxygen transport 92 17 8-0xy-6-mercaptopurine 340 22 Oxymetholone (Anadrol®) 69 22 Oxymorphine 151 20 Oxymorphone 56 20 Oxyntel pamoate 453 17 Oxyphenbutazone (Tanderi1®) 401 20 - 490 20 Oxyphenonium bromide (Antrenyl®) 420 17 Oxytetracycline (Terramycin®) 211,212,

228 18 - 331 22 - 53 20 Oxytocin 286 17 Oxytremorine 26 17 Oxyuriasis 171 17 Oxyuris equi 172

P 20 Pactamycin 585 22 Palfium® (dextromoramide) 189 18 Palitantin 331 16 Palmitic acid-I-'''C 277 17 1-Palmitoyl-2-([2' -'''C]-eicosatrienoyl)gly-

cero-3-phosphory1choline 440 20 Paludrine® (chloroguanide, proguanil) 435 22 Paludrine® (chloroguanide, proguanil) 44 18 PAM-I,392 (2,4-diamino-6-[(3,4-dichloro-

benzyl)amino ]quinazoline 110 22 Pamaquine (Plasmochin®) 40 18 Pamoic acid 328 22 Panacid® (piromidic acid) 34 16 Pankreasamylase 370 20 Panparnit® (caramiphen) 420 22 Pantothenic acid 86 22 Papaveretum 211 20 Papaverine 406 20 Paracetamol 400 22 Parachlorophenylalanine 369 23 Parachor 135 23 Paracyclophane 133 17 Para filaria bovicola 183 17 Para filaria sahaii 183 17 Parafilariasis 183 17 Paragonimiasis 138, 292

270

20 Paragonimiasis 450 17 Paragonimus westermani 292 18 Paragonimus westermani 197 19 Paraldehyde 210,225,246,330,362 19 Paralysis 298, 445 22 Paramethasone 74 22 Paramethasone acetate (Haldrone®) 75 20 Paramomycin (Humatin®) 447 17 Paramphistomiasis 139 17 Paramphistomum microbothrium 139,292 16 Paramyosin 378 17 Paraoxon (E 6(0) 489 20 Paraphenylquinone 46 17 Pararosaniline [tris(p-aminophenyl)carbo-

nium, TAC] 118,255 17 Pararosaniline pamoate 147 17 Parascaris equorum 156 18 Parasites 181 19 Parasitic diseases 147 19 Parasitic diseases control 50 20 Parasitic infections 355, 434 18 Parasitoses 192 19 Parasitosis, intestinal 10 17 Parathion (E 605) 489 16 Parbendazole (Helmatac®, Verminum®,

Worm Guard®) 159, 160 17 - 126,157,164,170,174 22 - 49 19 Paresis 445 17 Pargonyl® (paromomycin) 122 16 Pargyline 220, 349 20 Pargyline 217 16 Parkinsonism 338,343 20 Parkinson's disease 423 20 Pamate® (tranylcypromine) 396 17 Paromomycin (Humatin®, Monomycin A,

Pargonyl®) 122, 148, 151, 153, 154 18 - 330 20 - 447 17 Paromomycin sulphate 302 18 Paromomycin I 422 18 Paromomycin II 422 23 Partition coefficients 102, 112, 119 23 Partition coefficient-calculation 107 18 PAS (p-aminosalicylic acid) 212 22 PAS (p-aminosalicylic acid) 34 19 Pasteurella haemolytica 587 19 Pasteurella pestis 546 19 Pasteurella septica 546 20 pazoxide 233 16 P-Creatine 345 16 Pea leaves 281 22 Pecilocin 130 20 Pempidine (Perolysen®) 202,410 22 Penbritin® (ampicillin) 50 20 Pendiomid® (azamethonium bromide) 409 20 Penicillamine 362 16 d-Penicillamine 88, 118 18 Penicillin 331 19 Penicillin 289, 330, 393, 413, 467 20 Penicillin 440

21 Penicillin 131 23 Penicillin 51 16 Penicillin G 313 21 Penicillin G 176 22 Penicillin G 50 22 Penicillin V 50 16 Penicillinase 326

Index Vol. 16-23

19 Penicillium notatum 286 17 3,3',5,5',6-Pentachloro-2' -hydroxysalicyl-

anilide (oxyclozanide, Zanil®) 281 22 Pentachlorophenyl dodecanoate 128 20 Pentamethonium 200 18 Pentamidine (Lomidine®) 318 20 - 443 22 - 45 20 Pentazocine (Fortral®, Talwin®) 62,64,75,

81,89,398,399 22 - 160,211 20 Pentetrazole (Cardiazol®) 397 22 Pentizidone sodium 55 18 Pentobarbital (Nembutal®) 453 20 - 378 21 - 113 22 Pentobarbitone 362 20 Pentolium tartrate 20 I 20 Pentostam® (sodium stibogluconate) 442 20 Pentothal® (thiopental) 387 16 Peptidase 328 18 Pep tides 425 20 Pep tides 294 22 Pep tides 308 23 Peptides 57 16 Peptidyl-5-hydroxylysine 296 16 Peptidyl-4-hydroxyproline 293 19 Peptone water culture 472 18 Perazine 455 20 Periactin® (cyproheptadine) 426 20 Perolysen® (pempidine) 410 16 Peroxidase 406 17 11-Peroxy-8, 12, 14-eicosatri-enoic acid 436,

437 18 Perphenazine 433 20 Persantin® (dipyridamole) 406 19 Pertussis 347, 356 23 Pertussis 14 19 Pertussis agglutinin 180 19 Pertussis agglutinogens 345 23 Pertussis agglutinogens 16 19 Pertussis antibodies 178 19 Pertussis antigens 343 19 Pertussis epidemiology 257 19 Pertussis infection 184,257,344 19 Pertussis immunization 261,358 19 Pertussis serotypes 342, 348 19 Pertussis strains 342 23 Pertussis toxins 13 19 Pertussis vaccines 178,229,277,341 23 Pertussis vaccines 12, 16 19 Pertussis vaccine test 350 17 Pethidine (meperidine, Dolantin®) 488 20 - 398

Index Vol. 16-23

22 Pethidine (meperidine, Dolantinill ) 168, 211

17 Ph 1882 (bromofenfos, Acedist®) 113 16 PHA (Phytohemagglutinin) 73, III 16 Phagocytosis 316 23 Phagocytosis 15 22 Phanquinone (Entobex®) 42 20 Pharmaceutical industry 15, 19, 160, 182 20 Pharmaceutical Manufacturers Association

(PMA) 162 20 Pharmaceutical research 192, 511 23 Pharmaceutical research 52 21 Pharmacokinetics 124 20 Pharmacological research 16 20 Pharmacological test system 145 16 Pharmacology 199 20 Pharmacology 146 18 Phebotomus argentipes 283 20 Phenacetin 400 23 Phenacetin 114 17 Phenalglycodol 25 23 Phenanthrene carbinols 210 17 o-Phenanthroline 496 17 1,100Phenanthroline 14 17 Phenasal (niciosamide) 119,297 20 Phenazone (antipyrin) 401 20 Phenbenzamine (Antergan®) 424 20 Phenbutol 227 21 Phencyclidine 113 20 Phenelzine (Nardil®) 217,395 22 - 365 20 Phenergan® (promethazine) 426 23 Phenethylamines 142 22 Phenformin 80 16 Phenindiamine (Thephorin®) 342 20 - 426 20 Phenindione (Danilone®) 404 20 Pheniprazine 217 20 Phenmetrazine (Preiudine®) 419 16 - 249,254 17 - 494 18 - 453 20 - 387 19 Phenobarbitone 246, 294, 298, 330, 362,

379 17 Phenobutiodil [2-(2,4,6-triiodo-

phenoxy)butyric acid, Trijobil®] 299 22 Phenols 29,46 23 Phenols 105 22 Phenoperidine 211 16 Phenothiazine (Antiverm®, Helmetina®,

Nemazine®, Vermitin®) 159 17 - 131,168 17 Phenothiazines 76 18 Phenothiazines 433 21 Phenothiazines 439 23 Phenoxyacetic acids 108 17 Phenoxyalkanes 285 21 Phenoxybenzamine hydrochloride 358 17 Phentolamine (Regitine®) 51 20 - 206,221,426,413 16 /-Phenylalanine mustard 86

16 Phenylalanin-Hydroxylase 406 23 Phenylalanyl-phenylalanine 34 16 Phenylalanyl-tRNA-Synthetase 404,408 22 5-Phenyl-l,5-benzodiazepinediones 258 22 5-Phenyl-2,4-benzodiazepinones 259 22 5-Phenyl-l,4-benzodiazepin-2-ones 242

271

17 Phenylbutazone (Butazolidineill) 17,23,26, 75,490

20 - 401 23 - 114, 179 17 3-Phenyl-4-[( dialkylamino )alkyl]pyrazol-5-

ols 309 17 1,4-Phenylenebis(dithiocarbamic acid es­

ters) 289 18 4',4'" -fp-Phenylenebis(methylidyneimino­

p-phenylenesulfonyl)]bisacetanilide 163 16 Phenylene diisothiocyanate (1,4-phenyl­

enediisothioxyanate, 1,4-phenylenediiso­cyanate, bitoscanate) 158, 171

17 Phenylene diisothiocyanate (1,4-phenyl­enediisothiocyanate, 1,4-phenylenediiso­cyanate, bitoscanate) 300

19 Phenylene diisothiocyanate (1,4-phenyl­enediisothiocyanate, 1,4-phenylenediiso­cyanate, bitoscanate) 40

20 Phenylephrine (Neosynephrine®) 28,419 16 Phenylethylhexylketone 262 23 Phenyl-p-D-glycosides 139 17 Phenylisopropylhydrazine 25 17 4-[(5-Phenylpentyl)oxy ]-m-anisidine,

methanesulphonate of 255 20 4-Phenylpiperidines 71 22 4-Phenylpiperidines 168 23 Phenylpropanes 109 21 17-Phenyl-18,19,20-trinorprostaglandin

F2a 326 17 Phenyramidol 26 20 Phenytoin (Dilantin®) 387 23 - 114 16 Phenzidole 159 17 Phloretine 70 23 Phorbol esters 67 23 Phorbol-12,13-diesters 171 16 Phosphatase,alkalische 392,398,402,436 16 Phosphatase, saure 392,436 17 Phosphatidic acid 78 17 Phosphatidyicholine 77 17 Phosphatidylethanolamine 78 17 Phosphatidylserine 78 23 Phosphatidylserine 44 20 Phosphodiesterase 329 16 Phosphoenolpyruvat-Carboxylase 404,

414,440 16 Phosphoenolpyruvat-Carboxytrans-

phosphorylase 414 16 Phosphofruktokinase 400,416 19 Phosphofruktokinase 153 16 Phosphoglucose-Isomerase 398 17 Phosphoglycerate kinase 66 16 Phosphoglycerat-Mutase 390 16 3-Phosphoglycerat-Phosphatase 438

272

17 Phospholipase A 81,440 16 Phospholipase A2 434 23 Phospholipase A2 72,91 17 Phospholipids 72, 77 22 Phosphonoacetic acid 63, 305 16 Phosphopyruvat-Hydratase 436 17 Phosphoramide mustard 350, 359 16 Phosphoribosylpyrophosphat-Aminotrans­

ferase 418 16 Phosphoribosylpyrophosphat-Synthe-

tase 442 16 Phosphorylase B Kinase 420 17 Photodissociation 493 16 C-Phycocyanin 378,430 16 C-Phycoerythrin 430 22 Phylloquinone (vitamin K 1) 85 16 Physostigmine 346,356 22 Physostigmine 368 16 Phytanic acid 285 16 [U- 14C]-Phytanic acid 286 16 Phytochrom 378 16 Phytohamagglutinin 374, 376 16 Phytohemagglutinin (PHA) 73, III 20 Picodralazine 409 17 Picolinaldehyde thiosemicarbazone 347 18 Pikromycin 418 18 Pimaricin 418 21 Pimozide 415,416 22 Pinazepam (Domar®) 262 20 Pindolol (Visken®) 34,36,226,230,411 16 Pinworm 160, 163 18 Pinworm 191 21 Pipemidic acid 81 17 Piperazine (Antepar®) 126, 172 19 - 33,36, 149, 163, 166 20 - 451,452 22 - 48 17 Piperazine adipate 174 17 Piperazine hydrate 157 17 Piperonyl butoxide 13 20 Piperoxan 200 21 Piribedil 432 21 Piromidic acid (Panacid®) 79 22 - 34 23 Pituitary hormones 57 20 Pizotifen (Sandomigran®) 426 20 Placidyl® (ethchlorvynol) 387 19 Plague vaccine 275, 486 22 Plasmochin® (pamaquine) 40 17 Plasmodium berghei 263 18 Plasmodium berghei 102 23 Plasmodium berghei 210 18 Plasmodium cynomolgi 110 18 Plasmodiumfalciparum 101,249 20 Plasmodiumfalciparum 435 18 Plasmodium gal/inaceum 110 18 Plasmodium knowlesi III 18 Plasmodium malariae 101 18 Plasmodium vivax 101 19 Pleurothotonus 201 17 Plexaura homomalla 472

Index Vol. 16-23

18 Pneumocystis carinii 319 19 Pneumonia 307 23 Podolide 83 17 Podophyllotoxin 382 22 Podophyllotoxin 64 23 Podophyllum 69 20 Podophyllum derivatives 473 20 Polamidon® (methadone) 398 23 Polio 13 18 Poliomyelitis 279 19 Poliomyelitis 256 23 Poliomyelitis 21 16 Poliomyelitis-Virus 384 19 Polio vaccine 276 23 Polio vaccine II 23 Polio virus II 22 Polonowski rearrangement 241 22 Polyacrylic acid 272 23 Polyarthritis 47 22 Polycillin® (ampicillin) 50 22 Polycytidylic acid 271 22 Polyene antibiotics 95 22 Polyene antibiotics, alkyl esters 10 I 22 Polyene antibiotics, classification 96 22 Polyinosinic acid 271 17 Polymyxin B 68 19 Polymyxin B 466 22 Polymyxin B 59 22 Polymyxin E 59 19 Polynucleotides 281 . 16 Polynucleotid-Phosphorylase 406 17 Polyphloretin phosphate 470 16 Polysaccharid-Depolymerase 440 23 Polysaccharides 28 17 Polystichin (aspidin) 120 20 Poly thiazide (Renese®) 210,417 23 Polyvalent vaccine 13 20 Ponderal® (fenfluramine) 419 20 Ponstan® (mefenamic acid) 401 19 Pontamine sky blue 505 17 Porfiromycin 364 16 Potassium 212,214 17 Potassium antimony tartrate 244 17 Potassium canrenoate (Soldactone®, Solu-

dactone®) 47 22 - 76 17 Potassium ion 75 17 Potassium ion transport 63 19 Potassium loss 529 22 Potassium prorenoate 76 22 Potassium sorbate 130 20 Povan® (pyrvinium pamoate) 452 22 Povan® (pyrvinium pamoate) 48 16 PPD (Purified protein derivative) 102 16 Pra-Phenol-Oxidase 392 20 Practolol (Eraldin®) 28,34,36,229,411 19 Pralidoxime methanesulphonate 330 20 Prantal® (diphemanil) 420 22 Prazepam (Verstran®) 261 22 Praziquantel (Droncit®) 49 20 Prazosine 233,415

Index Vol. 16-23

20 Preclinical evaluation 146 21 Preclinical experiments 247 16 Prednisolone 92, 103 17 Prednisolone 24,383 20 Prednisolone 475, 583 22 Prednisolone 74 16 Prednisone 92 17 Prednisone 383 20 Prednisone 475 21 Prednisone 351 22 Prednylidene (Oecortilen®) 75 17 Pregnanolone 75 20 Preludin® (phenmetrazine) 419 21 Premarin® 310 17 Prenylamine (Segontin®) 75 20 - 406 19 Presynaptic apparatus 303,318 18 Primaquine 324 20 Primaquine 435 20 Primidone (Mysoline®) 387 22 Primobolan® (methenolone acetate) 69 20 Priscol® (tolazoline) 413 20 Privine® (naphazoline) 420 16 Probenecid (Benemid®) 337 20 - 402 17 Procainamide (procaine amide

Pronestylll» 36,45,51,488 20 - 406 16 Procaine (Novocaine®) 215 20 - 403 19 Procaine penicillin 210,224,379 16 Procarbazine 99 17 Procarbazine 370 18 Procarbazine 23 20 Procarbazine 476 16 Procarboxypeptidase A 394 20 Procinolol 227 22 Pro Diaban® (glisoxepide) 80 23 Product patent protection 53 16 Proflavin 100 21 Progestasert® 65, 335 16 Progesterone 262 17 Progesterone 24, 493 21 Progesterone 298,320,348 22 Progesterone 68, 72 21 Progestins 321 20 Proguanil (chloroguanide, Paludrin®) 435 22 - 44 20 Prolactin 287 22 Prolactin 360 16 Proliferation 74 17 Proline 491 20 Prolixin® (fluphenazine) 389 16 Prolyl-tRNA-Synthetase 394 19 Promazine 379 22 Promedol 172 22 a-Promedol 181 22 p-Promedol 181 22 y-Promedol 181 20 Promethazine (Phenergan®) 426, 445 21 - 414

23 Promethazine (Phenerganll» 40, 114 17 Prominticill (methyridine) 123 22 Promintic® (methyridine) 49 20 Pronase 79,332 20 Pronestyl® (procainamide) 406 20 Pronethalol (Alderlin®, Nethalide®) 28,

