3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Stress – eine Definitionnach S. Levine (2005)
Stress ist ein multidimensionales Konstrukt, in dem drei (Haupt)Komponenten interagieren:
(1) Wahrnehmung der Belastung (Input, Stressor)(2) Verarbeitung der stressreichen Information(3) Die Stress-Reaktion (Output)
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Stress – eine Definitionnach S. Levine (2005)
Stress ist ein multidimensionales Konstrukt, in dem drei (Haupt)Komponenten interagieren:
(1) Wahrnehmung der Belastung (Input, Stressor)
Ist der Stressor/die Situation bedrohlich für Leib oder Seele?
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Stress – eine Definitionnach S. Levine (2005)
Stress ist ein multidimensionales Konstrukt, in dem drei (Haupt)Komponenten interagieren:
(1) Wahrnehmung der Belastung (Input, Stressor)(2) Verarbeitung der stressreichen Information(3) Die Stress-Reaktion (Output)
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Stress !!
Organe
Hormone
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Stress – eine Definitionnach S. Levine (2005)
Verarbeitung der stressreichen Information
Ist der Stressor/die Situation
(a) kontrollierbar?(b) mehrdeutig?(c) vorhersagbar?
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Chrousos, 2009
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Time (hrs)
9 11 13 15 17 19
Cor
tisol
(nm
ol/l)
0
2
4
6
8
10
12
14
16
Control Day
Cortisol Responses in Novice Parachute Jumpers 3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Day Time (hrs)9 11 13 15 17 19
Cor
tisol
(nm
ol/l)
0
10
20
30
40
50
60
Control Day
Day Time (hrs)9 11 13 15 17 19
Cor
tisol
(nm
ol/l)
0
10
20
30
40
50
60'Jump Day'Control Day
Jump #2
Jump #1
Jump #3
Cortisol Responses in Novice Parachute Jumpers 3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
-20 0 20 40 60 80 100
Sal
ivar
y C
ortis
ol (n
mol
/l)
5
10
15
20
25
30
35
-20 0 20 40 60 80 1005
10
15
20
25
30
35
-20 0 20 40 60 80 1005
10
15
20
25
30
35TSST 1 TSST 2 TSST 3
Neuroticism Extraversion Self Esteem
Prüssner et al., Psychosom Med, 1995; Schommer et al., Psychosom Med, 2003
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
There is stress on the dance floor…3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
There is stress on the dance floor…
0
5
10
15
20
25
30
35
40
45
50-6
hrs
-4 h
rs
-2 h
rs
Peak
+2 h
rs
+4 h
rs
+6 h
rs
Corti
sol (
nmol/
l)
0
10
20
30
40
50
60
Control Tournament 1 Tournament 2 Tournament 3C
ortis
ol (
nmol
/l)
C
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Stress (e.g., psychosocial stress)
GC
GC GR
GC GR
How stress turns on inflammation
Proinflammatory Cytokines
IκBα IκBα IκBα NF-κB
NF-κB Translocation
NF-κB
IκBα
Proteolysis
DNA
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
0
1
2
3
4
8
1 min 10 min 60 min
x-fo
ld in
duct
ion
of N
F- κ B
bin
ding
act
ivity
p = 0.0089 p = 0.073
n = 19
p = 0.0705
Bierhaus et al., Proc Natl Acad Sci, 2003
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Chrousos, 2009 Nature Reviews Endocrinology
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Searching for the HbA1c – like Stress Index 3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Cortisol in Hair A Retrospective Measure of Cumulative Cortisol Exposure
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Cortisol in Hair A Retrospective Measure of Cumulative Cortisol Exposure
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Cortisol in Hair A Retrospective Measure of Cumulative Cortisol Exposure
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Cortisol in Hair A Retrospective Measure of Cumulative Cortisol Exposure
Trait of State?
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Hair cortisol t1(pg/mg, log transformed)
0,8 1,0 1,2 1,4 1,6 1,8 2,0
Hai
r cor
tisol
t3(p
g/m
g, lo
g tra
nsfo
rmed
)
0,6
0,8
1,0
1,2
1,4
1,6
1,8
2,0
d) Study II, t1 - t3:
r = .68, p < .0001
Hair cortisol t2(pg/mg, log transformed)
0,8 1,0 1,2 1,4 1,6 1,8 2,0
Hai
r cor
tisol
t3(p
g/m
g, lo
g tra
nsfo
rmed
)
0,6
0,8
1,0
1,2
1,4
1,6
1,8
2,0
r = .74, p < .0001
c) Study II, t2 - t3:
Hair cortisol 2009 (pg/mg; log transformed)
0,6 0,8 1,0 1,2 1,4 1,6 1,8
Hai
r co
rtis
ol 2
010
(pg/
mg;
log
trans
form
ed)
0,8
1,0
1,2
1,4
1,6
1,8
2,0
r = .73, p < .0001
a) Study I:
Hair cortisol t1(pg/mg, log transformed)
0,8 1,0 1,2 1,4 1,6 1,8 2,0
Hai
r co
rtis
ol t2
(pg/
mg,
log
trans
form
ed)
0,8
1,0
1,2
1,4
1,6
1,8
2,0
r = .79, p < .0001
b) Study II, t1 - t2:
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
n =
79
n =
71
n =
84
light - middle blond
dark blond - light brown
middle - dark brown
Hai
r cor
tisol
(pg/
mg)
0
5
10
15
20
25
n =
79
n =
71
n =
84
n =
79
n =
71
n =
84
light - middle blond
dark blond - light brown
middle - dark brown
Hai
r cor
tisol
(pg/
mg)
0
5
10
15
20
n =
79
n =
71
n =
84
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Hair washes per week
0 - 1 1,5 - 2 2,5 - 3 3,5 - 4 4,5 - 5 5,5 - 6 6,5 - 9
Hai
r cor
tisol
(pg/
mg)
0
5
10
15
20
25
n =
17
n =
25
n =
97
n =
48
n =
16
n =
13
n =
33
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Cortisol in Hair The Individual´s History Book of Steroid Production?
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Cortisol in Hair The Individual´s History Book of Steroid Production
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Cortisol in Hair The Individual´s History Book of Steroid Production
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Chrousos, Nature Reviews Endocrinology, 2009
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3cm
3cm
3cm
hair growth rate approx. 1cm / month
-4 to -6 months Past 3 months
Hair Cortisol and Acute Myocardial Infarct Looking Back in the Individual´s History Book of Steroid Production
-7 to -9 months
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Chrousos, 2009
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Ear
ly m
orni
ng
fast
ing
bloo
d HDL LDL triglycerides HbA1c
WHR BMI Mean arterial blood pressure
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Ear
ly m
orni
ng
fast
ing
bloo
d HDL LDL triglycerides HbA1c
WHR BMI Mean arterial blood pressure
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
Hair cortisone(pg/mg; log10 transf.)
0,6 0,8 1,0 1,2 1,4 1,6 1,8 2,0 2,2
Car
diom
etab
olic
risk
(a
rbitr
ary
units
)
0,85
0,90
0,95
1,00
1,05
1,10
1,15
1,20
Hair cortisone - Quintiles
1 2 3 4 5
Car
diom
etab
olic
risk
(a
rbitr
ary
units
)
0,97
0,98
0,99
1,00
1,01
1,02
1,03
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
3cm
3cm
3cm
hair growth rate approx. 1cm / month
-4 to -6 months Past 3 months
Hair Cortisol and Stroke novel options...
-7 to -9 months
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum
http://biopsychologie.tu-dresden.de
3. Prophylaxe-Seminar des KNS
© Clemens Kirschbaum