32,224,225,411 17 Prontosil rubrum 488 21 Prontosil rubrum 30

273

22 Propaderm® (beclomethasone 17,21-dipro-pionate) 74

18 Propane 388 17 m-(2-Propargyloxy)phenyl benzoate 309 18 Propellants 367 18 Propellants, pharmacologic action 391 18 Propellants toxicity 367 22 Propionic acid 130 16 Propionyl Co-A-Carboxylase 418 16 Propiophenone 262 22 Propiram 206 18 Propoquin® (amopyroquine dihydrochlo-

ride) 102 20 Propoxyphene (Oarvon®) 398 22 - 189 16 Propranolol (Inderal®) 355 17 - 51 18 - 460 19 - 361 20 - 28,33,36,224,225,226,411 23 - 54,118 17 d-Propranolol 67 17 I-Propranolol 53 20 Propylhexedrine (Benzedrexll» 419 16 2-n-Propyloctadecanoic acid 236 16 2-n-Propyltetradecanoic acid 236 22 Propylthiouracil 77 22 Prostacyclin 84 17 Prostaglandin 413 18 Prostaglandin 427 19 Prostaglandin 526 20 Prostaglandin 242 21 Prostaglandin 371 23 Prostaglandin 54 17 Prostaglandin antagonist 468 17 Prostaglandin analysis 428 17 Prostaglandin antilipolytic action 466 17 Prostaglandin antisecretory action 461 17 Prostaglandin biosynthesis 430, 433 17 Prostaglandin bronchodilator activity 462 17 Prostaglandin configuration 418 17 Prostaglandin diuretic effects 464 17 Prostaglandin enzymatic synthesis 439 17 Prostaglandin isolation 413 17 Prostaglandin metabolism 440 17 Prostaglandin nomenclature 420 17 Prostaglandin occurrence 423 17 Prostaglandin structure 415 17 Prostaglandin synthese 470 17 Prostaglandin synthetase 431, 433 17 Prostaglandin vasodepressor activity 463 17 Prostaglandin LlI3-reductase 449

274

17 Prostaglandin A isomerase 451 17 Prostaglandin A, (POA,) 417,430,451 18 Prostaglandin A, (POA,) 428 17 Prostaglandin A" w-hydroxy1ation of 450 17 Prostaglandin A2 (POA2) 425 18 Prostaglandin A2 (POA2) 428 17 Prostaglandin B, (POB,) 415,430,451 18 Prostaglandin B, (POB,) 428 18 Prostaglandin B2 (POB2) 428 17 Prostaglandin E, (POE,) 415,418,424,

429,430,434,441 18 Prostaglandin E, (POE,) 427 18 Prostaglandin E,-methy1ester 428 17 Prostaglandin E2 (POE2) 418,424,429,430 18 Prostaglandin E2 (POE2) 427,443 20 Prostaglandin E2 (POE2) 586 21 Prostaglandin E2 (POE2) 327,371,374 17 Prostaglandin E2 metabolism 442, 452, 453 17 Prostaglandin E3 (POE3) 418,424,429,430 18 Prostaglandin E3 (POE3) 427 17 Prostaglandin F,. (POF,.) 415,418,424,

437 18 Prostaglandin F,. (POF,.) 427 17 Prostaglandin F IP 415,424 17 Prostaglandin Flo (POFlo) 420,431,441 18 Prostaglandin Flo (POFlo) 428,443,446 21 Prostaglandin Flo (POFlo) 325,371,374 22 Prostaglandin Flo (POFlo) 84 17 Prostaglandin Flo' metabolism of 452,453 17 Prostaglandin F 3a 420, 425 17 Prostaglandin F 7/1 420 17 Prostaglandin F 3P 420 22 Prosta1ene (Synchrocept@) 84 17 Prostane 423 17 Prostanoic acid 420 22 Prostaphlin® (oxacillin) 50 17 Prostate glands 413 20 Prosympal 415 20 Protein 332 16 a-Protein 105 16 Protein, C-reaktives 376 16 Protein, Denaturantien 366 16 Protein, hydrophobes 430 16 Proteine 365,366,382 16 Proteine, oligomere 366 22 Proteine synthesis 361 16 Protein-Kinase 400 16 Protein-Praa1bumin-Komp1ex 376 17 Proteins 64,81 21 Proteins 365 16 Proteins (pre-early) 430 16 Prothidium bromide 99 16 Protocollagen-Prolin-Hydroxy1ase 406 16 Pro top lasts 329 17 Protostrongylus rufescens 178 23 Protozoal vaccines IS 18 Protriptyline 457 16 Provera® (medroxyprogesterone ace­

tate) 92 22 Provera® (medroxyprogesterone ace­

tate) 73

Index Vol. 16-23

22 Pro-Viron® (mestero1one) 69,70 23 Pruritus 31 16 Pseudocholin-Esterase 440 16 Pseudomonas aeruginosa 310 19 Pseudomonas aeruginosa 546 23 Pseudomonas aeruginosa 14 19 Pseudomonas enteritidis 587 16 Pseudomonas oleovorans 231,249 20 Psychopharmaceutical agents 389 18 Pteridine 299 21 Pulmonary embolism 315 16 Purified protein derivative (PPD) 102 16 Purine analogs 93,94 22 Purinetho1® (mercaptopurine) 64 16 Purinnudeosid-Phosphory1ase 394 17 Purkinje fibers 36 16 Puromycin 89, 90 16 Pyocyanase 310 22 Pyopen ® (carbenicillin) 51 20 Pyramidon® (aminophenazone) 401 22 Pyran 272 16 Pyrante1 (Banminth®, Combantrin®, Stron-

gid®) 158, 164, 165, 167 17 - 124,155,160,165,172 18 - 158, 164, 167 19 - 33,36,40 20 - 451 22 - 48 18 Pyrazinamide (Tebrazid®) 212 22 - 36 21 Pyrazinopyridoindoies 455 22 Pyrazo1o-1,4-benzodiazepinones 257 21 Pyrazoio[3,4-b]pyridines 91 22 Pyrazo1o[3,4-b]quinolines 275 20 Pyribenzamine® (tripelennamine) 426 22 Pyrido-1,4-diazepinones 255 21 Pyridopyrazines 88 21 Pyrido[2,3-b]pyrazines 78 21 Pyridopyrimidines 83 21 Pyrido[2,3-d ]pyrimidines 69 21 Pyrido[3,2-d ]pyrimidines 69 16 Pyridoxal-5' -phosphate 222 16 Pyridoxal-phosphate-y-glutamylhydra­

zone 223 16 Pyridoxaminpyruvat-Aminotrans-

ferase 402 22 Pyridoxine (vitamin B6) 86 18 Pyrimethamine (Daraprim®) 107, 328 20 - 336,435 22 - 44 16 Pyrimidines analogs 97 20 Pyrimidone (Mysoline®) 387 21 Pyrimidopyridazine derivates 89 21 Pyrogallol 191 16 Pyrophosphatase, anorganische 390, 398 16 Pyruvat-Carboxy1ase 418 16 Pyruvat-Decarboxylase 404 16 Pyruvat-Dehydrogenase 406,410,418 16 Pyruvat-Dehydrogenasekomp1ex 420 16 Pyruvat-Kinase 402,408,438 17 Pyrvinium (Povan®) 127,170,173 19 - 152

Index Vol. 16-23

20 Pyrvinium (Povan4D) 452 22 - 48

Q 23 Quantitative structure activity relationships

(QSAR) 98, 200 20 Questran4D (cholestyramine) 418 16 Quinacrine (Atabrine4D, Atebrin4D, Acri-

chine4D, mepacrine) 100 17 - 119,148,152,294 18 - 325 20 - 441 21 - 343 22 - 38 22 Quinapyramine (Antrycide4D) 42 18 Quinaspar 116 22 Quinazoline 3-oxides 233 21 Quinestrol 302 20 Quinethazone 210 21 Quingestanol acetate 302 17 Quinidine 24,36,51 20 Quinidine 406 17 Quinine 24 20 Quinine 435 22 Quinine 40 21 Quinoline derivates 12 17 Quinolinemethanols 270 20 3-Quinuclidinyl benzilate 335 22 Quinuronium sulfate (Acaprin4D) 42

R 21 R2323 (l3-ethyl-17-hydroxy-18,19-dinor-

17a-pregn-4,9,II-trien-20-yn-3-one) 308, 322,350

22 R34000 11 0 16 Rabbit antilymphocyte fraction serum

(RALfS) 103 18 Rabies 240 18 Rabies virus 240 16 Radiation 79 16 Rafoxanide (Flukanide®, Novazole®,

Ranide®) 172 17 - 115,135,165,272,282,283,298 17 Raillietina cesticillus 294, 299 17 Raillietina echinobothrida 294 17 Raillietina tetragona 294 16 RALfS (rabbit antilymphocyte fraction

serum) 103 17 Rametin® (naphthalophos) 129 22 Ramihyphin A 132 17 Ranide® (rafoxanide) 282 17 Ranestol® (triclofenol, piperazine) 127 22 Rapamycin 131 22 Rastinon® (tolbutamide) 80 17 RD 12,869 (6-chloro-5-{[2-(diethylami-

no)ethyl]amino}-8-methy1quinoline) 254 20 Reagin 589 20 Receptor research 342 21 Receptor-site models 117 16 Red blood cell (RBC) 88

17 Red blood cell (human) 60 17 Red blood cell (trout) 61 17 Red blood cell, diffusion in 61 17 Red blood cell, geometry of 91 17 Red blood cell membrane 60,87 17 Red blood cell membrane, chemical

composition of 76 17 Red blood cell membrane,

permeability of 64 17 Red blood cell, transport in 61 22 Redul® (glymidine) 81 16 Refsum's disease 285 20 Regitine® (phentolamin~) 413 19 Rehydration therapy 527 16 Renal abscess 322 20 Renal transplantation 584 20 Renese® (polythiazide) 417 20 Renin-angiotensin system 245 16 RES (reticuloendothelial system) 73, 101 20 Rescinnamine 208 20 Research institutes 20 16 Reserpine (Serpasil®) 91,220,345,346,

349 17 - 75 19 - 149 20 - 206,389,407 21 - 199 22 - 368 20 Reserpine, mode of action 207 17 Resorantel (4'-bromo-y-resorcylanilide;

Resorcylamin, Terenol®) 120, 139, lSI, 154,284,298

17 Resorcinol 74

275

17 Resorcylamin® (resorantel) 120 20 Respiratory tract, infeCtion of 361, 363 20 Resyl® (guaiphenesin) 392 16 Reticuloendothelial system (RES) 73, 101 17 Reticulum, endoplasmic 488 22 Retinol (vitamin A) 84 21 Retroprogestogen 321 22 Reverin® (politetracycline) 53 16 Rezeptorprotein, cholinerg. 380 20 Rheumatic diseases 362 20 Rheumatoid arthritis 362 22 Rhodanine 289 16 /-Rhodinic acid 242,243 22 Ribavirin (Virazole®) 61,278,290 22 Riboflavine (vitamin B:z) 86 17 1-P-D-Ribofuranosyl-4-hydroxy-3,4,5,6-

tetrahydro-2(lH)-pyrimidinone 332 17 1-P-D-Ribofuranosylpyrazolo[3,4-d]pyrimi-

dine-4(5H)-one 343 16 Ribonucleic acid (RNA) 215 16 Ribonucleotid-Diphosphat-Reductase 410 16 Ribosomale Proteine 432 16 Ribu1ose-Diphosphat 442 16 Ribulose 1,5-diphosphat-Carboxy1ase 416,

418 16 L-Ribu1ose-Kinase 394 23 Ricinoleic acid 71 22 Rifaldin® (rifampicin) 59

276

18 Rifampicin (Rifaldin®, Rimactan®) 212, 324

22 - 59,133 21 Rifampin 131,176 22 Rifampin 311 22 Rifamycin 59 22 Rimactan® (rifampicin) 59 22 Rimantadine 277,302 22 Rimifon® (isoniazid) 34 19 Rinderpest 274 19 Ringer injection 511 22 Ripazepam (CI-683) 257 17 Ripercol® (tetramisole) 125 16 Ristocetin 313 19 Risus sardonicus 202,216 20 Ritalin® (methylphenidate) 397 18 RL-712 310 16 RNA (ribonucleic acid) 215 16 RNA-Polymerase 388,414,416,418,440 18 RNA-Polymerase 253 20 Robinul® (glycopyrrolate) 420 17 Rodameb® (diphetarsone) 123 19 Rodameb® (diphetarsone) 36 22 Rohypnol® (fiunitrazepam) 262 22 Rolitetracycline (Reverin®) 53 17 Ronnel (fenchlorphos, Ectoral®, Trole-

ne®) 128 19 p-Rosani1ine 150 17 Rosapin® (desaspidin) 120 23 Rottlerin 71 16 Roundworm 2, 158, 160, 170 18 Roundworm 191 17 R.P. 14015 (trans-I,4-di[(2-isothiocyana-

to )ethyl]cyclohexane) 300 19 Rubella 280 16 Rubidomycin 91 16 Rubredoxin 249,250 16 Rubredoxin reductase 249 16 Rue1ene 168

S 20 Salbutamol (Ventolin®) 419 17 Salicylaldehyde 306 22 Salicylamide 129 20 Salicylic acid 400 22 Salicylic acid 130 23 Salicylic acid 179 19 Saline loss 528 19 Salk vaccine 276 17 Salmo gairdnerii 293 19 Salmonella typhimurium 546 19 Salmonellosis 570 17 Salmo trutta L. 79 22 Salvarsan® (arsphenamine) 37 20 Sandomigran® (pizotifen) 426 20 Sandostene® (thenalidine) 426 20 Sanorex® (mazindol) 420 19 Santonin 149 17 Saponin 81,94 20 Saralasin 246

Index Vol. 16-23

22 Saramycetin 125 23 Sarcina lutea 180 20 Saturation metabolism 526

19 Schick test 339 17 Schistosoma intercalatum 139, 147 16 Schistosoma mansoni 12,22, 39, 49 17 Schistosoma mansoni 139,244 18 Schistosoma mansoni 15,200 20 Schistosoma mansoni 448 16 Schistosoma haematobium 12,22,49 17 Schistosoma haematobium 139,245 18 Schistosoma haematobium 15,200 20 Schistosoma haematobium 448 16 Schistosomajaponicum 12,23,60 17 Schistosomajaponicum 139,253 18 Schistosomajaponicum 15,200 19 Schistosomajaponicum 119 20 Schistosoma japonicum 448 17 Schistosoma mattheei 147,275 17 Schistosomiasis 139, 140,243 18 Schistosomiasis 15,44,280 19 Schistosomiasis 119 20 Schistosomiasis 448 20 Schizophrenia 38 18 Schwann cells 57

17 Scolaban® (bunamidine) 121,302 16 Scopolamine 341,351 22 Scopolamine 368 20 Screening II 16 SDS (Na-Dodecylsulfat) 366 19 Sea-fish 499 20 Sedormid® (apronalide) 387 20 Segontin® (prenylamine) 406 19 Senna 526 23 S-180 enzyme 61 22 Sepazon® (cloxazolam) 252 20 Septrim® (trimethoprim + sulphamethox-

azole) 438 19 Sera 179 22 Serax® (oxazepam) 242 20 Serenace® (haloperidol) 390 22 Serenal® (oxazolam) 252 20 Serenid® (oxazepam) 393 16 Serin-Dehydrase 390 16 Serin-Transacetylase 402 22 Seromycin® (cycloserine) 55 16 Serotonin (5-HT, 5-hydroxytrypt­

amine) 221,336,341 19 Serotonin (5-HT, 5-hydroxytrypt-

amine) 149 20 SerpasiJ® (reserpine) 407 19 Serum IgE 122 16 Seryl-tRNA-Synthetase 394,398 19 Sewage 571 19 Shigella flexneri 573, 574 19 Shigella sonnei 573 19 Siderophilin 551 19 Shigellosis 570 23 Shigellosis 13

Index Vol. 16-23

23 Shikimic acid 71 21 Silastic® capsules 305 21 Silastic 382® ring 307 21 Silicone 345 22 Silubin® (buformin) 80 22 Silymarin 312 20 Sinequan® (doxepin) 394 20 Singoserp® (syrosingopine) 408 17 Sinoatrial node 44 22 Sirodesmin A 310 18 Sisomicin 423 17 SKF 525-A (2-diethylaminoethyI2,2-

diphenylvalerate HCl) 13, 18, 27, 360, 372 17 SKF 2314 (2,2-diphenylvaleric acid) 18 17 SKF 8742-A (2-ethylaminoethyI2,2-diphe­

nylvalerate HBr) 24 22 SKF 23880 A (cylooctylamine hydrochlo-

ride) 27 20 Skin infection 361 19 Skin permeability 505 19 Skin test 120, 128 22 Sleep mechanisms 367 22 Sleep research 355 18 Smallpox 28,44,281 19 Smallpox 255,274 23 Smallpox 11 17 SN-IO,275 (6,8-dichloro-2-phenyl-a-(2-

piperidyl)-4-quinoJinemethanol) 270 22 Social pharmacology 11 16 Sodium 1_1"C acetate 282 17 Sodium antimonyl dimethylcysteine tar-

trate 112, 143, 146 20 Sodium antimony tartrate 449 22 Sodium arsanilate (Atoxyl®) 40 20 Sodium dipropylacetate (Depakine®) 424 16 Sodium fiuoracetate 343 17 Sodium ion transport 63 20 Sodium nitroprusside 232 16 Sodium salicylate 98 17 Sodium salicylate 75 18 Sodium stibogluconate (Pentostam®) 307 20 - 442 23 Solapalmitine 76 23 p-Solarmarine 86 17 Soidactonelll> (potassium canrenoate) 47 22 Soludactone® (potassium canrenoate) 76 20 Solustibosan® (sodium stibogluconate) 442 22 Solvoteben® (Tb IV) 34 23 Somatostatin 60 16 Somatotropes Hormon 374 20 Sotalol 34, 36, 225 17 Soybean Jipoxidase 435 21 Sparteine sulfate 374 19 Spatula Test 219 22 Spectinomycin (Trobicin®, Stanilo®) 56 21 Sperm antigens 366 21 Spermatogenesis 347 21 Sperm enzymes 366 21 Sperm maturation 354 21 Sperm transport 312,356,375 16 Spheroplasts 329

17 Sphingomye1ins 72, 78 17 Spirocerca lupi 171 17 Spirometra mansonoides 148,303 20 Spironolactone (Aldactone®) 213 22 - 76 18 Spiroperidol 437 21 Spiroperidol 415 21 Spontaneous drug monitoring 254 17 SQ 18506 (trans-5-amino-3-[2-(5-nitro-2-

furyl)vinyl]-1,2,4-oxadiazole) 264,267

22 Stanilolll> (spectinomycin) 56 22 Stanozol (Winstrol®) 69 22 Stapenorlll> (oxacillin) 50 22 Staphcillinlll> (methicillin) 50, 51 16 Staphylococcal infection 319 16 Staphylococci epitkrmidis 316 16 Staphylococcus aureus 311,313 17 Staphylococcus aureus 223,234 16 Staphylococcus staphylolyticus 310, 328 16 Staphylolytic activity 313 22 Statolon 272 17 Stearic acid 435 21 Stelazine® 357 17 Stephanofilaria assamensis 183 17 Stephanofilariasis 183 20 Stereoisomerism 103 20 Stereoisomers, biological activities of 104 20 Stereoselectivity data 114 20 Stereoselectivity data, results 115 20 Stereospecificity 12 23 Steric parameters 207 20 Steroid hormones 296, 298 21 Steroidal contraceptives 298 20 Steroid hormones, effects on biosynthe-

sis 297 20 Steroid receptors 300 18 Steroids 429 18 Stibacetin 306,311 18 Stibamine 311

277

17 Stibocaptate (antimony dimercaptosucci­nate Astiban®, TWSb/6) 112, 140, 143, 182

22 - 47 17 Stibophen (Antimosan®, Corystibin®, Fua-

dinS) 112, 132, 144, 147, 183 19 - 155 22 - 47 17 Stibunal® (antimony sodium tartrate) III 20 Stiburealll> (urea stibamine) 442 18 Stilbamidine 301,319 17 Stilbazium iodide (MonoparGD) 124, 171,

174 21 Stilboestrol 310, 323 1'1 Stilesia globipunctata 154, 294 17 Stomach 459 22 Stoxil® (idoxuridine) 61 18 Streptococcusfaecalis 114 23 Streptococcus mutans 29 16 Streptokinase 326 16 Streptolysin S 112

278

17 Streptomyces achromogenes 368 16 Streptomyces antibioticus 299 17 Streptomyces aureofaciens 211 17 Streptomyces coeruleorubidus 373 16 Streptomyces griseus 282 17 Streptomyces michiganensis 302 17 Streptomyces noboritoensis 302 18 Streptomyces nodosus 320 18 Streptomyces noursei 322 17 Streptomyces peucetius 373 17 Streptomyces rimosus 212 16 Streptomycin 90 18 Streptomycin 212 22 Streptomycin 56 17 Streptozotocin 368 20 Streptozotocin 480 17 Strongyloides papil/osus 169 16 Strongyloides stercoralis 160, 165 17 Strongyloides stercoralis 169 18 Strongyloides stercoralis 199 19 Strongyloides stercoralis 18,29,41,42 20 Strongyloides stercoralis 454 17 Strongyloides westeri 170 17 Strongyloidiasis 169 19 Strongyloidiasis 18,42 20 Strongyloidiasis 454 23 Structure activity 170 16 Strychnine 349 20 Stutgeronllll (cinnarizine) 426 17 Styrydllll (styrylpyridinium) 124 16 Styrylpyridinium (Styrydllll) 173 17 - 124, 160

17 SU-4885 (metyrapone,2-methyl-l,2-bis-[3-pyridyl]-I-propanone) 15

20 Suavitilllll (benact"jZine) 392 17 Suberic acid, monomethyl ester of 416 22 Sublimazellll (fentanyl) 185 23 Substructure 99, 134 20 Subtilisin substrates III 16 Subunit-Bindungstypen 368 16 Subunits 365 16 Succinat-Dehydrogenase 396 19 Succindehydrogenase 308,319 17 Succinic acid 415 19 Succinic acid 286 21 Succinylcholine 113 16 Succinyl Co-A-Synthetase 402 23 Sucrose 28 17 Sugar phosphate 62 23 Sugar infusions 28 23 Sugar polymers 27 23 Sugar polymers, adverse reaction 27 23 Sugar polymers, anaphylactoid reac-

tions 30 23 Sugar polymers resistance 46 22 Sulfacetamide (Albucidllll) 31 20 Sulfadiazine (Debenalllll) 436, 437 22 - 31 22 Sulfadimethoxine (Madribonllll) 31 22 Sulfadimidine 43

Index Vol. 16-23

20 Sulfadoxine (sulformethoxine, Fana-Silllll) 436

22 - 31 22 Sulfaethidole (Globucidllll) 34 20 Sulfalene (sulphamethoxypyrazine, Kelfizi-

nallll) 436 22 - 31 22 Sulfamethoxazole (Gantanolllll) 31 22 Sulfamethoxydiazine (Durenatllll) 31 22 Sulfamethoxypyridazine (Lederkynllll,

Midicelllll) 31 22 Sulfametrole 33 16 Sulfanilamide (4-aminobenzenesulfon­

amide) 259 18 Sulfanilamide (4-aminobenzenesulfon­

amide) 330 20 Sulfanilamide (4-aminobenzenesulfon­

amide) 415 21 Sulfanilamide (4-aminobenzenesulfon-

amide) 31 22 Sulfaphenazole (Orisulllll) 31 21 Sulfathiazole (Cibazolllll) 31 20 Sulfinpyrazone (Anturanllll) 401,402 21 Sulfisoxazole (Gantrisinllll) 31, 129 16 Sulfit-Oxidase 396 20 Sulfonal 387 21 Sulfonamide 174 18 4',4"'-Sulfonylbisacetanilide (acedapsone,

Hansolarllll) 156 18 4,4'-Sulfonyldianiline (dapsone, diamino­

diphenyl sulfone) 108, 155 22 Sulformethoxine (sulfadoxine, Fana-

silllll) 31 17 Sulfuric acid 483 20 Sulindac (Clinorilllll) 402 20 Sulphadoxine (Fanasilllll) 436 20 Sulphamethoxypyrazine (Sulfalenellll) 436 17 Sulphaphenazole 26 17 2,2' -Sulphinylbis(4,6-dichlorophenol)

(Bitin S) 297 20 Sulpiride (Dogmatilllll) 391 16 Superoxid-Dismutase 388 17 Suramin sodium (Antrypolllll, Germaninllll ,

Moranylllll, Naganol l111) 132, 183 18 - 331 19 - 155 20 - 445 22 - 38 22 Surfen CIIII (congasine) 42 20 Suxamethonium (Anectinellll) 422 20 Symmetrelllll (amantadine) 423 22 Symmetrelllll (amantadine) 62,277 21 Sympathectomy 357 20 Sympatolllll (oxedrin) 411 22 Synalarllll (tluocinolone acetonide) 75 19 Synaptic apparatus 304 22 Synchroceptllll (prostalene) 84 17 Syngamiasis 177 17 Syngamus trachea 177 20 Synopenllll (chloropyramine) 426 22 Synthalin 44

Index Vol. 16-23

22 Synthalin A 79 20 Synthetic drugs 10 20 Synthetic products 144 20 Syntropan® (amprotropine) 420 17 Syphacia obvelata 296 19 Syphilis 281 23 Syphilis 20 22 Syraprim® (trimethoprim) 44 20 Syrosingopine (Singoserp®) 208, 408 16 Systox 355

T 16 Tabakmosaikvirus 384 17 TAC [pararosaniline; tris(p-aminophenyl)

carbonium] 118,255 20 Tachyarrhythmias 37 18 Tachycardia 393 . 19 Tachycardia 246 20 Tacitin® (benzoctamine) 393 17 Taenia hydatigena 153 17 Taenia ovis 153 17 Taenia pisifarmis 153,303 17 Taenia saginata 152 18 Taenia saginata 198 19 Taenia saginata 20, 137 20 Taenia saginata 447 17 Taenia serialis 300 17 Taenia solium 152, 292 18 Taenia solium 197 19 Taenia solium 20 20 Taenia solium 447 17 Taenia taeniae/ormis 303 19 Taenia taeniae/armis 54 17 Taeniasis 152 17 Talodex® (fenthion) 128 22 Talwin® (pentazocine) 160 16 «Tamm-Horsfall»-Glykoprotein 380 21 Tamoxifen 324 20 Tanderil® (oxyphenbutazone) 401 17 Tannic acid 70, 73 22 Tapazole® (methimazole) 77 16 Tapeworm 164 17 Tapeworm 154 18 Tapeworm 191 20 Tapeworm infections 447 20 Taractan® (chlorprothixen) 389 17 Tartar emetic (antimony potassium tar­

trate) 111 18 Tartar emetic (antimony potassium tar­

trate) 303 22 Tartar emetic (antimony potassium tar-

trate) 47 16 Taurocyanin-Kinase 392 20 Tavegyl® (clemastine) 424 23 Taxol 81 22 Tb VI (Solvoteben®) 34 16 TBZ (Thiabendazole) 158-160 22 Tebrazid® (pyrazinamide) 36 22 Tebrophen 302 22 Tegopen® (cloxacillin) 50 20 Tegretol® (carbamazepine) 394

17 Telmid® (dithiazanine) 127 17 Telmin® (mebendazole) 159 22 Temazepam (Levanxol®) 242,261 22 Temgesic® (buprenorphine) 156, 157 17 Tenebrio molitor 294 19 Teniasis 20 17 Tenoban® (nemura1) 121 17 Tenoban® (drocarbil) 121 20 Tenormide 227 20 Tenormin® (ateno101) 237,411 20 TEPA (triethy1enephosphoramide) 468 20 Terbutaline (Brethine®) 419 17 Tereno1® (resorante1) 120, 284 17 Ternidens diminutus 171 17 Teroxa1ene 250 22 Terramycin® (oxytetracycline) 53 17 Testosterone 24, 25, 75 20 Testosterone 475 22 Testosterone 68 21 Testosterone oenanthate 348 21 Testosterone propionate 348 22 Testosterone propionate 68 23 Tetandrine 86 19 Tetano1ysine 307 19 Tetanus 189,210,245,256,288,323,347,

356,439 23 Tetanus 11, 17 19 Tetanus antibodies 368 19 Tetanus antitoxin serum 315 19 Tetanus antitoxin therapy 398 19 Tetanus attacks 213 19 Tetanus clinical trials 372 19 Tetanus complications 202, 222 19 Tetanus death 203,223,439 19 Tetanus fever 197,216 19 Tetanus frequency 191 19 Tetanus immunization 281,314,358 19 Tetanus immunoglobulin 324 19 Tetanus incidence 190,210 19 Tetanus incubations 195,213 19 Tetanus infection 269,324 19 Tetanus injury 213 19 Tetanus intoxication 396 19 Tetanus investigations 314 19 Tetanus light effect 202,221 19 Tetanus mortality 191,440 19 Tetanus neonatorum 190 19 Tetanus nursing 382 19 Tetanus onset 197,215 19 Tetanus pathogenesis 301,306 19 Tetanus prevention 391 19 Tetanus prognosis 214 19 Tetanus prophylaxis 378 19 Tetanus recurrence 223 19 Tetanus relapse 223 19 Tetanus rigidity 200, 220 19 Tetanus severity 191 19 Tetanus sex incidence 192 19 Tetanus situation 368 19 Tetanus spasms 198,217 19 Tetanus symptoms 214

279

280

19 Tetanus, therapeutic measurement 323 19 Tetanus therapy 204,224,315 19 Tetanus toxaemia 250 19 Tetanus toxin 301,316, 329, 384, 387 19 Tetanus treatment 378 19 Tetanus vaccination 396 19 Tetanus vaccines 229 16 Tetrabenazine 345 17 3,3',5,5'-Tetrabromo-2,2'-biphenyldiol

mono (dihydrogen phosphate) (bromofen­fos, Acedist®, Ph 1882) 113, 134, 278

17 Tetracaine 75 17 Tetracap® (tetrachlorethylene) 130 17 Tetrachlorethylene (tetrachloroethylene,

Ankilostin®, Nema®, Tetracap®) 130, 138, 162

19 - 36,40,70,72,86,92, 103, 154 20 - 451 22 - 46 17 N-[I, 1,2,2-Tetrachloro-2-fluoroethyl)­

thio )alkanesulphonanilides 308 17 4,5,6,7-Tetrachloro-2-(trifluoromethyl)-

benzimidazole 291 16 Tetracosanoic acid 284 17 Tetracycline (Achromycin®) 211,216 18 - 361 19 - 510,519,539,568 20 - 436,440 21 - 170 22 - 53, 132 17 14C_ Tetracycline 230 17 Tetracyclines activities 223 17 Tetracyclines biology 234 17 Tetracyclines biosynthesis 230 17 Tetracyclines isolation 229 17 Tetracyclines manufacture 228 17 Tetracyclines purification 229 17 Tetracyclines semisynthetic modifica-

tions 213 17 Tetracyclines total synthesis 222 16 Tetradecanoic acid 244,267 23 Tetradecanoyl phorbol acetate (TPA) 72 16 Tetraethylammonium 213 20 Tetraethylammonium chloride 200, 409 20 1,2,4,5-Tetrahydro-3H,3-benzazepines 72 18 5,6,7,8-Tetrahydrobiopterin 300 16 LJ8_ Tetrahydrocannabinol 224 16 LJ9_ Tetrahydrocannabinol 224 20 Tetrahydrofolic acid 471 17 L( - )-Tetrahydrofolic acid 324 16 p-Tetrahydronaphthylamine 337 16 Tetrahydroquinolines 58 17 Tetrahydro-2H-I,3,5-thiadiazine-2-

thiones 290 17 Tetrahydrothiophene-3-o1 I, I-dioxide 366 17 Tetrahydrouridine 333 16 2,2,17,17-Tetramethyloctadecane-I, 18-

dioic acid 237 16 2,2,17, 17-Tetramethyloctadecanoic

acid 237 16 Tetramisole (Ascarotrat®, Nilverm®,

Ripercol®) 158, 161, 162

Index Vol. 16-23

17 - 125,155,159, 160, 163-165, 169, 171, 174, 176-178

19 - 33, 141, 166 20 - 349,354 22 - 49 16 I-Tetramisole (levamisole) 166 17 1-Tetramisole (levamisole) 125 19 1-Tetramisole (levamisole) 166 20 I-Tetramisole (levamisole) 349,354 17 Tetranorprostaglandin BI 452 17 Tetranorprostaglandin EI 452 17 Tetranor-prostan-I,16-dioic acid 420 22 Tetrazepam (Myolastan®) 250 17 Tetrodotoxin 41 22 Thalamontal® (fentanyl + droperidol) 185 16 Thalidomide 99 21 Thalidomide 199,242 17 Thaurocholate 94 20 Thebaine 51,53 22 Thebaine 151 20 Thelazia 350 17 Thelazia gulosa 171 17 Thelazia rhodesi 171 17 Thelmesan® (dymanthine) 131 19 Thelmesan® (dymanthine) 103 20 Thenaldine (Sandosten®) 426 17 Theniathane® (dichlorophene) 121 17 Thenium (Ancaris®, Bancaris®, Cano-

par®) 130, 162 20 Tenormin® (atenolol) 411 16 2-(2-Thenyithio)-2-imidazoline 166 19 Theophylline 521 20 Thephorin® (penindamine) 426 20 Therapeutic activity 14 20 Therapeutic trials lSI 20 Therapy fractionation 534 16 Thetin-Homocystein-Methylferase 404 17 Thiaben® (thiabendazole) 125 16 Thiabendazole (Lombristop®, Mintezol®,

Thiaben®) 158-160 17 - 125, 133, 156, 159, 160, 163, 164, 166,

169,172,174,176,177, 179, 184, 185 18 - 199,202 19 - 33,36,41,42,152,166 20 - 452 22 - 49, 109, 119 17 Thiacetarsamide (arsenamide, Caparside®,

Caparsolate®) 122 18 Thiacetazone (Conteben®) 212 22 - 34 22 Thiambutosine (CIBA 1906®) 36 20 Thiamenidine 223 22 Thiamine (vitamin BI) 86 23 Thiamine (vitamin BI) 51 22 Thiamphenicol (Glitisol®) 54 22 Thiamycin 53 23 Thiamycin 54 17 S-2-{[2-(2-Thiazolylcarbamoyl)-ethyl)ami-

no}ethyl hydrogen thiosulphate 266 16 Thiazothielite 163, 164 16 Thiazothienol 163 22 Thieno-I,4-benzodiazepinones 256

Index Vol. 16-23

21 Thieno[2,3-b]pyridines 90 16 P-2-Thienyl-alanine 88 16 2-[2-(2-Thienyl)ethyl]-2-imidazoline 166 23 Thin-layer chromatography 122 17 2,2'-Thio bis( 4, 6-dichlorophenol) (bithio­

nol) 278 17 Thio-3,5-bis(trifiuoromethyl) carbani-

lides 307 22 Thiocarlide (Isoxyl®) 36 16 Thiocymetin 118 16 Thiogalaktosid-Transacetylase 390 16 6-Thioguanine (6-TG) 75,94 17 6-Thioguanine (6-TG) 336,341,342 20 6-Thioguanine (6-TG) 473 17 6-Thioguanylic acid 341 17 6-Thioinosine 339, 342 17 6-Thioinosinic acid 337, 340 20 Thiopental (Pentothal®) 387 21 - 109 16 Thioproperazine 346 16 Thioredoxin-Reductase 390 20 Thioridazine (Melleri1®) 389 21 - 357,413 16 Thiosemicarbazide 220 22 Thiosemicarbazones 284 17 Thiosinamine (allylthiourea) 274 16 Thiosulfat-Sulfurtransferase 388 16 Thio-TEPA [triethylenethiophosphor­

amide, tris(l-aziridinyl)phosphine sulfide] 118

17 Thio-TEPA [triethylenethiophosphor­amide, tris(1-aziridinyl)phosphine sulfide] 363

20 Thio-TEPA [triethylenethiophosphor­amide, tris(l-aziridinyl)phosphine sulfide] 468

22 Thio-TEPA [triethylenethiophosphor­amide, tris(1-aziridinyl)phosphine sulfide] 64

22 Thiourea 77 176-Thiouric acid 340 21 cis-Thioxanthene 417 21 Thioxanthene derivatives 441 16 Thioxanthenones 40-46 17 6-Thioxanthine 339 17 6-Thioxanthylic acid 339 16 Threonin-Dehydratase 402,404 16 Thrombin 388 21 Thrombo-embolism 244 17 Thrombosis, prevention of 466 17 Thyasanieza ovilla 297 16 Thymectomy 78 16 Thymidylat-Synthetase 390 20 Thymidylic acid 471 22 Thymol 128 16 Thymostatin 112 22 Thymoxamine 368 20 Thymoxyethyl-diethylamine 424 16 Thyreoglobulin 382 16 Thyreotropes Hormon 374 23 L-Thyronine derivatives 147

281

23 Thyrotropin releasing hormone (TRH) 58, 59

19 Thyroxine 267 22 Thyroxine 77 23 Thyroxine 38 17 Thysanosoma actinioides 154 20 Tienilic acid 244, 417 17 Tiguvon® (fenthion) 128 22 Tilidine 207 22 Tilorone 63 20 Timolol (Blocadren®) 34,36,226,229,230,

411 22 Tinactin® (tolnaftate) 36 20 Tinidazole (Fasigyne®) 438 22 - 46 20 Tiprenolol 33, 227 21 Tissues regitries 255 17 Tixantone® (lucanthone) 115 22 Tobramycin (Nebcin®) 56 22 a-Tocopherol (vitamin E) 86 19 Toes, hyperfiexion of 221 20 Tofranil® (imipramine) 394 20 Tolamolol 34, 36, 229 22 Tolazamide (Tolinase®) 81 20 Tolazoline (Priscol®) 220, 413 22 Tolbutamide (Rastinon®, Orinase®) 80 23 - 38 17 Tolene® (ronnel) 128 22 Tolinase® (tolazamide) 81 20 Toliprolol 226 22 Tolnaftate (Tinactin®) 36, 126 22 Topisolon® (desoxymethasone) 74 16 Torulopsis apicola 266,274 16 Torulopsis gropengiesseri 265,270,275 16 Torulopsis magnolia 264 19 Toxaemia 416 17 Toxascaris canis 156 17 Toxascaris leonina 156 21 Toxic dose 132 21 Toxicity 126, 163, 192 21 Toxicity dose dependency 140,200 20 Toxicity test 18 16 Toxicology 199 20 Toxicology 146

.21 Toxicology 124, 163 19 Toxin 249 19 Toxin activation 566 19 Toxin binding 566 19 Toxin elaboration 565 16 Toxin A 376 16 Toxin B 376 17 Toxocara canis 184 20 Toxocara canis 455 17 Toxocara cati 184 19 Toxocara cati 54 20 Toxocara infection 354 19 Toxoid lot No.OOIOI 544 19 Toxoid preparations 265 23 Toxoids II 18 Toxoplasma gondii 205 20 Toxoplasma gondii 437

282

18 Toxoplasmosis, diagnosis of 210 16 TPN +-Isocitrat-Dehydrogenase 394 16 TPNH-Cytochrom-C-Reductase 392 22 Trace® (chlorotrianisene) 72 19 Tracheostomy 246, 298 16 Transaldolase 390 16 Transcarboxylase 418 19 Transferrin 110,551 16 Transketolase 400 22 Tranxene® (clorazepate) 245 20 Tranylcypromine (Pamate®) 396 20 Trasentine® (adiphenine) 420 20 Trasicor® (oxprenolol) 411 16 Trasylol 112 20 Trausabun® (melitracen) 394 22 Trecator-SC® (ethionamide) 36 17 Trematodes III 17 Tremerad® (clioxanide) 114,281 16 Tremor 342 20 Tremor 38 16 Tremorine 350 22 Trenimon® (triaziquone) 64 18 Treptonematosis 280 23 TRH (thyrotropin releasing hormone) 58,

59 22 Triamcinolone (Aristocort®, Kenacort®,

Ledercort®) 75 18 2,4,6-Triaminoquinazolines 116 20 Triamterene (Dyrenium®) 213,417 20 Triazenoimidazoles 469 22 Triazino[5,6-bJindoles 285 22 Triaziquone (Trenimon®) 64 20 Triazolam (Halicon®) 393 22 - 254,255,367 16 1,2,4-Triazole 278 22 Triazure® (azaribine) 64 21 Tribolium castaneum 179 17 3,4,5-Tribromosalicylamide 284 16 Tricaprin 234 16 Tricaprylin 234 17 Trichazol® (metronidazole) 125 17 Trichinelliasis 185 16 Trichinosis 160 20 Trichinosis 454 18 Trichinella spiralis 195 20 Trichinella spiralis 454 20 Trichlorethanol 387 20 Trichlormethiazide 210 18 I, 1,1-Trichloro-2,2-bis(p-chlorophenyl)

ethane (DDT) 248,267,284 18 Trichloroethane 376 17 I, I , I-Trichloroethane 16 17 I, 1,2-Trichloroethane 16 17 6,6'-(2,2,2-Trichloroethylidene)dithy­

mol 296 18 Trichloroftuoromethane 370 16 Trichlorofon (metrionate, trichlorophon,

Negaron®, Dipterex®) 168 17 - 128,143,158,164,170,171,175,183,268 22 - 47 20 Trichlorophen 447

Index Vol. 16-23

19 Trichlorophenol-piperazine 33 17 5-(2,4,5-Trichlorophenyl)-hydantoin 270 18 Trichlorotriftuoroethane 375 17 Trichomonas vaginalis 263 20 Trichomonas vaginalis 442 20 Trichomonal vaginitis 442 17 Trichostrongyliasis 164 18 Trichostrongylus 194 16 Trichostrongylus colubriformis 161 17 Trichostrongylus colubriformis 164 17 Trichuriasis 174 18 Trichuriasis 192 19 Trichuriasis 14,23,34, 170 20 Trichuriasis 452 20 Trichuris 355 17 Trichuris suis 174 16 Trichuris trichiuria 165 17 Trichuris trichiuria 174 18 Trichuris trichiuria 191 19 Trichuris trichiuria 15,29,34,81, 102, 106,

141,161 20 Trichuris trichiuria 452 16 Trichuris vulpis 173 17 Trichuris vulpis 174 17 Triclofenol piperazine (Ranestol®) 127,

161 22 Triclosan (lrgasan DP3OO®) 29 16 Tridecylen 234 23 Tridixethyl n-aikyisulfonates 118 17 Triethylenemelamine 361 20 Triethylenemelamine 468 22 Triethylenemelamine 64 16 Triethylen thio-phosphoramide (Thio-

TEPA) 118 17 Triftocin 67 22 Triftubazam 257 17 I, I, I-Triftuoro-2-chloro-2-bromoethane

(halothane) 16 22 Triftuorothymidine 295 17 Triftuperazine 75 18 Triftuperidol 437 17 Triglyceride lipase 467 17 9a, Ila, 15-Trihydroxyprost-5-enoic

acid 453 17 2-(2,4,6-Triiodophenoxy)butyric acid

(phenobutiodil, Trijobil®) 299 22 Triiodoresorcinol 302 19 Triiodothyronine 245 22 Triiodothyronine 77 23 Triiodothyronine 39 17 Trijobil [2-(2,4,6-triiodophenoxy)butyric

acid, phenobutiodilJ 299 16 Trilaurin 234 20 Trimazosin 234 20 Trimethaphan 202 20 Trimethaphan camsylate (Arfonad®) 409 20 Trimethidinium 202 16 Trimethoprim (Syraprim®) 91 18 - 108,116 20 - 435,436 22 - 31,44

Index Vol. 16-23

23 1,2,3-Trimethoxybenzene 108 23 2,2,3-Trimethylbutane 127 16 3,9,9-Trimethyldecanoic acid 287 21 Trimethylphosphate 189 16 Trinonylin 234 16 Triosephosphat-Isomerase 388 17 Triostam® (antimony sodium gluco-

nate) Ill, 140 20 Triparanol 418 23 Tripdiolide 83 20 Tripelennamine (Pyribenzamine®) 426 19 Triple Antigen Glaxo 231, 253 17 Tris(p-aminophenyl)carbonium 255 16 Triundecylen 234 22 Trobicin® (spectinomycin) 56 17 Trodax® (nitroxynil) 117,278 22 Tromantadine 279 17 Tropical diseases 110 18 Tropical medicine 35 18 Tropical medicine, teaching of 35 16 Tropocollagen 378 16 Tropomyosin B 376 22 Trypaflavine 38 19 Trypan blue 505 21 Trypan blue 38 22 Trypan red 38 18 Trypanomycin 331 18 Trypanosoma brucei 302 18 Trypanosoma cruzi 111,323 20 Trypanosoma cruzi 446 23 Trypanosoma cruzi 15 19 Trypanosoma equiperdum 519 18 Trypanosoma evansi 302 20 Trypanosoma gambiense 445 20 Trypanosoma rhodesiense 445 22 Tryparosan 38 22 Tryparsamide (Trypotanide®) 40 22 Trypotanide® (tryparsamide) 40 16 Trypsin 112,338 17 Trypsin 81 20 Trypsin 79,332 16 Tryptophan 221 21 Tryptophan 314 16 L-Tryptophan 341 22 L-Tryptophan 369 16 Tryptophanase 408 16 Tryptophan-Oxigenase 398 16 Tryptophan-Synthetase 394,400,402 16 Tryptophanyl-tRNA-Synthetase 396,434 17 Tubercidin 271 18 Tubercle bacillus 96,214 18 Tuberculin test 98 18 Tuberculosis 28,44,279 19 Tuberculosis 256 23 Tuberculosis 22 18 Tuberculosis control 93 18 Tuberculosis control programme 97 19 Tuberculosis vaccine 274 18 Tuberculosis therapy 212 20 Tubocurarin 335,421 21 Tubocurarin III

19 d-Tubocurarin 149,296 16 Tubulin 376,430 19 Tularemia 280 20 Tumor 357, 358, 526 20 Tumor overacidification 550 23 Tumor promoters 65 16 Turnip-yellow-Virus 384 17 TWSb/6 (stibocaptate) 112 18 Tylosin 422 23 Type-specific immunity 13 23 Typhoid 15 19 Typhoid vaccines 275,277 23 Typhoid vaccines 14 19 Tyramine 149 16 Tyrosin-Aminotransferase 398 16 Tyrosinase 398 21 Tyrosine 411 16 Tyrosine hydroxylase 337,344 21 Tyrosine hydroxylase 412 16 Tyrosinreste 367

U 23 Ubiquinone (conenzyme Q) 54 16 UDPgalaktose 4-Epimerase 392,410 16 UDPglucose-Pyrophosphorylase 414 17 UK 3883 (2-[(isopropylamino)methyl)-6-

methyl-7-nitro-l,2,3,4-tetrahydroquino­line) 253

17 UK 4271 (oxamniquine) 253 22 Ultandren® (floxymesterone) 69 17 Ultracentrifugation 493 22 Ultralan® (fluocortolone 21-caproate) 74 17 Ultramicroelectrodes 39 16 Ultrazentrifugenmethoden 272 17 Uncinaria stenocephala 163 16 Undecane-I, ll-dioic acid 233 22 Undecenoic acid 130 16 Undec-lO-enoic acid 240 22 Uracil Mustard 64 22 Urbanyl® (clobazam) 258 22 Urbason® (methylprednisolone) 74 17 Urea 71 16 Urease 416 18 Urea stibamine (Stiburea®) 310,314 20 - 442 21 Urinary tract infections 11 19 Urine retention 221 16 Urocanase 398 22 Urotropin® (methenamine) 29 20 Urticaria 589 23 L-U snic acid 83 17 Uterus 454

V 18 Vaccination 255,285 20 Vaccination 574 18 Vaccines 256 19 Vaccines 274 23 Vaccines I 1 19 Vaccines, field trials 481 19 Vaccines, problems 235

283

284

19 Vaccines, production 229 19 Vaccines, testing 233 17 Valinomycin 67 19 Valium® (diazepam) 439 20 Valium® (diazepam) 393,422 22 Valiumll (diazepam) 230,242 20 Vallene® 409 20 Valmidll (ethinamate) 387 17 Valynomycetin 69 16 Vancomycin 313,318 19 Vanillylmandelic acid 245 19 Varicella-zoster 281 20 Vasculat® (bamethan) 411 20 Vasodilators 232 20 Vasopressin 286 20 Vatensol11 (guanoclor) 410 19 Vegetative nervous system 305 21 Vein thrombosis 315 22 Velban® (vinblastine) 64 18 Velbanamine 413 22 Velosef4l> (cephradine) 53 23 Veneral disease 19 20 Ventolin® (salbutamol) 419 17 Verapamil (Isoptinll) 46,52 20 - 406 16 Veratrine 213 17 Veratrine 35,75 20 Vergolysen® (hexamethonium chlo-

ride) 409 18 Vermiculine 331 23 Vermiculine 78 22 Verminumll (parbendazole) 49 17 Vermiplex® (dichlorophene) 121 17 Vermitinll (phenothiazine) 131 20 Vermox® (mebendazole) 452 22 Vermox® (mebendazole) 49 23 Vemolepin 78 22 Versicolin 131 22 Verstranll (prazepam) 261 20 Veterinary drugs 17 17 Viaseptll (glycobiarsol) 123 22 Vibramycin® (doxycycline) 53 19 Vibrio alginolyticus 516 19 Vibrio cholerae 460,472,482,491,503,546,

612 19 Vibrio cholerae antigen 612 19 Vibrio cholerae genetic recombination 460 19 Vibrio cholerae hybrides 461 19 Vibrio cholerae identification 515 19 Vibrio cholerae Inaba antiserum 468 19 Vibrio cholerae Inaba vaccine 544 19 Vibrio cholerae Inaba 569B 504 19 Vibrio cholerae isolation 515,579 19 Vibrio cholerae phage types 583 19 Vibrio cholerae strains 461, 547, 581, 597,

600 19 Vibriocidal antibody 475,556, 560, 605 19 Vibriocidal antibody titer 608 19 Vibriocidal titers 543,605 19 Vibrio costicolus 516 19 Vibrio El Tor 461,466,504,507

Index Vol. 16-23

19 Vibrio excretion 598 19 Vibrio parahaemolyticus 490,516,586 19 Vibrio parahaemolyticus carriers 500 19 Vibrio parahaemolyticus identification 588 19 Vibrio parahaemolyticus isolation 587 19 Vibrio parahaemolyticus strains 588 19 Vibrios cholera binding 565 19 Vibriostatic drug 519 22 Vidarabine (Vira-A®) 61 20 Viloxazine (Vivalanll) 396 22 - 365 22 Viminol 205 16 Vinblastine (Velbanll) 85,86 17 - 380 18 - 414 20 - 473,585 22 - 64 20 Vinca alkaloids 473 18 Vincoridine 409 16 Vincristine (Oncovinll) 85 17 - 370,380 18 - 413 20 - 473 22 - 64 18 Vindorosine 411 18 Vinkaleukoblastine 412 18 Vinrosamine 413 18 Vinyl chloride 389 22 Viocin® (viomycin) 59 22 Vioform® (clioquinol) 42 18 Viomycin (Viocinll, Vionactan®) 212 22 - 59 22 Vionactan® (viomycin) 59 22 Vira-A® (vidarabine) 61 20 Viral infection 355 22 Virazolell (ribavirin) 61,290 22 Virazole analogues 291 19 Virulence test 547 22 Virus diseases 268 20 Visceral larval migrans 455 20 Visceral Leishmaniasis (Kala Azar) 442 19 Visceral organs 306 20 Visken® (pindolol) 36,411 17 Vitamin A (retinol) 75 22 Vitamin A (retinol) 84 20 Vitamin A glucuronide 566 22 Vitamin BI (thiamine) 86 18 Vitamin B2 (riboflavine) 431 22 Vitamin B2 (riboflavine) 86 22 Vitamin B6 (pyridoxine) 86 19 Vitamin BI2 108,330 22 Vitamin C (ascorbic acid) 84,85 22 Vitamin D 84 22 Vitamin D3 (cholecalciferol) 86 23 Vitamin BI2 51 22 Vitamin E (a-tocopherol) 86 22 Vitamin H (biotin) 86 22 Vitamin K 86 22 Vitamin KI (phylloquinone) 85 18 Vitamins 431 23 Vitamins 51

Index Vol. 16-23

20 Vivalan® (viloxazine) 396 20 Voltaren® (diclofenac sodium) 401

W 16 Wachstumsfaktor, epidermaler 376 17 Warfarin (Coumadin®) 495 20 - 404 21 - 117 19 Water examination 583 19 Waterloss 530 19 Water supply 571 16 Weinsiiure-Dehydratase 400 16 Whipvvorm 160, 163 18 Whipvvorm 191 19 Whipvvorm 170 19 Whole celIe lysate toxin 472 19 Whooping cough 179, 256, 343, 348 23 Whooping cough 12 19 Whooping cough incidence 258 19 Whooping cough morbidity 258 19 Whooping cough mortality 258 21 WIN 18446 [N,N1-bis(dichloracetyl)-1,8-

octanediamine) 352 22 Winstrol® (stanozol) 69 23 Withaferin A 85 16 Worm diseases 159 19 Worm-infestation 136 17 Worm Guard® (parbnedazole) 159 18 WR-81,844 (1-(3,4-dichlorophenyl)-3-{4-

[( l-ethyl-3-piperidyl)amino )-6-methyl-2-pyrimidinyl}guanidine 140

18 WR-135,403 (2,4-diamino-6-[(p-chlorophe-nyl)thio)quinazoline) 129

20 WR 142.490 (metloquine) 437 22 WR 142.490 (metloquine) 42 18 WR-158,122 [2,4-diamino-6-(2-naphthyl­

sulfonyl)quinazoline) 130 17 Wuchereria bancrofti 180

18 Wuchereria bancrofti 142, 174,201,260, 271

20 Wuchereria bancrofti 455

X 17 Xenobiotic detoxification 488 16 X-Irradiation 79 20 Xipamide 244 16 X-Rays 103 17 X-Rays 74 20 Xylazine 223 23 p-Xylene 133 17 Xylocaine® (lidocaine) 75 20 Xylocaine® (lidocaine) 403 17 9-P-o-Xylofuranosyladenine 346 17 9-p-n-Xylofuranosylhypoxanthine 346 20 Xylometazoline (Otrivine®) 420 19 n-Xylose 46, III 23 n-Xylose 40

Y 22 Yatren® (chiniofon) 42 18 Yavv 44 16 Yeast 264 19 Yellovv fever vaccine 274 17 Yomesan® (niclosamide) ll9,297 20 Yomesanill (niclosamide) 447 22 Yomesan® (niclosamide) 46

Z 17 Zanilill (oxyclozanide) 1I5,281 22 Zepbiran chlorideill (benzalkonium chlo-

ride) 29 16 Zinc 339 19 Zirconyl chloride 568 21 Zona pelludica antigens 368 17 Zoxazolamine 23 20 Zylopriro® (allopurinol) 402

285

Subject Index Sachverzeichnis Table des matieres

Vol. 1-23 (1959-1979)

Acetylen-Verbindungen als Arzneistoffe, Androgenic-anabolic steroids and naturliche und synthetische glucocorticoids, interactions

14,387 (1970) 14, 139 (1970) p-Adrenergic blocking agents Anthelmintic action, mechanisms of

20,27 (1976) 19, 147(1975)

287

p-Adrenergic blocking agents, Anthelminticaforschung, neuere Aspekte pharmacology and structure-activity 1,243 (1959)

10,46 (1966) Anthelmintics, comparative efficacy p-Adrenergic blocking drugs, 19, 166 (1975) pharmacology Anthelmintics, laboratory methods in the

15, 103 (1971) screening of Adverse reactions of sugar polymers in 19, 48 (1975) animals and man Anthelmintics, structure-activity

23,27 (1979) 3, 75 (1961) Allergy, pharmacological approach Anthelmintics, human and veterinary

3,409 (1961) 17, llO (1973) Amebic disease, pathogenesis of Antiarrhythmic compounds

18,225 (1974) 12,292 (1968) Amidinstruktur in der Antiarrhythmic drugs, recent advances in Arzneistofforschung electrophysiology of

11,356 (1968) 17,34 (1973) Amino- und Nitroderivate (aromatische), Antibacterial agents of the nalidixic acid biologische Oxydation und Reduktion type

8, 195 (1965) 21,9(1977) Aminonucleosid-Nephrose Antibiotics, structure and biogenesis

7,341 (1964) 2,591 (1960) Amoebiasis, chemotherapy Antibiotika, krebswirksame

8, 11 (1965) 3,451 (1961) Amoebiasis, surgical Antibody titres, relationship to resistance

18,77 (1974) to experimental human infection Amoebicidal drugs, comparative 19,542 (1975) evaluation of Anticancer agents, metabolism of

18,353 (1974) 17,320 (1973) Anabolic steroids Antifertility substances, development

2, 71 (1960) 7, 133 (1964) Analgesia and addiction Anti-filariasis campaign: its history and

5, 155 (1963) future prospects Analgesics and their antagonists 18,259 (1974)

22, 149 (1978) Antifungal agents Ancylostomiasis in children, trial of 22,93 (1978) bitoscanate Antihypertensive agents

19,2(1975) 4,295 (1962), 13, lOl (1969)

288

Antihypertensive agents 20, 197 (1976)

Antiinflammatory agents, nonsteroid 10, 139 (1966)

Antiinflammatory drugs, biochemical and pharmacological properties

8,321 (1965) Antikoagulantien, orale

11,226 (1968) Antimetabolites, revolution in pharmacology

2, 613 (1960) Antituberculous compounds with special reference to the effect of combined treatment, experimental evaluation of

18, 2II (1974) Antiviral agents

22,267 (1978) Art and science of contemporary drug development

16, 194 (1972) Arzneimittel, neue

1,531 (1959),2,251 (1960), 3, 369 (1961),6,347 (1963),10,360 (1966)

Arzneimittel, Wert urid Bewertung 10, 90 (1966)

Arzneimittelwirkung, Eintluss der Formgebung

10,204 (1966) Arzneimittelwirkung, galenische Formgebung

14,269 (1970) Atherosclerosis, cholesterol and its relation to

1, 127 (1959) Ayurvedic medicine

15, II (1971)

Index Vol. 1-23

Bitoscanate, clinical experience 19, 96 (1975)

Bitoscanate, experience in the treatment of adults

19,90 (1975)

Cancer chemotherapy 8,431 (1965),20,465 (1976)

Cancerostatic drugs 20,521 (1976)

Carcinogens, molecular geometry and mechanism of action

4, 407 (1962) Central dopamine receptors, agents acting on

21,409 (1977) Central nervous system drugs, biochemical effects

8, 53 (1965) Chemotherapy of schistosomiasis, recent developments

16, II (1972) Cholera infection (experimental) and local immunity

19,471 (1975) Cholera in Hyderabad, epidemiology of

19,578 (1975) Cholera in Don-endemic regions

19, 594 (1975) Cholera, pandemic, and bacteriology

19,513 (1975) Cholera pathophysiology and therapeutics, advances

19, 563 (1975) Cholera, researches in India on the control and treatment of

19, 503 (1975) Cholera toxin induced fluid, effect of

Basic research, in the US pharmaceutical drugs on industry 19,519 (1975)

15,204 (1971) Cholera toxoid research in the United Benzodiazepine story States

22,229 (1978) 19,602 (1975) Bewertung eines neuen Antibiotikums Cholera vaccines in volunteers, antibody

22,327 (1978) response to Biochemical acyl hydroxylations 19, 554 (1975)

16,229 (1972) Cholera vibrios, interbiotype conversions Biological activity, stereochemical factors by actions of mutagens

1,455 (1959) 19,466 (1975) Biological response quantification in Cholesterol, relation to atherosclerosis toxicology, pharmacology and 1. 127 (1959) pharmacodynamics Cholinergic mechanism-monoamines

21, 105 (1977) relation in certain brain structures Bitoscanate, a field trial in India 6,334 (1972)

19,81 (1975)

Index Vol. 1-23

Clostridium tetani, growth in vivo 19, 384 (1975)

Communicable diseases, some often neglected factors in the control and prevention of

18,277 (1974) Contraception

21,293 (1977) Cyclopropane compounds

15,227 (1971)

Deworming of preschool community in national nutrition programmes

19, 136 (1975) Diarrhoea (acute) in children, management of

19, 527 (1975) Diarrhoeal diseases (acute) in children

19, 570 (1975) 3,4-Dihydroxyphenylalanine and related compounds

9, 223 (1966) Diphtheria, epidemiological observations in Bombay

19,423 (1975) Diphtheria, epidemiology of

19, 336 (1975) Diphtheria in Bombay

19,277 (1975) Diphtheria in Bombay, age profile of

19,417 (1975) Diphtheria in Bombay, studies on

19,241 (1975) Diphtheria, pertussis and tetanus, clinical study

19, 356 (1975) Diphtheria, pertussis and tetanus vaccines

19,229 (1975) Diphtheria toxin production and iron

19,283 (1975) Disease control in Asia and Africa, implementation of

18,43 (1974) Diuretics

2,9(1960) Drug action and assay by microbial kinetics

15,271 (1971) Drug action, basic mechanisms

7, 11 (1964) Drug combination, reduction of drug action

14, 11 (1970)

289

Drug in biological cells 20,261 (1976)

Drug latentiation 4,221 (1962)

Drug-macromolecular interactions, implications for pharmacological activity

14, 59 (1970) Drug metabolism

13, 136 (1969) Drug metabolism (microsomal), enhancement and inhibition of

17, 12 (1973) Drug potency

15, 123 (1971) Drug research

10, 11 (1966) Drug research and development

20, 159 (1976) Drugs, biliary excretion and enterohepatic circulation

9, 299 (1966)

Egg-white, reactivity of rat and man 13,340 (1969)

Endocrinology, twenty years of research 12, l37 (1968)

Endotoxin and the pathogenesis of fever 19,402 (1975)

Enterobacterial infections, chemotherapy of

12,370 (1968)

Filarial infection, immuno-diagnosis 19, 128 (1975)

Filariasis, chemotherapy 9, 191 (1966)

Filariasis in India 18, 173 (1974)

Filariasis, in four villages near Bombay, epidemiological and biochemical studies in

18,269 (1974) Filariasis, malaria and leprosy, new perspectives on the chemotherapy of

18,99 (1974) Fluor, derives organiques d'interet pharmacologique

3, 9 (1961) Fundamental structures in drug research Part I

20,385 (1976) Fundamental structures in drug research Part II

22,27 (1978)

290

Galenische Formgebung und Arzneimittelwirkung

10, 204 (1966), 14. 269 (1970) Ganglienblocker

2,297 (1960)

Heilmittel, Entwicklung 10,33 (1966)

Helminthiasis (intestinal), chemotherapy of

Index Vol. 1-23

Immunization of a village, a new approach to herd immunity

19,252 (1975) Immunization, progress in

19,274 (1975) Immunology

20, 573 (1976) Immunosuppression agents, procedures, speculations and prognosis

16,67 (1972) 19, 158 (1975) Impact of natural product research on

Helminth infections, progress in the drug discovery experimental chemotherapy of 23,51 (1979)

17,241 (1973) Indole compounds Helminthic infections, immuno- 6,75 (1963) diagnosis of Indolstruktur, in Medizin und Biologie

19, 119 (1975) 2,227 (1960) Homologous series, pharmacology Industrial drug research

7,305 (1964) 20, 143 (1976) Hookworm anaemia and intestinal Influenza virus, functional significance of malabsorption the various components of

19, 108 (1975) 18,253 (1974) Hookworm disease and trichuriasis, Interaction of drug research experience with bitoscanate 20, 181 (1976)

19,23 (1975) Intestinal nematodes, chemotherapy of Hookworm disease, bitoscanate in the 16, 157 (1972) treatment of children with Ionenaustauscher, Anwendung in

19,6(1975) Pharmazie und Medizin Hookworm disease, comparative study of 1, 11 (1959) drugs Isotope, Anwendung in der

19, 70 (1975) pharmazeutischen Forschung Hookworm disease, effect on the 7,59 (1964) structure and function of the small bowel

19,44(1975) Hookworm infection, a comparative study of drugs

19, 86 (1975) Human sleep

22,355 (1978) Hydatid disease

19, 75 (1975) Hydrocortisone, effects of structural alteration on the antiinflammatory properties

5,11(1963) 5-Hydroxytryptamine and related indolealkylamines

3, 151 (1961) Hypolipidemic agents

13,217 (1969)

Immunization, host factors in the response to

19,263 (1975)

Leishmaniases 18,289 (1974)

Leprosy, some neuropathologic and cellular aspects of

18,53 (1974) Leprosy in the Indian context, some practical problems of the epidemiology of

18,25 (1974) Leprosy, malaria and filariasis, new perspectives on the chemotherapy of

18,99 (1974) Levamisole

20, 347 (1976) Lipophilicity and drug activity

23,97 (1979) Lokalanasthetika, Konstitution und Wirksamkeit

4, 353 (1962) Lysostaphin: model for a specific enzymatic approach to infectious disease

16,309 (1972)

Index Vol. 1-23

Malaria chemotherapy, repository antimalarial drugs

13, 170 (1969) Malaria, eradication in India, problems of

18,245 (1974) Malaria, filariasis and leprosy, new perspectives on the chemotherapy of

18,99 (1974) Mass spectrometry in pharmaceutical research, recent applications of

18,399 (1974) Medical practice and medical pharmaceutical research

20,491 (1976) Medicinal chemistry, contribution to medicine

12, 11 (1968) Medicinal science

20,9(1976) Membrane drug receptors

20,323 (1976) Mescaline, and related compounds

11, 11 (1968) Metabolism of drugs, enzymatic mechanisms

6, 11 (1963) Metabolism (oxydative) of drugs and other foreign compounds

17,488 (1973) Metronidazol-Therapie, Trichomonasis

9,361 (1966) Molecular pharmacology

20, 101 (1976) Molecular pharmacology, basis for drug design

10,429 (1966) Monitoring adverse reactions to drugs

21,231 (1977) Monoaminoxydase-Hemmer

2,417 (1960)

Narcotic antagonists 8,261 (1965),20,45 (1976)

Necator american us infection, clinical field trial of bitoscanate

19,64 (1975) Nematoide infections (intestinal) in Latin America

19,28 (1975)

Parasitic infections in man, recent advances in the treatment of

18, 191 (1974)

Parasitosis (intestinal), analysis of symptoms and signs

19, 10 (1975) Pertussis agglutinins and complement fixing antibodies in whooping cough

19, 178 (1975)

291

Pertussis, diphtheria and tetanus, clinical study

19,356 (1975) Pertussis, diphtheria and tetanus vaccines

19,229 (1975) Pertussis, epidemiology of

19,257 (1975) Pertussis vaccine

19,341 (1975) Pertussis vaccine composition

19, 347 (1975) Pharmacology of the brain: the hippocampus, learning and seizures

16,211 (1972) Phenothiazine und Azaphenothiazine

5, 269 (1963) Photochemistry of drugs

11,48 (1968) Placeboproblem

1,279 (1959) Propellants, toxicity of

18,365 (1974) Prostaglandins

17,410 (1973) Protozoan and helminth parasites

20,433 (1976) Psychopharmaka, Anwendung in der psychosomatischen Medizin

10, 530 (1966) Psychopharmaka, strukturelle Betrach tungen

9, 129 (1966) Psychosomatische Medizin, Anwendung von Psychopharmaka

10, 530 (1966) Psychotomimetic agents

15,68 (1971)

Quaternary ammonium salts, chemical nature and pharmacological actions

2, 135 (1960) Quinazolones, biological activity

14,218 (1970) Quinuclidine derivatives, chemical structure and pharmacological activity

13, 293 (1969)

Red blood cell membrane, as a model for targets of drug action

17, 59 (1973)

292

Reproduction in women, pharmacological control

12,47 (1968) Research, preparing the ground: importance of data

18,239 (1974) Rheumatherapie, Synopsis

12, 165 (1968)

Schistosomiasis, recent progress in the chemotherapy of

18, 15 (1974) Schwefelverbindungen, therapeutisch verwendbare

4,9(1962) Shock, medical interpretation

14, 196 (1970) Social pharmacology

22,9(1978) Spectrofluorometry, physicochemical methods in pharmaceutical chemistry

6, 151 (1963) Stoffwechsel von Arzneimitteln, Ursache von Wirkung, Nebenwirkung und Toxizitiit

15, 147 (1971) Strahlenempfindlichkeit von Siiugetieren, Beeinflussung durch chemische Substanzen

9,11(1966) Structure-activity relationships

23, 199 (1979) Substruktur der Proteine, tabellarische Zusammenstellung

16,364 (1972) Sulfonamide research

12, 389 (1968)

Terpenoids, biological activity 6,279 (1963),13, 11 (1969)

Tetanus and its prevention 19, 391 (1975)

Tetanus, autonomic dysfunction as a problem in the treatment of

19,245 (1975) Tetanus, cephalic

19,443 (1975) Tetanus, cholinesterase restoring therapy

19, 329 (1975) Tetanus, diphtheria and pertussis, clinical study

19, 356 (1975) Tetanus, general and pathophysiological aspects

19,314 (1975)

Tetanus in children 19,209 (1975)

Index Vol. 1-23

Tetanus in Punjab and the role of muscle relaxants

19,288 (1975) Tetanus, mode of death

19,439 (1975) Tetanus neonatorum

19, 189 (1975) Tetanus, pertussis and diphtheria vaccines

19,229 (1975) Tetanus, present data on the pathogenesis of

19, 301 (1975) Tetanus, role of beta-adrenergic blocking drug propranolol

19, 361 (1975) Tetanus, situational clinical trials and therapeutics

19,367 (1975) Tetanus, therapeutic measurement

19,323 (1975) Tetracyclines

17,210(1973) Thymoleptika, Biochemie und Pharmakologie

11, 121 (1968) Toxoplasmosis

18,205 (1974) Trichomonasis, Metronidazol-Therapie

9, 361 (1966) Trichuriasis and hookworm disease in Mexico, experience with bitoscanate

19, 23 (1975) Tropical medicine, teaching

18,35 (1974) Tuberculosis in rural areas of Maharashtra, profile of

18,91 (1974) Tuberkulose, antibakterielle Chemotherapie

7, 193 (1964) Tumor promoters and antitumor agents

23,63 (1979)

Unsolved problems with vaccines 23,9(1979)

Vaccines, controlled field trials of 19,481 (1975)

Vibrio cholerae, cell-wall antigens of 19,612 (1975)

Index Vol. 1-23

Vibrio cholerae, recent studies on genetic recombination

19,460 (1975) Vibrio cholerae, virulence-enhancing effect of ferric ammonium citrate on

19,546 (1975) Vibrio parahaemolyticus in Bombay

19,586 (1975)

Vibrio parahaemolyticus infection in Calcutta

19,490 (1975)

Wurmkrankheiten, Chemotherapie 1, 159 (1959)

293

295

Author and Paper Index Autoren- und Artikelindex Index des auteurs et des articles

Vol. 1-23 (1959-1979)

Pertussis agglutinins and complement fixing antibodies in whooping cough 19,178(1975)

Pharmacology of clinically useful beta-adrenergic blocking drugs 15, 103 (1971)

Adrenergic beta blocking agents 20,27 (1976)

Trial of a new anthelmintic (bitoscanate) in ankylostomiasis in children 19,2(1975)

Development of antibacterial agents of the nalidixic acid type 21,9(1977)

Biological activity in the quinazolone series 14,218 (1970)

Dr. K. C. Agarwal Dr. M. Ray Dr. N.L. Chitkara Department of Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Prof. Dr. R.P. Ahlquist Professor of Pharmacology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA Dr. A. M. Karow, Jr. Assistant Professor of Pharmacology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA Dr. M.W. Riley Assistant Professor of Pharmacology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA

Prof. Dr. R. P. Ahlquist Professor of Pharmacology, Medical College of Georgia, Augusta, Georgia, USA

Dr. S. H. Ahmed Dr. S. Vaishnava Department of Paediatrics, Safdarjung Hospital, New Delhi, India

Dr. R. Albrecht Department of Drug Research, Schering AG, Berlin

Dr. A.H. Amin Director of Research, Alembic Chemical Works Co. Ltd., Alembic Road, Baroda 3, India Dr. D.R. Mehta Dr. S. S. Samarth Research Division, Alembic Chemical Works Co. Ltd., Alembic Road, Baroda 3, India

296

Enhancement and inhibition of microsomal drug metabolism 17, 11(1973)

Reactivity of rat and man to egg-white 13, 340 (1969)

Narcotic antagonists 8,261 (1965)

Recent developments in the chemotherapy of schistosomiasis 16, 11 (1972)

Recent progress in the chemotherapy of schistosomiasis 18, 15 (1974)

Recent progress in research on narcotic antagonists 20,45 (1976)

Molecular geometry and mechanism of action of chemical carcinogens 4, 407 (1962)

Molecular pharmacology, a basis for drug design 10, 429 (1966) Reduction of drug action by drug combination 14, 11 (1970)

Index Vol. 1-23

Prof. Dr. M. W. Anders Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA

Dr. S. I. Ankier Allen & Hanburys Ltd., Research Division, Ware, Hertfordshire, England

Dr. S. Archer Assistant Director of Chemical Research, Sterling-Winthrop Research Institute, Rensselaer, New York, USA Dr. L. S. Harris Section Head in Pharmacology, Sterling­Winthrop Research Institute, Rensselaer, New York, USA

Dr. S. Archer Associate Director of Research, Sterling­Winthrop Research Institute, Rensselaer, New York, USA Dr. A. Yarinsky Sterling-Winthrop Research Institute, Rensselaer, New York, USA

Prof. Dr. S. Archer Professor of Medicinal Chemistry, School of Science, Department of Chemistry, Rensselaer Polytechnic Institute. Troy, N. Y. 12181, USA

Prof. Dr. S. Archer Professor of Medicinal Chemistry, School of Science, Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York, USA Dr. W. F. Michne Sterling-Winthrop Research Institute, Rensselaer, New York, USA

Prof. Dr. J.e. Arcos Department of Medicine and Biochemistry, Tulane University, U. S. Public Health Service, New Orleans, Louisiana, USA

Prof. Dr. E. J. Ariens Institute of Pharmacology, University of Nijmegen, Nijmegen, The Netherlands

Index Vol. 1-23

Stereoselectivity and affinity in molecular pharmacology 20, 101 (1976)

Tetanus neonatorum 19, 189 (1975) Tetanus in children 19,209 (1975)

Toxicity of propellants 18,365 (1974)

Neuere Aspekte der chemischen Anthelminticaforschung 1, 243 (1959)

Problems in preparation, testing and use of diphtheria, pertussis and tetanus vaccines 19, 229 (1975)

Recent advances in electrophysiology of antiarrhythmic drugs 17,33 (1973)

Stereochemical factors in biological activity 1,455 (1959)

Industrial research in the quest for new medicines 20, 143 (1976)

Newer diuretics 2, 9 (1960)

Prof. Dr. E.J. Ariens Dr. J.F. Rodrigues de Miranda Pharmacological Institute, University of Nijmegen, Nijmegen, The Netherlands Prof. Dr. P.A. Lehmann F. Departamento de Farmacologia y Toxicologia, Centro de Investigacion y Estudios Avanzados, Instituto Politecnico Nacional, Mexico D.F., Mexico

Dr. V.B. Athavale Dr. P.N. Pai Dr. A. F emandez Dr. P.N. Patnekar Dr. Y. S. Acharya Department of Pediatrics, L. T. M. G. Hospital, Sion, Bombay 22, India

Prof. Dr. D.M. Aviado

297

Professor of Pharmacology, Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, USA

Dr. J. Bally Wissenschaftlicher Mitarbeiter der SandozAG, Basel, Schweiz

Dr. D.D. Banker Chief Bacteriologist, Glaxo Laboratories (India) Ltd., Bombay 25, India

Prof. Dr. A. L. Bassett and Dr. A. L. Wit College of Physicians and Surgeons of Columbia University, Department of Pharmacology, New York, N. Y., USA

Prof. Dr. A. H. Beckett Head of School of Pharmacy, Chelsea College of Science and Technology, Chelsea, London, England

Dr. B. Berde Head of Pharmaceutical Research and Development, Sandoz Ltd., Basle, Switzerland

Dr. K. H. Beyer, Jr. Vice-President, Merck Sharp and Dohme Research Laboratoires, West Point, Pennsylvania, USA Dr. J. E. Baer Director of Pharmacological Chemistry, Merck Institute for Therapeutic Research, West Point, Pennsylvania, USA

298

Studies on diphteria in Bombay 19,241 (1975)

Bitoscanate in children with hookworm disease 19,6(1975)

Recent studies on genetic recombination in Vibrio cholerae 19,460 (1975)

Interbiotype conversion of cholera vibrios by action of mutagens 19, 466 (1975)

Experience with bitoscanate in hookworm disease and trichuriasis in Mexico 19,23 (1975)

Analysis of symptoms and signs related with intestinal parasi tosis in 5,215 cases 19, 10 (1975)

Untersuchungen zur Biochemie und Pharmakologie der Thymoleptika 11, 121 (1968)

The p-adrenergic blocking agents, pharmacology, and structure-activity relationships 10,46 (1966)

Prostaglandins 17,410 (1973)

The red blood cell membrane as a model for targets of drug action 17,59 (1973)

Epidemiology and public health. Importance of intestinal nematode infections in Latin America 19, 28 (1975)

M. Bhaindarkar Y.S. Nimbkar

Index Vol. 1-23

Haffkine Institute, Parel, Bombay 12, India

Dr. B. Bhandari Dr. L. N. Shrimali Department of Child Health, R. N. T. Medical College, Udaipur, India

Dr. K. Bhaskaran Central Drug Research Institute, Lucknow, India

Dr. P. Bhattacharya Dr. S. Ray WHO International Vibrio Reference Centre, Cholera Research Centre, Calcutta 25, India

Prof. Dr. F. Biagi Departamento de Parasitologia, Facultad de Medicina, Universidad Nacional Aut6noma de Mexico, Mexico

Prof. Dr. F. Biagi Dr. R. L6pez Dr. J. Viso Departamento de Parasitologia, Facultad de Medicina, Universidad Nacional Aut6noma de Mexico, Mexico

Dr. M. H. Bickel Privatdozent, Medizinisch-Chemisches Institut der Universitat Bern, Schweiz

Dr. J. H. Biel Vice-President, Research and Development, Aldrich Chemical Company Inc., Milwaukee, Wisconsin, USA Dr. B. K. B. Lum Department of Pharmacology, Marquette University School of Medicine, Milwaukee, Wisconsin, USA

Dr. J. S. Bindra and Dr. R. Bindra Medical Research Laboratories, Pfizer Inc., Groton, Connecticut, USA

Prof. Dr. L. Bolis Universita degli Studi di Roma, Istituto di Fisiologia Generale, Roma, Italia

Prof. Dr. D. Botero R. School of Medicine, University of Antioquia, Medellin, Colombia

Index Vol. 1-23

Some practical problems of the epidemiology ofleprosy in the indian context 18,25 (1974)

Die Ionenaustauscher und ihre Anwendung in der Pharmazie und Medizin 1, 11 (1959) Wert und Bewertung der Arzneimittel 10,90 (1966)

Cyclopropane compounds of biological interest 15,227 (1971) The state of medicinal science 20,9(1976)

Human and veterinary anthelmintics (1965-1971) 17, 108 (1973)

The antibody basis of local immunity to experimental cholera infection in the rabbit ileal loop 19,471 (1975)

Les derives organiques du fluor d'interet pharmacologique 3,9(1961)

Teaching tropical medicine 18,35 (1974)

Anabolic steroids 2, 71 (1960)

Imm unosuppression­agents, procedures, speculations and prognosis 16,67 (1972)

299

Dr. S. G. Browne Director, Leprosy Study Centre, 57a Wimpole Street, London, England

Prof. Dr. J. Buchi Direktor des Pharmazeutischen Institutes der ETH, Zurich, Schweiz

Prof. Dr. A. Burger Professor Emeritus, University of Virginia, Charlottesville, Virginia, USA

Dr. R. B. Burrows Mount Holly, New Jersey, USA

Dr. W. Burrows Dr.J. Kaur University of Chicago, P.O.B. 455, Cobden, Illinois, USA

Prof. Dr. N.P. Buu-Hoi Directeur de Laboratoire it l'Institut de chimie des substances naturelles du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

Prof. Dr. K. M. Cahill Tropical Disease Center, 100 East 77th Street, New York City 10021, N. Y., USA

Prof. Dr. B. Camerino Director of the Chemical Research Laboratory of Farmitalia, Milan, Italy Prof. Dr. G. Sala Department of Clinical Chemistry and Medical Pathology, University of Milan, and Director of the Department of Pharmaceutical Therapy, Farmitalia, Milan, Italy

Dr. G. W. Camiener Research Laboratories, The Upjohn Company, Kalamazoo, Michigan, USA Dr. W.J. Wechter Research Head, Hypersensitivity Diseases Research, The Upjohn Company, Kalamazoo, Michigan, USA

300

Analgesics and their antagonists: recent developments 22, 149 (1978)

Chemical nature and pharmacological actions of quaternary ammonium salts 2, 135 (1960)

Contributions of medicinal chemistry to medicine - from 1935 12, 11 (1968)

Changing influences on goals and incentives in drug research and development 20, 159 (1976)

Uber Vorkommen und Bedeutung der Indolstruktur in der Medizin und Biologie 2, 227 (1960)

Cholesterol and its relation to atherosclerosis 1, 127 (1959)

Effect of hookworm disease on the structure and function of small bowel· 19, 44 (1975)

The psychotomimetic agents 15,68 (1971)

Implementation of disease control in Asia and Africa 18,43 (1974)

Index Vol. 1-23

Dr. A. F. Casy Norfolk and Norwich Hospital and University of East Anglia, Norwich, Norfolk, England

Prof. Dr. C.l. Cavallito Professor, Medicinal Chemistry, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA Dr. A.P. Gray Director of the Chemical Research Section, Neisler Laboratories Inc., Decatur, Illinois, USA

Prof. Dr. C.l. Cavallito Professor, Medicinal Chemistry, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA

Prof. Dr. C.l. Cavallito Ayerst Laboratories, Inc., New York, N. Y., USA

Dr. A. Cerletti Direktor der medizinisch-biologischen Forschungsabteilung der Sandoz AG, Basel, Schweiz

Prof. Dr. K. K. Chen Department of Pharmacology, University School of Medicine, Indianapolis, Indiana, USA Dr. Tsung-Min Lin Senior Pharmacologist, Division of Pharmacologic Research, Lilly Research Laboratories, Indianapolis, Indiana, USA

Prof. Dr. H. K. Chuttani Prof. Dr. R. C. Misra Maulana Azad Medical College & Associated Irwin and G. B. Pant Hospitals, New Delhi, India

Dr. S. Cohen Director, Division of Narcotic Addiction and Drug Abuse, National Institute of Mental Health, Chevy Chase, Maryland, USA

Prof. Dr. M. l. Colbourne Department of Preventive & Social Medicine, University of Hong Kong, Sassoon Road, Hong Kong

Index Vol. 1-23

Structure-activity relationships in certain anthelminties 3, 75 (1961)

Contribution of Hafikine to the concept and practice of controlled field trials of vaccines 19,481 (1975)

Antifungal agents 22,93 (1978)

Some neuropathologic and cellular aspects of leprosy 18,53 (1974)

Autonomic dysfunction as a problem in the treatment of tetanus 19,245 (1975)

Studies on V. parahaemolyticus infection in Calcutta as compared to cholera infection 19,490 (1975)

Biochemical effects of drugs acting on the central nervous system 8,53 (1965)

Drug research - whence and whither 10, II (1966)

Prof. Dr. J. C. Craig Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA Dr. M.E. Tate Post Doctoral Fellow, University of New South Wales, Department of Organic Chemistry, Kensington, N.S.W., Australia

Dr. B. Cvjetanovic

301

Chief Medical Officer, Bacterial Diseases, Division of Communicable Diseases, WHO, Geneva, Switzerland

Prof. Dr. P.F. D'Arcy Dr. E.M. Scott Department of Pharmacy, The Queen's University of Belfast, Northern Ireland

Prof. Dr. D.K. Dastur Dr. Y. Ramamohan Dr. A. S. Dabholkar Neuropathology Unit, Grant Medical College and J.J. Group of Hospitals, Bombay 8, India

Prof. Dr. F.D. Dastur Dr. G.J. Bhat Dr. K.G. Nair Department of Medicine, Seth G. S. Medical College and K.E.M. Hospital, Bombay 12, India

Dr. B.C. Deb Senior Research Officer, Cholera Research Centre, Calcutta, India

Dr. L. Decsi Specialist in Clinical Chemistry, University Medical School, Pees, Hungary

Dr. R.G. Denkewalter Vice-President for Exploratory Research, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA Dr. M. Tishler President, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA

302

Hypolipidemic agents 13,217 (1969)

The interface between drug research, marketing, management, and social, political and regulatory forces 20, 181 (1976)

Antihypertensive Agents 20, 197 (1976)

Transport and accumulation in biological cell systems interacting with drugs 20,261 (1976)

Immunization of a village, a new approach to herd immunity 19,252 (1975)

Surgical amoebiasis 18,77(1974)

Epidemiology of pertussis 19, 257 (1975)

Profiles of tuberculosis in rural areas of Maharashtra 18,91 (1974)

Aminonuc1eosid-nephrose 7,341 (1964)

Index Vol. 1-23

Dr. G. De Stevens Vice-President and Director of Research, CIBA Pharmaceutical Company, Summit, New Jersey, USA Dr. W.L. Bencze Research Department, CIBA Pharmaceutical Company, Summit, New Jersey, USA Dr. R. Hess CIBA Limited, Basle, Switzerland

Dr. G. De Stevens Executive Vice President & Director of Research, Pharmaceuticals Division, CIBA­GEIGY Corporation, Summit, New Jersey, USA

Dr. G. De Stevens Dr. M. Wilhelm Pharmaceuticals Division, CIBA-GEIGY Corporation, Summit, New Jersey, USA

Dr. W. Dorst Dr. A. F. Bottse Department of Pharmacology, Vrije Universiteit, Amsterdam, The Netherlands Dr. G.M. Willems Biomedical Centre, Medical Faculty, Maastricht, The Netherlands

Prof. Dr. N.S. Deodhar Head of Department of Preventive and Social Medicine, B.J. Medical College, Poona, India

Dr. A. E. deSa Bombay Hospital, Bombay, India

Dr. J.A. D'Sa Glaxo Laboratories (India) Limited, Worli, Bombay 25, India

Prof. Dr. M. D. Deshmukh Honorary Director Dr. K.G. Kulkarni Deputy Director Dr. S. S. Virdi Senior Research Officer Dr. B.B. Yodh Memorial Tuberculosis Reference Laboratory and Research Centre, Bombay, India

Dr. U. C. Dubach Privatdozent, Oberarzt an der Medizinischen UniversitiHs-Poliklinik Basel, Schweiz

Index Vol. 1-23

1m pact of researches in India on the control and treatment of cholera 19, 503 (1975)

Laboratory methods in the screening of anthelmintics 19,48 (1975)

Progress in immunization 19,274 (1975)

Host factors in the response to immunization 19,263 (1975)

Drug-macromolecular interactions: implications for pharmacological activity 14, 59 (1970)

Betrachtungen zur Entwicklung von Heilmitteln 10,33 (1966)

Progress in malaria chemotherapy. Part 1. Repository antimalarial drugs 13, 170 (1969) New perspectives on the chemotherapy of malaria, filariasis and leprosy 18,99 (1974)

Recent research in the field of 5-hydroxytryptamine and related indolealkylamines 3,151 (1961)

Dr. N.K. Dutta Director, Vaccine Institute, Baroda, India

Dr. D. Duwel Helminthology Department,

303

Farbwerke Hoechst AG, Frankfurt/Main 80, Federal Republic of Germany

Prof. Dr. G. Edsall Department of Microbiology, London School of Hygiene and Tropical Medicine, London W.C.I, England

Prof. Dr. G. Edsall Department of Microbiology, London School of Hygiene and Tropical Medicine, London, W.C.I, England M.A. Belsey World Health Organization, Geneva, Switzerland D.R. LeBlanc Tulane University School of Public Health and Tropical Medicine, New Orleans, La., USA L. Levine State Laboratory Institute, Boston, Mass., USA

Dr. S. Ehrenpreis Associate Professor and Head Department of Pharmacology, New York Medical College, Fifth Avenue at 106th Street, New York, N.Y. 10029, USA

Prof. Dr. G. Ehrhart Farbwerke Hoechst AG, Frankfurt a.M.-Hochst, BR Deutschland

Dr. E.F. Elslager Section Director, Chemistry Department, Parke, Davis & Company, Ann Arbor, Michigan, USA

Prof. Dr. V. Erspamer Institute of Pharmacology, University of Parma, Parma, Italy

304

Bacteriology at the periphery of the cholera pandemic 19,513 (1975)

Iron and diphtheria toxin production 19,283 (1975)

Effect of drugs on cholera toxin induced fluid in adult rabbit ileal loop 19,519 (1975)

Drug action and assay by microbial kinetics 15,519 (1971)

The pharmacokinetic bases of biological response quantification in toxicology, pharmacology and pharmacodynamics 21, 105 (1977)

The chemotherapy of enterobacterial infections 12,370 (1968)

Metabolism of drugs and other foreign compounds by enzymatic mechanisms 6, 11 (1963)

The art and science of contemporary drug development 16, 194 (1972)

Basic mechanisms of drug action 7, 11 (1964) Isolation and characterization of membrane drug receptors 20, 323 (1976)

Zusammenhange zwischen Konstitution und Wirksamkeit bei Lokalanasthetica 4,353 (1962)

Index Vol. 1-23

Dr. A. L. Furniss Public Health Laboratory, Maidstone, England

Dr. S. V. Gadre Dr. S.S. Rao Hafikine Institute, Bombay 12, India

Dr. B. B. Gaitonde Dr. P. H. Marker Dr.N.R.Rao Haffkine Institute, Bombay 12, India

Prof. Dr. E. R. Garrett Graduate Research Professor The J. Hillis Miller Health Center, College of Pharmacy, University of Florida, Gainesville, Florida, USA

Prof. Dr. L.P. Garrod Department of Bacteriology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England

Dr. J.R. Gillette Head, Section on Enzymes Drug Interaction, Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda 14, Maryland, USA

Dr. A. J. Gordon Associate Director, Department of Scientific Affairs, Pfizer Pharmaceuticals, 235 East 42nd Street, New York, USA Dr. S. G. Gilgore President, Pfizer Pharmaceuticals, 235 East 42nd Street, New York, USA

Prof. Dr. D.R.H. Gourley Department of Pharmacology, Eastern Virginia Medical School, Norfolk, Virginia, USA

Dr. H. Grasshof Forschungschemiker in Firma M. Woelm, Eschwege, Deutschland

Index Vol. 1-23

Das Placeboproblem 1,279 (1959)

Clinical field trial of bitoscanate in Necator americanus infection, South Thailand 19, 64 (1975)

Pharmacological control of reproduction in women 12,47 (1968) Contraception - retrospect and prospect 21,293 (1977)

Drug latentiation 4,221 (1962)

Chemotherapy of filariasis 9, 191 (1966) Filariasis in India 18, 173 (1974)

Recent studies in the field of indole compounds 6, 75 (1963)

Neuere Entwicklungen auf dem Gebiete therapeutisch verwendbarer organischer Schwefelverbindungen 4, 9 (1962)

The management of acute diarrhea in children: an overview 19, 527 (1975)

The tetracyclines 17, 2lO (1973)

Relationship of induced antibody titres to resistance to experimental human infection 19, 542 (1975)

305

Prof. Dr. H. Haas Leiter der Pharmakologischen Abteilung Knoll AG, Ludwigshafen, und Dozent an der Universitat Heidelberg Dr. H. Fink und Dr. G. Hartefelder Forschungslaboratorien der Knoll AG, Ludwigshafen, Deutschland

Dr. T. Harinasuta Dr. D. Bunnag Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Prof. Dr. M.J.K. Harper The University of Texas, Health Science Center at San Antonio, San Antonio, Texas, USA

Prof. Dr. N.J. Harper Head of the Department of Pharmacy, University of Aston, Birmingham 4, England

Dr. F. Hawking Clinical Research Centre, Watford Road, Harrow, Middlesex, England

Dr. R. V. Heinzelman Section Head, Organic Chemistry, The Upjohn Company, Kalamazoo, Michigan, USA Dr. J. Szmuszkovicz Research Chemist, The Upjohn Company, Kalamazoo, Michigan, USA

Dr. H. Herbst Forschungschemiker in den Farbwerken Hoechst, Frankfurt a.M., Deutschland

Dr. N. Hirschhorn Consultant Physician and Staff Associate, Management Sciences for Health, One Broadway, Cambridge, Mass., USA

Dr. J.J. Hlavka and Dr. J.H. Booth Lederle Laboratories, Pearl River, N.Y., USA

Dr. R. B. Hornick Dr. R. A. Cash Dr. J. P. Libonati The University of Maryland School of Medicine, Division of Infectious Diseases, Baltimore, Maryland, USA

306

Recent applications of mass spectrometry in pharmaceutical research 18, 399 (1974)

The pharmacology of homologous series 7,305 (1964)

Progress in the experimental chemotherapy of helminth infections. Part 1. Trematode and cestode diseases 17,241 (1973)

Pharmacology of the brain: the hippocampus, learning and seizures 16,211 (1972)

Cholinergic mechanism -monoamines relation in certain brain structures 16, 334 (1972)

The development of antifertility substances 7, 133 (1964)

Agents acting on central dopamine receptors 21,409 (1977)

Recent advances in the treatment of parasitic infections in man 18, 191 (1974) The levamisole story 20, 347 (1976)

A comparative study of bit os can ate, bephenium hydroxynaphthoate and tetrachlorethylene in hookworm infection 19, 70 (1975)

Index Vol. 1-23

Mag. Sc. Chem. G. Horvath Research Chemist, Research Institute for Pharmaceutical Chemistry, Budapest, Hungary

Dr. H.R. Ing Reader in Chemical Pharmacology, Oxford University, and Head of the Chemical Unit of the University Department of Pharmacology, Oxford, England

Dr. P.J. Islip The Wellcome Research Laboratories, Beckenham, Kent, England

Prof. Dr. I. Izquierdo Dr. A.G. Nasello Departamento de Farmacologia, Facultad de Ciencias Quimicas, Upiversidad N acional de C6rdoba, Estafeta 32, C6rdoba, Argentina

Prof. Dr. J.A. Izquierdo Department of Experimental Pharmacology, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina

Prof. Dr. H. Jackson Head of Department of Experimental Chemotherapy, Christie Hospital and Holt Radium Institute, Paterson Laboratories, Manchester 20, England

Dr. P. C. Jain Dr. N. Kumar Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India

Dr. P.A.J. Janssen Director, Janssen Pharmaceutica, Research Laboratories, Beerse, Belgium

Dr. S. Johnson Department of Medicine III, Christian Medical College Hospital, Vellore, Tamilnadu, India

Index Vol. 1-23

Tetanus in Punjab with particular reference to the role of muscle relaxants in its management 19,288 (1975)

Virulence-enhancing effect of ferric ammonium citrate on Vibrio cholerae 19,546 (1975)

Toxoplasmosis 18,205 (1974)

Tabellarische Zusammenstellung uber die Substruktur der Proteine 16,364 (1972)

Experimental evaluation of anti­tuberculous compounds, with special reference to the effect of combined treatment 18,211 (1974)

The oxidative metabolism of drugs and other foreign compounds 17,488 (1973)

Die Amidinstruktur in der Arzneistofforschung 11, 356 (1968)

Present data on the pathogenesis of tetanus 19,301 (1975) Tetanus: general and pathophysiological aspects; achievements, failures, perspectives of elaboration of the problem 19,314 (1975)

Lipophilicity and drug activity 23, 97 (1979)

Prof. Dr. S. S. Jolly Dr. J. Singh Dr. S. M. Singh

307

Department of Medicine, Medical College, Patiala, India

Dr. I. J06 Institute for Serobacteriological Production and Research 'HUMAN', WHO International Reference Centre for Bacterial Vaccines, Budapest, Hungary

Prof. Dr. B. H. Kean The New York Hospital- Cornell Medical Center, 525 East 68th Street, New York, N.Y., USA

Dr. R. Kleine Physiologisch-Chemisches Institut der Martin­Luther-Universitiit, 402 Halle (Saale), DDR

Dr. F. Kradolfer Head of Infectious Diseases Research, Biological Research Laboratories, Pharmaceutical Division, Ciba-Geigy Ltd., Basle, Switzerland

Dr. F. Kratz Medizinische Kliniken und Polikliniken, Justus-Liebig-Universitiit, Giessen, BR Deutschland

Prof. Dr. A. Kreutzberger Wissenschaftlicher Abteilungsvorsteher am Institut fUr pharmazeutische Chemie der Westfalischen Wilhelms-Universitiit Munster, Miinster (Westfalen), Deutschland

Prof. Dr. G. N. Kryzhanovsky Institute of General Pathology and Pathological Physiology, AMS USSR, Moscow, USSR

Dr. H. Kubinyi Chemical Research and Development of BASF Pharma Division, Knoll AG, Ludwigshafen/Rhein, Federal Republic of Germany

308

Klinisch-pharmakologische Kriterien in der Bewertung eines neuen Antibiotikums. Grundlagen und methodische Gesichtspunkte 22,327 (1978)

Index Vol. 1-23

Prof. Dr. H.P. Kuemmerle Miinchen/Eppstein, BR Deutschland

Uber neue Arzneimittel1, 531 (1959), Dr. W. Kunz 2,251 (1960),3,369 (1961), Forschungschemiker in Firma Dr. Schwarz 6,347 (1963), 10, 360 (1966) GmbH, Monheim (Rheinland), Deutschland

Die Anwendung von Psychopharmaka Dr. F. Labhardt in der psychosomatischen Medizin Privatdozent, stellvertretender Direktor der 10,530 (1966) psychiatrischen Universitatsklinik, Basel,

Schweiz

Therapeutic measurement in tetanus 19,323 (1975)

Physico chemical methods in pharmaceutical chemistry, 1. Spectrofiuorometry 6, 151 (1963)

Biochemical acyl hydroxylations 16,229 (1972)

Cholinesterase restoring therapy in tetanus 19, 329 (1975)

Interactions between androgenic­anabolic steroids and glucocorticoids 14, 139 (1970)

Prof. Dr. D.R. Laurence Department of Pharmacology, University College, London, and Medical Unit, University College Hospital Medical School, London, England

Dr. H.G. Leemann Head of the Analytical Department in the Pharmaceutical Division of Sandoz Ltd, Basle, Switzerland Dr. K. Stich Specialist for Questions in Ultraviolet and Fluorescence Spectrophotometry, Analytical Department, Sandoz Ltd., Bas1e, Switzerland Dr. Margrit Thomas Research Chemist in the Analytical Department Research Laboratory, Sandoz Ltd., Basle, Switzerland

Dr. W. Lenk Pharmakologisches Institut der Universitat Miinchen, Nussbaumstrasse 26, Miinchen, Deutschalnd

Prof. Dr. G. Leonardi Department of Medicine, St. Thomas Hospital, Portogruaro, Venice, Italy Dr. K.G. Nair Prof. Dr. F.D. Dastur Department of Medicine, Seth G. S. Medical College and K. E. M. Hospital, Bombay 12, India

Dr. O. Linet Sinai Hospital of Detroit, Department of Medicine, 6767 West Outer Drive, Detroit, Michigan 48235

Index Vol. 1-23

Reactivity of bentonite flocculation, indirect haem agglutination and casoni tests in hydatid disease 19, 75 (1975)

Epidemiology of diphtheria 19,336 (1975)

Biological activity of the terpenoids and their derivatives 6,279 (1963)

Biological activity of the terpenoids and their derivatives - recent advances 13, 11 (1969)

An tih ypertensive agents 1962-1968 13, 101 (1969) Fundamental structures in drug research - Part I 20, 385 (1976) Fundamental structures in drug research - Part II 22,27 (1978)

Relationships between the chemical structure and pharmacological activity in a series of synthetic quinuclidine derivatives 13,293 (1969)

On the understanding of drug potency 15, 123 (1971) The chemotherapy of intestinal nematodes 16, 157 (1972)

Dr. R. C. Mahajan Dr. N. L. Chitkara Division of Parasitology, Department of Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Dr. L.G. Marquis

309

Glaxo Laboratories (India) Limited, Worli, Bombay 25, India

Dr. M. Martin-Smith Reader in Pharmaceutical Chemistry, University of Strathclyde, Department of Pharmaceutical Chemistry, Glasgow, C. 1, Scotland Dr. T. Khatoon Lecturer in Chemistry at the Eden Girls College, Dacca, East Pakistan

Dr. M. Martin-Smith Reader in Pharmaceutical Chemistry, University of Strathclyde, Glasgow, C. 1, Scotland Dr. W. E. Sneader Lecturer in Pharmaceutical Chemistry, University of Strathclyde, Glasgow, C. 1, Scotland

Prof. Dr. A. Marxer Dr. O. Schier Chemical Research Department, Pharmaceuticals Division, Ciba-Geigy Ltd., Basle, Switzerland

Prof. Dr. M. D. Mashkovsky All-Union Chemical Pharmaceutical Research Institute, Moscow, USSR Dr. L.N. Yakhontov All-Union Chemical Pharmaceutical Research Institute, Moscow, USSR

Dr. J. W. McFarland Pfizer Medical Research Laboratories, Groton, Connecticut, USA

310

Zur Beeinfiussung der Strahlen­empfindlichkeit von Saugetieren durch chemische Substanzen 9, 11 (1966)

Analgesian and addiction 5, 155 (1963)

Comparative drug metabolism 13, 136 (1969)

Pathogenesis of amebic disease 18,225 (1974) Protozoan and helminth parasites -a review of current treatment 20,433 (1976)

Synopsis der Rheumatherapie 12, 165 (1968)

On the chemotherapy of cancer 8, 431 (1965) The relationship of the metabolism of anticancer agents to their activity 17,320 (1973) The current status of cancer chemotherapy 20,465 (1976)

Der Einfiuss der Formgebung auf die Wirkung eines Arzneimittels 10,204 (1966) Galenische Formgebung und Arzneimittelwirkung. Neue Erkenntnisse und Feststellungen 14, 269 (1970)

Index Vol. 1-23

Dr. H.-J. Melching Privatdozent, Oberassistent am Radiologischen Institut der Universitat Freiburg i.Br., Freiburg i.Br., Deutschland Dr. C. Streffer Wissenschaftlicher Mitarbeiter am Radiologischen Institut der Universitat Freiburg i.Br., Freiburg i.Br., Deutschland

Dr. L. B. Mellett Assistant Professor of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA Prof. Dr. L.A. Woods Department of Pharmacology, College of Medicine, State University ofIowa, Iowa City, USA

Dr. L. B. Mellett Head, Pharmacology & Toxicology, Kettering-Meyer Laboratories, Southern Research Institute, Birmingham, Alabama, USA

Prof. Dr. M.J. Miller Tulane University, Department of Tropical Medicine, New Orleans, Louisiana, USA

Dr. W. Moll Spezialarzt FMH Innere Medizin -Rheumatologie, Basel, Schweiz

Dr. J.A. Montgomery Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama, USA

Prof. Dr. K. Miinzel Leiter der galenischen Forschungsabteilung der F. Hoffmann-La Roche & Co. AG, Basel, Schweiz

Index Vol. 1-23

A field trial with bitoscanate in India 19,81 (1975)

Comparative study of bitoscanate, bephenium hydroxynaphthoate and tetrachlorethylene in hookworm disease 19, 86 (1975)

Ganglienblocker 2, 297 (1960)

Recent advances in cholera pathophysiology and therapeutics 19,563 (1975)

Preparing the ground for research: importance of data 18, 239 (1974)

Antibody response to two cholera vaccines in volunteers 19, 554 (1975)

Die Chemotherapie der Wurmkrankheiten I, 159 (1959)

Drug research and human sleep 22,355 (1978)

An extensive community outbreak of acute diarrhoeal diseases in children 19, 570 (1975)

Dr. G.S. Mutalik Dr. R.B. Gulati Dr. A. K. Iqbal Department of Medicine, B.J. Medical College and Sassoon General Hospital, Poona, India

Dr. G.S. Mutalik Dr. R.B. Gulati Department of Medicine, B.J. Medical College and Sassoon General Hospital, Poona, India

Dr.K.Nador

311

o. Professor und Institutsdirektor, Chemisches Institut der Tierarztlichen Universitat, Budapest, Ungam

Prof. Dr. D.R. Nalin Johns Hopkins School of Medicine and School of Public Health. Guest Scientist, Cholera Research Hospital, Dacca, Bangladesh

Dr. A.N.D. Nanavati Assistant Director and Head, Department of Virology, Hatlkine Institute, Bombay, India

Y. S. Nimbkar R. S. Karbhari S. Cherian N. G. Chanderkar R. P. Bhamaria P.S. Ranadive Dr. B. B. Gaitonde Haffkine Institute, Parel, Bombay 12, India

Prof. Dr. H.-A. Oelkers Leiter der pharmakologischen und parasitologischen Abteilung der Firma C.F. Asche & Co., Hamburg-Altona, Deutschland

Prof. Dr. I. Oswald University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, Scotland

Dr. S.C. Pal Dr. C. Koteswar Rao Cholera Research Centre, Calcutta, India

312

3,4-Dihydroxyphenylalanine and related compounds 9, 223 (1966)

Mescaline and related compounds 11, 11 (1968)

Experience with bitoscanate in adults 19,90 (1975)

Monoaminoxydase-Hemmer 2,417 (1960)

What makes a good pertussis vaccine? 19,341 (1975) Vaccine composition in relation to antigenic variation of the microbe: is pertussis unique? 19, 347 (1975) Some unsolved problems with vaccines 23,9(1979)

Clinical study of diphtheria, pertussis and tetanus 19, 356 (1975)

Epidemiology of cholera in Hyderabad 19,578 (1975)

Index Vol. 1-23

Dr. A. R. Patel Post-Doctoral Research Assistant. Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA Prof. Dr. A. Burger Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA

Dr. A. R. Patel Post-Doctoral Research Assistant, Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA

Dr. A. H. Patricia Dr. U. Prabakar Rao Dr. R. Subramaniam Dr. N. Madanagopalan Madras Medical College, Madras, India

Prof. Dr. A. Pletscher Direktor der medizinischen Forschungsabteilung F. Hoffmann-La Roche & Co. AG, Basel, und Professor fUr Innere Medizin an der Universitat Basel Dr. K.F. Gey Medizinische Forschungsabteilung F. Hoffmann-La Roche & Co. AG, Basel Schweiz Dr. P. Zeller Chefchemiker in Firma F. Hoffmann-La Roche & Co. AG, Basel, Schweiz

Dr. N.W. Preston Department of Bacteriology and Virology, University of Manchester, Manchester, England

Dr. V.B. Raju Dr. V.R. Parvathi Institute of Child Health and Hospital for Children, Egmore, Madras 8, India

Dr. K. Rajyalakshmi Dr. P.V. Ramana Rao Institute of Preventive Medicine, Hyderabad, Andhra Pradesh, India

Index Vol. 1-23

Problems of malaria eradication in India 18, 245 (1974)

The photochemistry of drugs and related substances 11,48 (1968)

Orale Antikoagulantien 11,226 (1968)

Functional significance of the various components of the influenza virus 18, 253 (1974)

Role of beta-adrenergic blocking drug propranolol in severe tetanus 19,361 (1975)

Studies on Vibrio parahaemolyticus in Bombay 19, 586 (1975)

Clinical experience with bitoscanate 19,96 (1975)

Tetanus: Situational clinical trials and therapeutics 19,367 (1975)

Epidemiological studies on cholera in non-endemic regions with special reference to the problem of carrier state during epidemic and non-epidemic period 19, 594 (1975)

Dr. V.N. Rao Joint Director of Health Services (Health), Maharashtra, Bombay, India

Dr. S. T. Reid Lecturer in Chemical Pharmacology, Experimental Pharmacology Division, Institute of Physiology, The University, Glasgow, W.2, Scotland

Dr. E. Renk Dr. W.G. Stoll Wissenschaftliche Laboratorien der J. R. Geigy AG, Basel, Schweiz

Prof. Dr. R. Rott Institut fUr Virologie, Justus-Liebig­UniversitlH, Giessen, Deutschland

Prof. Dr. G.S. Sainani Head, Upgraded Department of Medicine, B.J. Medical College and Sassoon General Hospitals, Poona, India Dr. K. L. Jain Prof. Dr. V.R.D. Deshpande Dr. A. B. Balsara Dr. S.A. Iyer

313

Medical College and Hospital, Nagpur, India

Dr. F. L. Saldanha Dr. A. K. Patil Dr. M. V. Sant Haflkine Institute, Parel, Bombay 12, India

Dr. M.R. Samuel Head of the Department of Clinical Development, Medical Division, Hoechst Pharmaceuticals Limited, Bombay, India

Dr. R.K.M. Sanders Dr. M. L. Peacock Dr. B. Martyn Dr. B. D. Shende The Duncan Hospital, Raxaul, Bihar, India

Dr. M. V. Sant W.N. Gatlewar S. K. Bhindey Haflkine Institute, Parel, Bombay 12, India

314

Epidemiological and biochemical studies in filariasis in four villages near Bombay 18,269 (1974)

Hookworm anaemia and intestinal malabsorption associated with hookworm infestation 19, 108 (1975)

The effects of structural alteration on the anti-inflammatory properties of hydrocortisone 5,11 (1963)

The impact of natural product research on drug discovery 23,51 (1979)

Anti-filariasis campaign: its history and future prospects 18,259 (1974)

Immuno-diagnosis of helminthic infections 19, 119 (1975)

Immuno-diagnosis in filarial infection 19, 128 (1975)

Index Vol. 1-23

Dr. M. V. Sant, W.N. Gatlewar and T.U.K. Menon Department of Zoonosis and of Research Divison of Microbiology, Hafikine Institute, Bombay, India

Prof. Dr. A. K. Saraya Prof. Dr. B.N. Tandon Department of Pathology and Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India

Dr. L. H. Sarett Director of Synthetic Organic Chemistry, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA Dr. A. A. Patchett Director of the Department of Synthetic Organic Chemistry, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA Dr. S. Steelman Director of Endocrinology, Merck Institute for Therapeutic Research, Rahway, New Jersey, USA

Dr. L. H. Sarett Senior Vice-President for Science and Technology, Merck & Co., Inc., Rahway New Jersey, USA

Prof. Dr. M. Sasa Professor of Parasitology, Director of the Institute of Medical Science, University of Tokyo, Tokyo, Japan

Prof. Dr. T. Sawada Dr. K. Sato Dr. K. Takei Department of Parasitology, School of Medicine, Gunma University, Maebashi, Japan

Prof. Dr. T. Sawada Dr. K. Sato Dr. K. Takei Department of Parasitology, School of Medicine, Gunma University, Maebashi, Japan Dr. M. M. Goil Department of Zoology, Bareilly College, Bareilly (U.P.), India

Index Vol. 1-23

Quantitative structure­activity relationships 23, 199 (1979)

Phenothiazine und Azaphenothiazine als Arzneimittel 5,269 (1963)

Antihypertensive agents 4,295 (1962)

Die Anwendung radioaktiver Isotope in der pharmazeutischen Forschung 7, 59 (1964)

Natiirliche und synthetische Acetylen­Verbindungen als Arzneistoffe 14,387 (1970)

The structure and biogenesis of certain antibiotics 2,591 (1960)

Dr. A.K. Saxena Dr. S.Ram

315

Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India

Dr. E. Schenker Forschungschemiker in der Sandoz AG, Basel, Schweiz Dr. H. Herbst Forschungstechniker in den Farbwerken Hoechst, Frankfurt a.M., Deutschland

Dr. E. Schlittler Director of Research of CIBA Pharmaceutical Company, Summit, New Jersey, USA Dr.J. Druey Director of the Department of Synthetic Drug Research of CIBA Ltd., Basle, Switzerland Dr. A. Marxer Research Chemist of CIBA Ltd., Basle, and Lecturer at the University of Berne, Switzerland

Prof. Dr. K.E. Schulte Direktor des Instituts fUr Pharmazie und Lebensmittelchemie der Westfalischen Wilhelms-Universitlit Munster, Munster (Westfalen), Deutschland Dr. Ingeborg Mleinek Leiterin des Isotopen-Laboratoriums, Institut fUr Pharmazie und Lebensmittelchemie der Westfalischen Wilhelms-Universitlit Munster, Munster (Westfalen), Deutschland

Prof. Dr. K. E. Schulte Direktor des Instituts fUr pharmazeutische Chemie der Westfalischen Wilhelms­Universitlit Munster, Munster (Westfalen), Deutschland Dr. G. Rucker Dozent fUr pharmazeutische Chemie an der Westfalischen Wilhelms-Universitlit Munster, Munster (Westfalen), Deutschland

Dr. W.A. Sexton Research Director of the Pharmaceuticals Division of Imperial Chemical Industries Ltd., Wilmslow, Cheshire, England

316

Role of periodic deworming of preschool community in national nutrition programmes 19, 136 (1975)

Ayurvedic medicine - past and present 15, 11 (1971)

Mechanisms of anthelmintic action 19, 147 (1975)

Some often neglected factors in the control and prevention of communicable diseases 18,277 (1974)

Tetanus and its prevention 19,391 (1975)

Growth of Clostridium telani in vivo 19, 384 (1975)

The biliary excretion and enterohepatic circulation of drugs and other organic compounds 9, 299 (1966)

On the relation between chemical structure and function in certain tumor promoters and anti-tumor agents 23,63 (1979)

Gram-negative bacterial endotoxin and the pathogenesis of fever 19,402 (1975)

Index Vol. 1-23

Prof. Dr. P.M. Shah Institute of Child Health Dr. A. R. Junnarkar Reader in Preventive and Social Medicine Dr. R. D. Khare Research Assistant, Institute of Child Health, J.J. Group of Govemment Hospitals and Grant Medical College, Bombay, India

Dr. Shiv Sharma 'Baharestan', Bomanji Petit Road, Cumbalia Hill, Bombay, India

Prof. Dr. U.K. Sheth Seth G. S. Medical College and K. E. M. Hospital, Parel, Bombay 12, India

Dr. C.E.G. Smith Dean, London School of Hygiene and Tropical Medicine, Keppel Street, London, England

Dr. J. W.G. Smith Epidemiological Research Laboratory, Central Public Health Laboratory, London, England

Dr. J. W.G. Smith Epidemiological Research Laboratory, Central Public Health Laboratory, London, England Dr. A.G. Maciver Department of Morbid Anatomy, Faculty of Medicine, Southampton University, Southampton, England

Dr. R. L. Smith Senior Lecturer in Biochemistry at St. Mary's Hospital Medical School (University of London), Paddington, London, W.2, England

Prof. Dr. J. R. Smythies Department of Psychiatry, University of Alabama in Birmingham Medical Center, Birmingham, Alabama, USA

Dr. E. S. Snell Glaxo Laboratories Limited, Greenford, Middlesex, England

Index Vol. 1-23

Strukturelle Betrachtungen der Psychopharmaka: Versuch einer Korrelation von chemischer Konstitution und klinischer Wirkung 9, 129 (1966)

Chemotherapy of intestinal helminthiasis 19, 158 (1975)

The leishmaniases 18,289 (1974)

The benzodiazepine story 22,229 (1978)

Progress in sulfonamide research 12, 389 (1968) Problems of medical practice and of medical-pharmaceutical research 20,491 (1976)

Antiviral agents 22, 267 (1978)

Antiarrhythmic compounds 12,292 (1968)

Practically applicable results of twenty years of research in endocrinology 12, 137 (1968)

Age profile of diphtheria in Bombay 19,412 (1975)

Dr. K. Stach Stellvertretender Leiter der Chemischen Forschung der C. F. Boehringer & Sohne GmbH, Mannheim-Waldhof, Deutschland Dr. W. Poldinger

317

Oberarzt flir klinische Psychopharmakologie an der Psychiatrischen Universitatsklinik Basel, Basel, Schweiz

Dr. O.D. Standen The Wellcome Research Laboratories, Beckenham, Kent, England

Dr. E. A. Steck Department of the Army, Walter Reed Army Institute of Research, Division of Medicinal Chemistry, Washington, D.C., USA

Dr. L. H. Sternbach Research Department, Hoffmann-La Roche Inc., Nutley, New Jersey, USA

Dr. Th. Struller Research Department, F. Hoffmann-La Roche & Co. Ltd., Basle, Switzerland

Dr. D.L. Swallow Pharmaceuticals Division, Imperial Chemical Industries Limited, Alderley Park, Macclesfield, Cheshire, England

Prof. Dr. L. Szekeres Head of the Department of Pharmacology, School of Medicine, University ofSzeged, Szeged, Hungary Dr. J. G. Papp Senior Lecturer, University Department of Pharmacology, Oxford, England

Prof. Dr. M. Tausk State University of Utrecht, Faculty of Medicine, Utrecht, Netherlands

Prof. Dr. N.S. Tibrewala Dr. R. D. Potdar Dr. S. B. Talathi Dr. M.A. Ramnathkar Dr. A.D. Katdare Topiwala National Medical College, BYL Nair Hospital and Kasturba Hospital for Infectious Diseases, Bombay 11, India

318

Antibakterielle Chemotherapie der Tuberku10se 7, 193 (1964)

Diphtheria 19,423 (1975)

Bio10gische Oxydation und Reduktion am Stickstoff aromatischer Amino­und Nitroderivate und ihre Fo1gen fUr den Organismus 8, 195 (1965) Stoffwechse1 von Arzneimitteln a1s Ursache von Wirkungen, Nebenwir­kungen und Toxizitiit 15,147 (1971)

Mode of death in tetanus 19,439 (1975)

Comparative evaluation of amoebicidal drugs 18, 353 (1974) Comparative efficacy of newer anthelmintics 19, 166 (1975)

Cephalic tetanus 19,443 (1975)

Methods of monitoring adverse reactions to drugs 21,231 (1977) Aspects of social pharmacology 22, 9 (1978)

Index Vol. 1-23

Dr. F. Trende1enburg Leitender Arzt der Robert-Koch-Abtei1ung der Medizinischen Universitiitskliniken, Homburg, Saar, Deutschland

Prof. Dr. P.M. Udani Dr. M. M. Kumbhat Dr. U.S. Bhat Dr. M.S. Nadkarni Dr. S.K. Bhave Dr. S.G. Ezuthachan Dr. B. Kamath The Institute of Child Health, 1.1. Group of Hospita1s~ and Grant Medical College, Bombay 8, India

Prof. Dr. H. Ueh1eke Pharmakologisches Institut der Universitiit Tiibingen, 74 Tiibingen, Deutschland

Prof. Dr. H. Vaishnava Dr. C. Bhawal Dr. Y.P. Munjal Department of Medicine, Mau1ana Azad Medical College and Associated Irwin and G.B. Pant Hospitals, New Delhi, India

Prof. Dr. B.l. Vakil Dr. N.l. Dalal Department of Gastroenterology, Grant Medical College and 1.1. Group of Hospitals, Bombay, India

Prof. Dr. B.l. Vakil Prof. Dr. B. S. Singhal Dr. S. S. Pandya Dr. P.F. Irani 1.1. Group of Hospitals and Grant Medical College, Bombay, India

Prof. Dr. 1. Venulet Division of Clinical Pharmacology, Department of Medicine, Hopital Cantonal and University of Geneva, Geneva, Switzerland. Formerly: Senior Project Officer, WHO Research Centre for International Monitoring of Adverse Reactions to Drugs, Geneva, Switzerland

Index Vol. 1-23

The current status of cholera toxoid research in the United States 19,602 (1975)

Cell-kinetic and pharmacokinetic aspects in the use and further development of cancerostatic drugs 20,521 (1976)

The problem of diphteria as seen in Bombay 19,452 (1975)

Cell-wall antigens of V. cholerae and their implication in cholera immunity 19,612 (1975)

Where is immunology taking us? 20,573 (1976)

A pharmacological approach to allergy 3,409 (1961)

A new approach to the medical interpretation of shock 14, 196 (1970)

Adverse reactions of sugar polymers in animals and man 23, 27 (1979)

Dr. W.F. Verwey Dr. J. C. Guckian Dr. J. Craig Dr. N. Pierce Dr. J. Peterson Dr. H. Williams, Jr.

319

The University of Texas Medical Branch, Galveston, State University of New York Medical Center (Downstate), and Johns Hopkins University School of Medicine, USA

Prof. Dr. M. von Ardenne Forschungsinstitut Manfred von Ardenne, Dresden, GDR

Prof. Dr. M.M. Wagle Dr. R. R. Sanzgiri Dr. Y.K. Amdekar Institute of Child Health, J.J. Group of Hospitals and Grant Medical College, Bombay 8, India

Dr. Y. Watanabe Dr. R. Ganguly Bacterial Diseases, Division of Communicable Diseases, World Health Organization, Geneva 27, Switzerland

Dr. W.J. Wechter Dr. Barbara E. Loughman Hypersensitivity Diseases Research, The Upjohn Company, Kalamazoo, Michigan, USA

Dr. G.B. West Reader in the School of Phannacy, Department of Pharmacology, University of London, London, England

Dr. G.B. West Scientific Secretary, The British Industrial Biological Research Association, Woodmansteme Road, Carshalton, Surrey, England Dr. M. S. Starr Department of Pharmacology, St. Mary's Hospital Medical School, University of London, London, England

Dr. G.B. West Department of Paramedical Sciences, North­East London Polytechnic, London, England

320

Some biochemical and pharmacological properties of anti­inflammatory drugs 8,321 (1965)

Wirksamkeit und Nebenwirkungen von Metronidazol in der Therapie der Trichomonasis 9,361 (1966)

Nonsteroid antiinflammatory agents 10, 139 (1966)

Basic research in the US pharmaceutical industry 15,204 (1971)

The chemotherapy of amoebiasis 8, 11 (1965)

Antimetabolites and their revolution in pharmacology 2,613 (1960)

Krebswirksame Antibiotika aus Actinom yceten 3,451 (1961)

Lysostaphin: model for a specific enzymatic approach to infectious disease 16, 309 (1972)

Index Vol. 1-23

Dr. M. W. Whitehouse Lecturer in Biochemistry at the University of Oxford, Oxford, England

Dr. K. Wiesner Tierarzt, wissenschaftlicher Mitarbeiter der Pharmawissenschaftlichen Literaturabteilung, Farbenfabriken Bayer AG, Leverkusen, Deutschland Dr. H. Fink Leiter der Pharmawissenschaftlichen Literaturabteilung, Farbenfabriken Bayer AG, Leverkusen, Deutschland

Dr. C.A. Winter Senior Investigator Pharmacology, Merck Institute for Therapeutic Research, West Point, Pennsylvania, USA

Dr. O. Wintersteiner The Squibb Institute for Medical Research, New Brunswick, New Jersey, USA

Dr. G. Woolfe Head of the Chemotherapy Group of the Research Department at Boots Pure Drug Company Ltd., Nottingham, England

Dr. D. W. Woolley The Rockefeller Institute, New York, USA

Dr. Kh. Zepf Forschungschemiker im biochemischen und mikrobiologischen Laboratorium der Farbwerke Hoechst, Frankfurt a.M., Deutschland Dr. Christa Zepf Referentin f"Ur das Chemische Zentralblatt, Kelkheim (Taunus), Deutschland

Dr. W.A. Zygmunt Department of Biochemistry, Mead Johnson Research Center, Evansville, Indiana, USA Dr. P.A. Tavormina Director of Biochemistry, Mead Johnson Research Center, Evansville, Indiana, USA